L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

Recent Submissions

  • Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer 

    Gatius Calderó, Sònia; Jové Font, Mariona; Megino-Luque, Cristina; Albertí Valls, Manel; Yeramian Hakim, Andree; Bonifaci, Núria; Piñol, Miquel; Santacana Espasa, Maria; Pradas Barriga, Irene; Llobet Navàs, David; Pamplona Gras, Reinald; Matías-Guiu, Xavier; Eritja Sánchez, Núria (MDPI, 2022)
    Metabolomic profiling analysis has the potential to highlight new molecules and cellular pathways that may serve as potential therapeutic targets for disease treatment. In this study, we used an LC-MS/MS platform to define, ...
  • Enhancing Night and Day Circadian Contrast through Sleep Education in Prediabetes and Type 2 Diabetes Mellitus: A Randomized Controlled Trial 

    García Serrano, Cristina; Pujol Salud, Jesús; Aran Solé, Lidia; Sol, Joaquim; Ortiz Congost, Sònia; Artigues i Barberà, Eva María; Ortega Bravo, Marta (MDPI, 2022)
    Background: Evidence supports a causal relationship between circadian disturbance and impaired glucose homeostasis. Methods: To determine the effect of an educational intervention delivered by primary care nurses to ...
  • Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice 

    Bellí i Martínez, Gemma; Colomina i Gabarrella, Neus; Castells i Roca, Laia; Pérez Lorite, Neus (MDPI, 2022)
    The sliding clamp PCNA is a multifunctional homotrimer mainly linked to DNA replication. During this process, cells must ensure an accurate and complete genome replication when constantly challenged by the presence of DNA ...
  • Psychometric properties of the Spanish version of the Psychopathy Checklist: Youth Version 

    Ivanova Serokhvostova, Anastasiya; Molinuevo, Beatriz; González, Leonor; Hilterman, Ed; Pardo, Yolanda; Pera Guardiola, Vanessa; Bonillo, Albert; Batalla, Iolanda; Torrubia, Rafael; Forth, Adelle (Springer Nature, 2022)
    The current study examined the psychometric properties (factor structure, reliability and validity) of the Psychopathy Checklist: Youth Version (PCL:YV; Forth et al., 2003) in Spanish samples of male justice-involved youths ...
  • Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function 

    Mayneris Perxachs, Jordi; Arnoriaga Rodríguez, María; Garre Olmo, Josep; Puig, Josep; Ramos, Rafael; Trelis, Maria; Burokas, Aurelijus; Coll, Clàudia; Zapata, Cristina; Pedraza, Salvador; Pérez Brocal, Vicente; Ramió Torrentà, Lluís; Ricart, Wifredo; Moya, Andrés; Jové Font, Mariona; Sol, Joaquim; Portero Otín, Manuel; Pamplona Gras, Reinald; Maldonado, Rafael; Fernández Real, José Manuel (Springer Nature, 2022)
    Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly ...
  • Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial 

    José, Viña; Escudero, Joaquín; Baquero, Miquel; Cebrián, Mónica; Carbonell Asíns, Juan Antonio; Muñoz, José Enrique; Satorres, Encarnación; Meléndez, Juan Carlos; Ferrer Rebolleda, José; Cózar Santiago, Mª Del Puig; Santabárbara Gómez, Jose Manuel; Jové Font, Mariona; Pamplona Gras, Reinald; Tarazona Santabalbina, Francisco José; Borrás, Consuelo (BMC, 2022)
    Background: Delaying the transition from minimal cognitive impairment to Alzheimer’s dementia is a major concern in Alzheimer’s disease (AD) therapeutics. Pathological signs of AD occur years before the onset of clinical ...
  • Evolution of an Iron-Detoxifying Protein: Eukaryotic and Rickettsia Frataxins Contain a Conserved Site Which Is Not Present in Their Bacterial Homologues 

