L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

Recent Submissions

  • Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes 

    Cerdán Santacruz, Carlos; Codina Corrons, Laia; Merichal Resina, Mireia; Milla Collado, Lucía; Trujillano Cabello, Javier; Tarragona Foradada, Jordi; Mestres Petit, Núria; Sierra Grañón, Enrique; Olsina Kissler, Jorge Juan (Shiraz University of Medical Sciences, 2021)
    BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using ...
  • Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective 

    Bauer, Kylynda C.; Littlejohn, Paula T.; Ayala Jové, Ma. Victoria (Maria Victoria); Creus Cuadros, Anna; Finlay, Barton Brett (AGA InstituteElsevier, 2022)
    Nonalcoholic fatty liver disease (NAFLD) is a chronic con dition affecting one quarter of the global population. Although primarily linked to obesity and metabolic syn drome, undernutrition and the altered (dysbiotic) gut ...
  • The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology 

    Jové Font, Mariona; Mota Martorell, Natàlia; Torres Cabestany, Pascual; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (MDPI, 2021)
    Current shreds of evidence point to the entorhinal cortex (EC) as the origin of the Alzheimer’s disease (AD) pathology in the cerebrum. Compared with other cortical areas, the neurons from this brain region possess an ...
  • Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment 

    Rossi, Chiara; Fernàndez, Anna; Torres Cabestany, Pascual; Ramírez Núñez, Omar; Granado-Serrano, Ana Belén; Fontdevila, Laia; Povedano, Mònica; Pamplona Gras, Reinald; Ferrer, Isidre; Portero Otín, Manuel (MDPI, 2021)
    Previous evidence links the formation of extranuclear inclusions of transcription factors, such as ERK, Jun, TDP-43, and REST, with oxidative, endoplasmic-reticulum, proteasomal, and osmotic stress. To further characterize ...
  • Redox proteomic profiling of neuroketal-adducted proteins in human brain: regional vulnerability at middle age increases in the elderly 

    Domínguez, Mayelín; de Oliveira, Eliandre; Odena, María Antonia; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (2016)
    Protein lipoxidation was assessed in the parietal cortex (PC), frontal cortex (FC), and cingulate gyrus (CG) in middle-aged and old-aged individuals with no clinical manifestations of cognitive impairment, in order to ...
  • Molecular and structural antioxidant defenses against oxidative stressin animals 

    Pamplona Gras, Reinald; Costantini, David (American Physiological Society, 2011)
    In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural ...
  • Proteins in human brain cortex are modified by oxidation, glycoxidation and lipoxidation: effects of Alzheimer's disease and identification of lipoxidation targets. 

    Pamplona Gras, Reinald; Dalfó, Esther; Ayala Jové, Ma. Victoria (Maria Victoria); Bellmunt, Maria Josep; Prat Corominas, Joan; Ferrer, Isidre; Portero Otín, Manuel (American Society for Biochemistry and Molecular BiologyElsevier, 2005)
    Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the amount of structurally characterized probes ...
  • Melanoma transplants in “green” mice: Fluorescent cells in tumors are not equivalent to host-derived cells 

    García-Olmo, Dolores C.; Picazo, María G.; García-Olmo, Damián (Elsevier, 2018)
    Background: To examine the usefulness of green fluorescent protein (GFP) mice for studying the interactions between normal cells and tumor cells in a host, we used a melanoma model in such “green” mice [C57BL/6-Tg(CAG-EGFP)1Osb ...
  • Diálisis peritoneal incremental: resultados clínicos y preservación de la función renal residual 

    Borràs, Mercè; Chacón, Andrea; Cerdá Vilaplana, Carla; Usón Nuño, Ana; Fernández i Giráldez, Elvira (Sociedad Española de NefrologíaElsevier, 2016)
    Introducción: En los últimos años el inicio de diálisis peritoneal (DP) con 3 recambios se ha convertido en una práctica habitual, aunque se dispone de pocos resultados clínicos publicados. Objetivo: Descripción de la ...
  • Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals 

    Pamplona Gras, Reinald; Portero Otín, Manuel; Riba, David; Ruiz, Cristina; Prat Corominas, Joan; Bellmunt, Maria Josep; Barja, Gustavo (Elsevier, 1998)
    The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. ...
  • Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness 

