Redox lipidomics to better understand brain aging and function

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2019
Author
Pamplona Gras, Reinald
Borràs, Consuelo
Jové Font, Mariona
Pradas Barriga, Irene
Ferrer, Isidre
Viña Ribes, José
Suggested citation
Pamplona Gras, Reinald; Borràs, Consuelo; Jové Font, Mariona; Pradas Barriga, Irene; Ferrer, Isidre; Viña Ribes, José; . (2019) . Redox lipidomics to better understand brain aging and function. Free Radical Biology and Medicine, 2019, vol. 144, núm. 1, p. 310-321. https://doi.org/10.1016/j.freeradbiomed.2019.03.016.
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Abstract
Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging. Yet the molecular mechanisms that sustain the preservation or deterioration of neurons and PFC functions are unknown. In this review, we focus on the role of lipids in human PFC aging. As the evolution of brain lipid concentrations is particularly accelerated in the human PFC, conferring a specific lipid profile, a brief approach to the lipidome of PFC was consider along with the relationship between lipids and lipoxidative damage, and the role of lipids in human PFC aging. In addition, the specific targets of lipoxidative damage in human PFC, the affected biological processes, and their potential role in the cognitive decline associated with aging are discussed. Finally, interventions designed to modify this process are considered. We propose that the dysfunction of key biological processes due to selective protein lipoxidation damage may have a role the cognitive decline of PFC during aging.
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http://hdl.handle.net/10459.1/67893
DOI
https://doi.org/10.1016/j.freeradbiomed.2019.03.016
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Free Radical Biology and Medicine, 2019, vol. 144, núm. 1, p. 310-321
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