    Alves, Rui; Pazos Gil, Maria; Medina Carbonero, Marta; Sanz Alcázar, Arabela; Delaspre, Fabien; Tamarit Sumalla, Jordi (MDPI, 2022)
    Friedreich’s ataxia is a neurodegenerative disease caused by mutations in the frataxin gene. Frataxin homologues, including bacterial CyaY proteins, can be found in most species and play a fundamental role in mitochondrial ...
  • Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy 

    Julve, Josep; Rossell, Joana; Correig, Eudald; Rojo López, Marina Idalia; Amigó, Núria; Hernández García, Marta; Traveset Maeso, Alicia; Carbonell, Marc; Alonso, Núria; Mauricio Puente, Dídac; Castelblanco Echavarría, Esmeralda (MDPI, 2022)
    This study aimed to assess whether the advanced characteristics of serum lipoprotein subclasses could better predict the risk of developing diabetic retinopathy (DR) and its severity compared to other established risk ...
  • Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus 

    Castelblanco Echavarría, Esmeralda; Hernández García, Marta; Alonso, Núria; Ribes Betriu, Aina; Real, Jordi; Granado Casas, Minerva; Rossell, Joana; Rojo López, Marina Idalia; Dusso Rosso, Adriana; Julve, Josep; Mauricio Puente, Dídac (BMC, 2022)
    Background Compelling evidence suggests that the fbroblast growth factor 23 (FGF23) / α-klotho axis is impaired in subjects with diabetes mellitus. We examined the relationship between parameters related to calcium/phosphate ...
  • A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers 

    Torres Cabestany, Pascual; Anerillas Aljama, Carlos; Ramírez Núñez, Omar; Encinas Martín, Mario; Povedano, Mònica; Andrés-Benito, Pol; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald; Portero Otín, Manuel (The Company of Biologists, 2022)
    To evaluate senescence mechanisms, including senescence associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase ...
  • Factor structure of the Maslach Burnout Inventory Human Services Survey in Spanish urgency healthcare personnel: a cross-sectional study 

    Forné Izquierdo, Carles; Yuguero Torres, Oriol (Springer Nature, 2022)
    Background: The Maslach Burnout Inventory (MBI) is an instrument commonly used to evaluate burnout syndrome. The goal of the present study was to assess the internal reliability and the performance of the items and the ...
  • Peripheral venous catheter-related phlebitis: A meta-analysis of topical treatment 

    García Expósito, Judith; Sánchez Meca, Julio; Almenta Saavedra, José Alberto; Llubes Arrià, Laia; Torné Ruiz, Alba; Roca Llobet, Judith (Wiley, 2022-10-12)
    Aim To systematically evaluate the efficacy of different topical treatments for PVC-related phlebitis in hospital in-patients. Design A systematic review and meta-analysis. Methods A selection was made of experimental and ...
  • High-Intensity Interval Training (HIIT) on Biological and Body Composition Variables in Patients with Musculoskeletal Disorders: A Systematic Review and Meta-Analysis 

    Casaña, Jose; Varangot-Reille, Clovis; Calatayud, Joaquin; Suso-Martí, Luis; Sanchís-Sánchez, Enrique; Aiguadé Aiguadé, Ramon; López-Bueno, Rubén; Gargallo, Pedro; Cuenca-Martínez, Ferran; María Blanco-Díaz (MDPI, 2022-11-24)
    In order to assess the impact of high-intensity interval training (HIIT) on biological and body composition variables in patients with musculoskeletal disorders (MSKD), a systematic search on PubMed (Medline), CENTRAL, ...
  • Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea 

    Marin-Oto, Marta; Sanz Rubio, David; Santamaría Martos, Fernando; Benítez, Iván; Simon, Ana L.; Forner, Marta; Cubero, Pablo; Gil, Ana; Sanchez de la Torre, Manuel; Barbé Illa, Ferran; Marin, José M. (BMC, 2022)
    Background: Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-infammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, ...
  • Percepción de la atención sanitaria en la primera experiencia de maternidad y paternidad 

