Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo
Cedó Giné, Lídia
Fernández Castillejo, Sara
Tondo i Colomer, Mireia
Méndez Lara, Karen Alejandra
Blanco Vaca, Francisco
Escolà Gil, Joan Carles
MetadataShow full item record
The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol transport (RevCT) from macrophages to feces in vivo. Female C57BL/6 mice were given intragastric doses of refined OO (ROO) and a functional unrefined virgin OO enriched with its own PC (FVOO) for 14 days. Our experiments included two independent groups of mice that received intragastric doses of the phenolic extract (PE) used to prepare the FVOO and the vehicle solution (saline), as control, for 14 days. FVOO intake led to a significant increase in serum HDL cholesterol and its ability to induce macrophage cholesterol efflux in vitro when compared with ROO group. This was concomitant with the enhanced macrophage-derived [3H]cholesterol transport to feces in vivo. PE intake per se also increased HDL cholesterol levels and significantly promoted in vivo macrophage-to-feces RevCT rate when compared with saline group. PE upregulated the expression of the main macrophage transporter involved in macrophage cholesterol efflux, the ATP binding cassettea1. Our data provide direct evidence of the crucial role of OO PCs in the induction of macrophage-specific RevCT in vivo.
Is part ofBiomedicines, 2020, vol. 8, núm. 8, article 266
European research projects
Except where otherwise noted, this item's license is described as cc-by, (c) Cedó Giné, Lídia et al., 2020
Showing items related by title, author, creator and subject.
A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial Farràs, Marta; Arranz, Sara; Carrión Bolorino, Silvia; Subirana Cachinero, Isaac; Muñoz-Aguayo, Daniel; Blanchart, Gemma; Kool, Marjon; Solà, Rosa; Motilva Casado, Mª José; Escolà Gil, Joan Carles; Rubió Piqué, Laura; Fernández Castillejo, Sara; Pedret, Anna; Estruch Riba, Ramon; Covas Planells, María Isabel; Fitó, Montserrat; Hernáez Camba, Álvaro; Castañer, Olga (MDPI, 2019)The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) ...
Impact of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on the HDL Proteome in Hypercholesterolemic Subjects: A Double Blind, Randomized, Controlled, Cross-Over Clinical Trial (VOHF Study) Pedret, Anna; Catalán Santos, Úrsula; Fernandez-Castillejo, Sara; Farràs, Marta; Valls, Rosa M.; Rubió Piqué, Laura; Canela, Núria; Aragonés, Gerard; Romeu, Marta; Castaner, Olga; De la Torre, Rafael; Covas Planells, María Isabel; Fitó, Montserrat; Motilva Casado, Mª José; Solà, Rosa (Public Library Science, 2015-06-10)The effects of olive oil phenolic compounds (PCs) on HDL proteome, with respect to new aspects of cardioprotective properties, are still unknown. The aim of this study was to assess the impact on the HDL protein cargo of ...
Impact of Phenol‐Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease Daimiel, Lidia; Micó, Víctor; Valls, Rosa M.; Pedret, Anna; Motilva Casado, Mª José; Rubió Piqué, Laura; Fitó, Montserrat; Farràs, Marta; Covas Planells, María Isabel; Solà, Rosa; Ordovás, José M. (WILEY‐VCH Verlag, 2020-06-20)Scope: We investigate the postprandial modulation of cardiovascular‐related microRNAs elicited by extra virgin olive oil (EVOOs) containing different levels of their own polyphenols. Methods and results: It is randomized, ...