    Cambray Carner, Serafí; Ibarz Escuer, Mercedes; Bermúdez López, Marcelino; Marti Antonio, Manuel; Bozić Stanojević, Milica; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (MDPI, 2020)
    Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with ...
  • Study design of Heart failure Events reduction withRemote Monitoring and eHealth Support (HERMeS) 

    Yun, Sergi; Enjuanes, Cristina; Calero, Esther; Hidalgo, Encarnación; Cobo, Marta; Llàcer, Pau; García Pinilla, José Manuel; González Franco, Álvaro; Núñez, Julio; Morales Rull, José Luis; Beltrán, Paola; Delso, Cristina; Freixa Pamias, Román; Moliner, Pedro; Corbella, Xavier; Comín Colet, Josep (Wiley Open Access, 2020)
    Aims. The role of non-invasive telemedicine (TM) combining telemonitoring and teleintervention by videoconference (VC) in patients recently admitted due to heart failure (HF) (‘vulnerable phase’ HF patients) is not well ...
  • Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation 

    Sarlabous Uranga, Leonardo; Aquino Esperanza, Jose; Magrans, Rudys; de Haro, Candelaria; López-Aguilar, Josefina; Subirà, Carles; Batlle, Montserrat; Rué i Monné, Montserrat; Gomà Fernández, Gemma; Ochagavía, Ana; Fernández, Rafael; Blanch, Lluís (Scientific Reports, 2020)
    Patient-ventilator asynchronies can be detected by close monitoring of ventilator screens by clinicians or through automated algorithms. However, detecting complex patient-ventilator interactions (CP-VI), consisting of ...
  • Multidisciplinary virtual management of pulmonary nodules 

    Polanco, Dinora; González, Jessica; Gracia-Lavedan, Esther; Pinilla, Lucía; Plana, R.; Molina, M.; Pardina Solano, Marina Asunción; Barbé Illa, Ferran (ElsevierSociedade Portuguesa de Pneumologia, 2022)
    Introduction and objectives: Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the ...
  • Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients 

    Molinero, Marta; Benítez, Iván; González, Jessica; Gort Paniello, Clara; Moncusí Moix, Anna; Rodríguez Jara, Fátima; García Hidalgo, María C.; Torres, Gerard; Vengoechea Aragoncillo, José Javier; Gómez Falguera, Silvia; Cabo Gambín, Ramón; Caballero, Jesús; Bermejo Martin, Jesús F.; Ceccato, Adrián; Fernández Barat, Laia; Ferrer, Ricard; García Gasulla, Dario; Menéndez, Rosario; Motos, Anna; Peñuelas, Oscar; Riera, Jordi; Torres, Antoni; Barbé Illa, Ferran; de Gonzalo Calvo, David (Frontiers Media, 2022)
    Background: The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile of bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients ...
  • Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing 

    Sánchez Peña, Enric; Sapiña Beltrán, Esther; Gavaldá, Ricard; Barbé Illa, Ferran; Torres, Gerard; Sauret, Ariadna; Dalmases, Mireia; López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Castro-Boqué, Eva; Farràs-Sallés, Cristina; Pamplona Gras, Reinald; Mauricio Puente, Dídac; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2022)
    Type 2 diabetes leads to severe nocturnal hypoxemia, with an increase in apnea events and daytime sleepiness. Hence, we assessed sleep breathing parameters in the prediabetes stage. A cross-sectional study conducted on 966 ...
  • ICU-Acquired Pneumonia Is Associated with Poor HealthPost-COVID-19 Syndrome 