    Loezar Hernández, Mariana; Briones Vozmediano, Erica Tula; Gea Sánchez, Montserrat; Otero García, Laura (Elsevier, 2022)
    Objetivo: Conocer las percepciones de madres y padres primerizas/os sobre la atención sanitaria recibidadurante la transición hacia la maternidad y la paternidad.Método: Estudio cualitativo basado en 12 entrevistas ...
  • Proteomic profiling of lung diffusion impairment in therecovery stage of SARS-CoV-2–induced ARDS 

    García Hidalgo, María Coronada; González, Jessica; Benítez, Iván; Carmona, Paola; Santisteve, Sally; Moncusí Moix, Anna; Gort Paniello, Clara; Rodríguez Jara, Fátima; Molinero, Marta; Perez-Pons, Manel; Torres, Gerard; Caballero, Jesús; Barberà, Carme; Tedim, Ana P.; Almansa, Raquel; Ceccato, Adrián; Fernández Barat, Laia; Ferrer, Ricard; Garcia-Gasulla, Dario; Menéndez, Rosario; Motos, Anna; Peñuelas, Oscar; Riera, Jordi; Bermejo Martin, Jesús F.; Torres, Antoni; Barbé Illa, Ferran; de Gonzalo Calvo, David (John Wiley & Sons, Ltd, 2022)
  • Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS 

    García Hidalgo, María Coronada; González, Jessica; Benítez, Iván; Carmona, Paola; Santisteve, Sally; Perez-Pons, Manel; Moncusí Moix, Anna; Gort Paniello, Clara; Rodríguez Jara, Fátima; Molinero, Marta; Belmonte, Thalía; Torres, Gerard; Labarca, Gonzalo; Nova Lamperti, Estefania; Caballero, Jesús; Bermejo Martin, Jesús F.; Ceccato, Adrián; Fernández Barat, Laia; Ferrer, Ricard; Garcia-Gasulla, Dario; Menéndez, Rosario; Motos, Anna; Peñuelas, Oscar; Riera, Jordi; Torres, Antoni; Barbé Illa, Ferran; de Gonzalo Calvo, David (Taylor and Francis Group, 2022)
    There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function ...
  • Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view 

    Craig, Sonya; Pepin, Jean Louis; Randerath, Winfried; Caussé, Christian; Verbraecken, Johan; Asin, Jerryll; Barbé Illa, Ferran; Bonsignore, Maria R. (European Respiratory Society, 2022)
    Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA), defined as the inability to stay awake during the day. Its clinical descriptors remain elusive, and the pathogenesis is complex, ...
  • Molecular Mechanisms of Kidney Injury and Repair 

    Rayego Mateos, Sandra; Marquez Exposito, Laura; Rodrigues Díez, Raquel; Sanz, Ana B.; Guiteras, Roser; Dolade, Nuria; Rubio Soto, Irene; Manonelles Montero, Anna; Codina, Sergi; Ortiz, Alberto; Cruzado, Josep M.; Ruiz-Ortega, Marta; Sola, Anna (MDPI, 2022)
    Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus emphasizing the need to better understand the molecular mechanisms of damage and regeneration in the kidney. CKD predisposes to acute ...
  • Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection 

    Molinero, Marta; Gómez Falguera, Silvia; Benítez, Iván; Vengoechea Aragoncillo, José Javier; González, Jessica; Polanco, Dinora; Gort Paniello, Clara; Moncusí Moix, Anna; García Hidalgo, María Coronada; Perez-Pons, Manel; Belmonte, Thalía; Torres, Gerard; Caballero, Jesús; Barberà, Carme; Ayestarán Rota, Jose Ignacio; Socias, Lorenzo; Ceccato, Adrián; Fernández Barat, Laia; Ferrer, Ricard; Garcia-Gasulla, Dario; Lorente, José Ángel; Menéndez, Rosario; Motos, Anna; Peñuelas, Oscar; Riera, Jordi; Torres, Antoni; Barbé Illa, Ferran; de Gonzalo Calvo, David (Frontiers Media, 2022)
    Introduction: Bronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making. Aim: To identify the proteomic determinants associated ...

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