Articles publicats (Grup de Recerca en Estrès Cel·lular i Supervivència en Models Eucariotes)
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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
(Nature, 2017)Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery ... -
Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV
(American Society for Biochemistry and Molecular Biology, 2008)Neurotrophic factors promote motoneuron (MN) survival through increased intracellular calcium (Ca(2+)) and regulation of the phosphatidylinositol (PI) 3-kinase/protein kinase B (PKB) pathway by calmodulin (CaM). Activation ... -
Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress
(American Society for Biochemistry and Molecular Biology, 2010)Mtl1 is a member of the cell wall integrity (CWI) pathway of Saccharomyces cerevisiae, which functions as a cell wall sensor for oxidative stress. Genome-wide transcriptional analysis revealed a cluster of genes that were ... -
Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae Play a Role in Actin Dynamics through Their Trx Domains, Which Contributes to Oxidative Stress Resistance
(American Society for Microbiology, 2010)Grx3 and Grx4 are two monothiol glutaredoxins of Saccharomyces cerevisiae that have previously been characterized as regulators of Aft1 localization and therefore of iron homeostasis. In this study, we present data showing ... -
The MAP Kinase Slt2 Is Involved in Vacuolar Function and Actin Remodeling in Saccharomyces cerevisiae Mutants Affected by Endogenous Oxidative Stress
(American Society for Microbiology, 2013)Oxidative stress causes transient actin cytoskeleton depolarization and also provokes vacuole fragmentation in wild-type cells. Under conditions of oxidative stress induced by hydrogen peroxide, the Slt2 protein is required ... -
Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model
(Elsevier, 2014)Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ... -
Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators
(The Company of Biologists, 2015)Fe-S cluster biogenesis machinery is required for multiple DNA metabolism processes. In this work, we show that, in Saccharomyces cerevisiae, defects at different stages of the mitochondrial Fe-S cluster assembly machinery ... -
The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug
(American Society for Microbiology, 2014)Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of reactive oxygen species (ROS), and although ... -
Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice
(Springer Science, Business Media, 2016-06)Oxidative stress has been described as important to Huntington disease (HD) progression. In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are ... -
The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system
(Scientific Reports, 2016)The yeast Saccharomyces cerevisiae is employed as a model to study the cellular mechanisms of toxicity and defense against selenite, the most frequent environmental selenium form. We show that yeast cells lacking Aft2, a ... -
Reversible glutathionylation of Sir2 by monothiol glutaredoxins Grx3/4 regulates stress resistance
(Elsevier, 2016)The regulatory mechanisms of yeast Sir2, the founding member of the sirtuin family involved in oxidative stress and aging, are unknown. Redox signaling controls many cellular functions, especially under stress situations, ... -
Transcriptomic and proteomic insights of the wine yeast biomass propagation process
(Oxford University Press, 2010)Transcriptome and proteome profiles have been established for the commercial wine yeast strain T73 during an important industrial process: yeast biomass propagation. The data from both analyses reveal that the metabolic ... -
Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism
(Elsevier, 2010)Huntington disease (HD) is an inherited neurodegenerative disorder that initially affects the striatum and progressively the cortex. Oxidative stress in HD has been described as important to disease progression. In ... -
Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage
(Elsevier, 2010)Iron overload is involved in several pathological conditions, including Friedreich ataxia, a disease caused by decreased expression of the mitochondrial protein frataxin. In a previous study, we identified 14 proteins ... -
Proteomic and oxidative stress analysis in human brain samples of Huntington disease
(Elsevier, 2008)Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG repeats in exon 1 of the huntingtin gene, affecting initially the striatum and progressively the cortex. This work reports a proteomic analysis ... -
Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins
(Elsevier, 2008)Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the ... -
Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein
(Oxford University Press, 2014)Friedreich ataxia (FRDA) is a neurodegenerative disease characterized by a decreased expression of the mitochondrial protein frataxin. Major neurological symptoms of the disease are due to degeneration of dorsal root ganglion ... -
Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation
(Elsevier, 2011)Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG trinucleotide repeats, leading to an elongated polyglutamine sequence (polyQ) in the huntingtin protein. Misfolding of mutant polyQ ... -
Analysis of oxidative stress-induced protein carbonylation using fluorescent hydrazides
(Elsevier, 2012)Protein carbonyl detection has been commonly used to analyze the degree of damage to proteins under oxidative stress conditions. Most laboratories rely on derivatization of carbonyl groups with dinitrophenylhydrazine ... -
Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1
(Elsevier, 2013)Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ...