Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs
MetadataShow full item record
Among the large number of attributes that define pork quality, fat content and composition have attracted the attention of breeders in the recent years due to their interaction with human health and technological and sensorial properties of meat. In livestock species, fat accumulates in different depots following a temporal pattern that is also recognized in humans. Intramuscular fat deposition rate and fatty acid composition change with life. Despite indication that it might be possible to select for intramuscular fat without affecting other fat depots, to date only one depot-specific genetic marker (PCK1 c.2456C>A) has been reported. In contrast, identification of polymorphisms related to fat composition has been more successful. For instance, our group has described a variant in the stearoyl-coA desaturase (SCD) gene that improves the desaturation index of fat without affecting overall fatness or growth. Identification of mutations in candidate genes can be a tedious and costly process. Genome-wide association studies can help in narrowing down the number of candidate genes by highlighting those which contribute most to the genetic variation of the trait. Results from our group and others indicate that fat content and composition are highly polygenic and that very few genes explain more than 5% of the variance of the trait. Moreover, as the complexity of the genome emerges, the role of non-coding genes and regulatory elements cannot be disregarded. Prediction of breeding values from genomic data is discussed in comparison with conventional best linear predictors of breeding values. An example based on real data is given, and the implications in phenotype prediction are discussed in detail. The benefits and limitations of using large SNP sets versus a few very informative markers as predictors of genetic merit of breeding candidates are evaluated using field data as an example.
Is part ofInternational Journal o f Molecular Sciences, 2016, vol. 17, núm. 12, p 1-17
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Estany Illa, Joan., et al. 2016
Showing items related by title, author, creator and subject.
Tor i Naudí, Marc; Vilaró, Francisca; Ros Freixedes, Roger; Álvarez Rodríguez, Javier; Bosch Puig, Lluís; Gol, Sofia; Pena i Subirà, Ramona Natacha; Reixach, Josep; Estany Illa, Joan (MDPI, 2021-02-03)Circulating non-esterified fatty acids (NEFA) can reflect the composition of dietary fat or adipose tissues depending on the fasting conditions. Therefore, circulating NEFA may be valuable as biomarkers for meat quality ...
Carcass lean-yield effects on the fatty acid and amino acid composition of Duroc pork and its technological quality after vacuum-aging Álvarez Rodríguez, Javier; Ros Freixedes, Roger; Gol, Sofia; Henriquez Rodriguez, Eliana; Pena i Subirà, Ramona Natacha; Bosch Puig, Lluís; Estany Illa, Joan; Vilaró, Francisca; Tor i Naudí, Marc (CSIRO Publishing, 2018)Eighty purebred Duroc castrated male pigs slaughtered at 210 days of age were used to evaluate the effect of lean yield (European Union carcass grading based on lean content; or R, O and P classes) on the fatty acid and ...
Carotenoid intake and SCD genotype exert complementary effects over fat content and fatty acid composition in Duroc pigs Henriquez Rodriguez, Eliana; Pena i Subirà, Ramona Natacha; Seradj, Ahmad Reza; Fraile Sauce, Lorenzo José; Christou, Paul; Tor i Naudí, Marc; Estany Illa, Joan (American Society of Animal Science, 2017)Nutritional and genetic strategies are needed to enhance intramuscular fat (IMF) and MUFA content without altering carcass leanness. Dietary vitamin A restriction has been suggested to specifically promote IMF, whereas ...