    Martín Loeches, Ignacio; Motos, Anna; Menéndez, Rosario; Gabarrús, Albert; González, Jessica; Fernández Barat, Laia; Ceccato, Adrián; Pérez Arnal, Raquel; García Gasulla, Dario; Ferrer, Ricard; Riera, Jordi; Lorente, José Ángel; Peñuelas, Oscar; Bermejo Martin, Jesús F.; de Gonzalo Calvo, David; Rodríguez, Alejandro; Barbé Illa, Ferran; Aguilera, Luciano; Amaya Villar, Rosario; Barberà, Carme; Barberán, José; Blandino Ortiz, Aaron; Bustamante Munguira, Elena; Caballero, Jesús; Carbajales, Cristina; Carbonell, Nieves; Catalán González, Mercedes; Galbán, Cristóbal; Gumucio Sanguino, Víctor D.; de la Torre, Maria del Carmen; Díaz, Emili; Gallego, Elena; García Garmendia, José Luis; Garnacho Montero, José; Gómez, José Manuel; Jorge García, Ruth Noemí; Loza Vázquez, Ana; Marin Corral, Judith; Martínez de la Gándara, Amalia; Martínez Varela, Ignacio; López Messa, Juan; Albaiceta, Guillermo M.; Novo, Mariana Andrea; Peñasco, Yhivian; Ricart, Pilar; Urrelo Cerrón, Luis; Sánchez Miralles, Angel; Sancho Chinesta, Susana; Socias, Lorenzo; Solé Violan, Jordi; Tamayo Lomas, Luis; Vidal, Pablo; Torres, Antoni (MDPI, 2021)
    Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to ...
  • The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer's disease patients 

    Targa, Adriano; Benítez, Iván; Dakterzada, Farida; Fontenele Araujo, John; Minguez Roure, Olga; Zetterberg, Henrik; Blennow, Kaj; Barbé Illa, Ferran; Piñol Ripoll, Gerard (BMC, 2021)
    Background:Alterations in circadian rhythms are present in the presymptomatic stage of Alzheimer’s disease (AD),possibly contributing to its pathogenesis. However, it is unknown whether such alterations are associated ...
  • Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID‑19 

    Bermejo Martin, Jesús F.; González Rivera, Milagros; Almansa, Raquel; Micheloud, Dariela; Tedim, Ana P.; Domínguez Gil, Marta; Resino, Salvador; Martín Fernández, Marta; Murua, Pablo Ryan; Pérez García, Felipe; Tamayo Lomas, Luis; López Izquierdo, Raúl; Bustamante Munguira, Elena; Aldecoa, César; Gómez, José Manuel; Rico Feijoo, Jesús; Orduña, Antonio; Méndez, Raúl; Fernández Natal, Isabel; Megías, Gregoria; González Estecha, Montserrat; Carriedo, Demetrio; Doncel, Cristina; Jorge, Noelia; Ortega, Alicia; Fuente, Amanda de la; Campo, Félix del; Fernández Ratero, José Antonio; Trapiello, Wysali; González Jiménez, Paula; Ruiz, Guadalupe; Kelvin, Alyson A.; Toloue Ostadgavahi, Ali; Oneizat, Ruth; Ruiz, Luz María; Miguéns, Iria; Gargallo, Esther; Muñoz, Ioana; Pelegrin, Sara; Martín, Silvia; García Olivares, Pablo; Cedeño, Jamil Antonio; Ruiz Albi, Tomás; Puertas, Carolina; Berezo, Jose Ángel; Renedo, Gloria; Herrán, Rubén; Bustamante Munguira, Juan; Enríquez, Pedro; Cicuendez, Ramón; Blanco, Jesús; Abadia, Jesica; Gómez Barquero, Julia; Mamolar, Nuria; Blanca López, Natalia; Valdivia, Luis Jorge; Fernández Caso, Belén; Mantecón, María Ángeles; Motos, Anna; Fernandez Barat, Laia; Ferrer, Ricard; Barbé Illa, Ferran; Torres, Antoni; Menéndez, Rosario; Eiros, José María; Kelvin, David J. (BMC, 2020)
    Background. COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host ...
  • Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort 

    Zuil, María; Benítez, Iván; Cabo Gambín, Ramón; Manzano Senra, Carlos; Moncusí Moix, Anna; Gort Paniello, Clara; de Gonzalo Calvo, David; Molinero, Marta; Vengoechea Aragoncillo, José Javier; Comella, Thais; Batlle Garcia, Jordi de; Torres, Gerard; Torres, Antoni; Barbé Illa, Ferran; González, Jessica (Public Library of Science, 2021)
    The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total ...

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