L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

Recent Submissions

  • PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia 

    Rodríguez-Pascau, Laura; Britti, Elena; Calap Quintana, Pablo; Na Dong, Yi; Vergara, Cristina; Delaspre, Fabien; Medina Carbonero, Marta; Tamarit Sumalla, Jordi; Pallardó, Federico V.; Gonzalez Cabo, Pilar; Ros, Joaquim; Lynch, David R.; Martinell, Marc; Pizcueta, Pilar (Elsevier, 2021)
    Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The ...
  • Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity 

    Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Berdún Hernández, Rebeca; Sanchez, Isabel; Naudí i Farré, Alba; Garí Marsol, Eloi; Barja, Gustavo; Pamplona Gras, Reinald (Springer, 2020-08-01)
    Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ...
  • Obesity in Patients with Type 1 Diabetes: Links, Risks and Management Challenges 

    Vilarrasa, Núria; San Jose, Patricia; Rubio, Miguel Ángel; Lecube Torelló, Albert (Dove Medical Press, 2021)
    Obesity affects large numbers of patients with type 1 diabetes (T1D) across their lifetime, with rates ranging between 2.8% and 37.1%. Patients with T1D and obesity are characterized by the presence of insulin resistance, ...
  • Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin 

    Pérez Fusté, Noel; Fernández Hernández, Rita; Cemeli, Tània; Mirantes Barbeito, Cristina; Pedraza González, Neus; Rafel i Borrell, Marta; Torres Rosell, Jordi; Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Garí Marsol, Eloi (Nature Research, 2016-05-16)
    Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1 . Cdk4 expression promotes tumour growth and metastasis. While ...
  • Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma 

    Sanegre, Sabina; Eritja Sánchez, Núria; De Andrea, Carlos; Diaz-Martin, Juan; Diaz-Lagares, Ángel; Jácome, María Amalia; Salguero-Aranda, Carmen; García Ros, David; Davidson, Ben; Lopez, Rafel; Melero, Ignacio; Navarro, Samuel; Ramon y Cajal, Santiago; Alava, Enrique de; Matias-Guiu, Xavier; Noguera, Rosa (Frontiers Media, 2021)
    The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular ...
  • ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status 

    Barés Junqué, Gisel; Beà Tàrrega, Aida; Hernández, Luís; Navaridas Fernández de Bobadilla, Raúl; Felip, Isidre; Megino-Luque, Cristina; Blasco Angulo, Natividad; Nadeu, Ferran; Campo, Elías; Llovera i Tomàs, Marta; Dolcet Roca, Xavier; Sanchis, Daniel (MDPI, 2021)
    EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG ...
  • Implementation of a Hybrid Educational Program between the Model of Personal and Social Responsibility (TPSR) and the Teaching Games for Understanding (TGfU) in Physical Education and Its Effects on Health: An Approach Based on Mixed Methods 

    García, Gregorio; Camerino Foguet, Oleguer; Castañer Balcells, Marta; Manzano Sánchez, David; Jiménez Parra, José Francisco; Valero Valenzuela, Alfonso (MDPI, 2021)
    The present study investigates the effect of an educational program hybridized between the Model of Personal and Social Responsibility (TPSR) and the Teaching Games for Understanding (TGfU) in physical education classes ...
  • Identifying thoracic malignancies through pleural fluid biomarkers: a predictive multivariate model 

    Porcel Pérez, José Manuel; Esquerda, Aureli; Martínez Alonso, Montserrat; Bielsa Martín, Silvia; Salud Salvia, Maria Antonieta (Wolters Kluwer Health, 2016-03-01)
    The diagnosis of malignant pleural effusions may be challenging when cytological examination of aspirated pleural fluid is equivocal or noncontributory. The purpose of this study was to identify protein candidate biomarkers ...
  • Spanish-dementia knowledge assessment scale (DKAS-S): psychometric properties and validation 

    Carnes Vendrell, Anna; Barallat Gimeno, Eva; Galvan, Ana; Lara Gallego, Beatriz; Lladó, Albert; Contador-Muñana, Jose; Vega Rodríguez, Angela; Escobar Bravo, Miguel Ángel; Piñol Ripoll, Gerard (BioMed Central, 2021-05-01)
    Background Alzheimer's disease (AD) is the most frequent cause of cognitive impairment. Community knowledge of the disease has proven to be a very important aspect of the development of interventions and the evaluation of ...
  • Ganancia de peso durante el confinamiento por la COVID-19; encuesta de la Sociedad Española de Obesidad 

    López de la Torre, Martín; Bellido, Diego; Monereo, Susana; Lecube Torelló, Albert; Sánchez Peña, Enric; Tinahones, Francisco José (Sociedad Española de Cirugía de Obesidad y Metabólica y Sociedad Española para el Estudio de la Obesidad, 2020-11-01)
    La obesidad, después de la edad, es el principal factor de mal pronóstico durante la infección por la COVID-19. El confinamiento al que la población española ha sido expuesta durante varias semanas puede ser una causa de ...
  • Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome 

