Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women

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2019-11-05
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Pradas Barriga, Irene
Rovira-Llopis, Susana
Naudí i Farré, Alba
Bañuls, Celia
Rocha, Milagros
Hernandez-Mijares, Antonio
Pamplona Gras, Reinald
Victor, Victor M.
Jové Font, Mariona
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Pradas Barriga, Irene; Rovira-Llopis, Susana; Naudí i Farré, Alba; Bañuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; ... Jové Font, Mariona. (2019) . Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women. Scientific Reports, 2019, vol. 9, núm. 1: 16033, p. 1-11. https://doi.org/10.1038/s41598-019-52263-w.
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Abstract
Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial process in pcoS pathology. We have employed a lipidomic approach to explore alterations in the plasma lipid profile of patients with PCOS following metformin treatment. The aim is to offer new insights about the effect of metformin in PCOS patients. Plasma samples were obtained from 27 subjects prior to and following 12 weeks of metformin treatment. A detailed biochemical characterization and lipidomic profile was performed. Metformin reduces BMI, HOMA-IR, fSH and androstenedione and increases DHeA-S but no changes were found in glucose levels after treatment. Multivariate statistics revealed a specific lipidomic signature due to the effect of 12 weeks of metformin treatment in pcoS patients. this signature includes changes in sphingolipid metabolism suggesting a crosstalk between these lipid species and the androgenic metabolism and a decrease in oxidized lipids reinforcing that metformin treatment improves oxidative stress status. our study confirms the specific effect of metformin in lipid metabolism on women with PCOS after 12 weeks of treatment.
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http://hdl.handle.net/10459.1/67880
DOI
https://doi.org/10.1038/s41598-019-52263-w
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Scientific Reports, 2019, vol. 9, núm. 1: 16033, p. 1-11
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cc-by (c) Pradas Barriga, Irene et al., 2019
Except where otherwise noted, this item's license is described as cc-by (c) Pradas Barriga, Irene et al., 2019