    Muniesa Royo, Ma. Jesús; Benítez, Iván; Ezpeleta, Juan Antonio; Sánchez de la Torre, Manuel; Pazos, Marta; Millà, Elena; Barbé Illa, Ferran (Association for Research in Vision and Ophthalmology, 2021-04-01)
    Purpose: To evaluate the effect of continuous positive airway pressure (CPAP) therapy on 24-hour intraocular pressure (IOP)-related pattern from contact lens sensors (CLS) in obstructive sleep apnea syndrome (OSAS). Methods: ...
  • Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study 

    Purroy Garcia, Francisco; Arqué, G. (Public Library of Science, 2021)
    Background COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging. Objective To describe the rate of TEE ...
  • The Risk of Hospitalization in COVID-19 Patients Can Be Predicted by Lung Ultrasound in Primary Care 

    Martínez Redondo, Javier; Comas Rodríguez, Carles; Pujol Salud, Jesús; Crespo Pons, Montserrat; García-Serrano, Cristina; Ortega Bravo, Marta; Palacín Peruga, Jose María (MDPI, 2021)
  • Burnout and job satisfaction among nurses in three Spanish regions 

    Acea-López, Lorena; Pastor-Bravo, María del Mar; Rubinat, Esther; Bellon, Filip; Blanco Blanco, Joan; Gea Sánchez, Montserrat; Briones Vozmediano, Erica Tula (Wiley, 2021-05-15)
    Aims: To determine the levels of job satisfaction and burnout syndrome and related factors among nurses in three Spanish regions. Background: The nursing profession involves high work stress due to emotional involvement, ...
  • Regulation of membrane unsaturation as antioxidant adaptive mechanism in long-lived animal species 

    Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Phcog.Net, 2011)
    Oxidative stress resulting from biomolecular oxidative damage due to the imbalance between reactive species production and antioxidant response has become an universal constraint of life-history evolution in animals and ...
  • Target of rapamycin activation predicts lifespan in fruit flies 

    Scialò, Filippo; Sriram, Ashwin; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Pamplona Gras, Reinald; Sanz, Alberto (Taylor & Francis, 2015-09)
    Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or ...
  • Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment 

    Andrés Benito, Pol; Gelpí, Ellen; Jové Font, Mariona; Mota Martorell, Natàlia; Obis Monné, Èlia; Portero Otín, Manuel; Povedano, Mònica; Pujol, Aurora; Pamplona Gras, Reinald; Ferrer, Isidro (Wiley, 2020-12)
    Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ...
  • Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways 

    Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Contreras-Rodríguez, Oren; Burokas, Aurelijus; Ortega Sánchez, Juan Antonio; Blasco Solà, Gerard; Coll, Claudia; Biarnés, Carles; Castells Nobau, Anna; Puig, Josep; Garre Olmo, Josep; Ramos, Rafel; Pedraza, Salvador; Brugada, Ramon; Vilanova, Joan Carles; Serena, Joaquín; Barretina Ginesta, Jordi; Gich Fullà, Jordi; Pérez Brocal, Vicente; Moya, Andrés; Fernández Real, Xavier; Ramió Torrentà, Lluís; Pamplona Gras, Reinald; Sol, Joaquim; Jové Font, Mariona; Ricart, Wifredo; Portero Otín, Manuel; Maldonado, Rafael; Fernández Real, José Manuel (BMJ Publishing GroupBritish Society of Gastroenterology, 2021-01)
    Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We ...
  • Psychological Well-Being in Nursing Students: A Multicentric, Cross-Sectional Study 

    Reverté-Villarroya, Sílvia; Ortega, Laura; Raigal Aran, Laia; Sauras Colón, Esther; Ricomà Muntané, Roser; Ballester-Ferrando, D.; Rascón Hernán, C.; Botigué, Teresa; Lavedán, Ana; González Osorio, L.; Osorio Spuler, X.; Burjalés, D. (MDPI, 2021-03-15)
    In addition to complying with strict academic standards, nursing students must acquire relevant knowledge and skills, and learn how to carry themselves in different and often stressful professional settings. These obligations ...
  • Cross-cultural validation and psychometric testing of the supportive supervisory scale in Spanish 

    Alconada Romero, Álvaro; Horta-García, Gemma; Gea Sánchez, Montserrat; Blanco Blanco, Joan; Mateos, José Tomás; Stewart, Steven; Barallat Gimeno, Eva; McGilton, Katherine S. (Wiley, 2021-05-15)
    Background: Supervisory effectiveness in long-term care facilities has been identified a key factor in staff satisfaction and quality of care. Determining its utility in Spanish speaking countries will assist with understanding ...

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