Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9

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2015
Author
Hernández García, Marta
Molló Inesta, Àngels
Marsal Mora, Josep Ramon
Esquerda, Aureli
Capel, Ismael
Puig-Domingo, Manuel
Pozzilli, Paolo
Leiva, Alberto de
Mauricio Puente, Dídac
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Hernández García, Marta; Molló Inesta, Àngels; Marsal Mora, Josep Ramon; Esquerda, Aureli; Capel, Ismael; Puig-Domingo, Manuel; ... Mauricio Puente, Dídac. (2015) . Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9. BMC Endocrine Disorders, 2015, núm. 15, p. 1-6. https://doi.org/10.1186/1472-6823-15-1.
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Abstract
Background: The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 diabetes mellitus. The aim of this study was to compare the results of the C-peptide response to mixed-meal stimulation in LADA patients with different disease durations and subjects with type 2 and adult-onset type 1 diabetes. Methods: Stimulated C-peptide secretion was assessed using the mixed-meal tolerance test in patients with LADA (n = 32), type 1 diabetes mellitus (n = 33) and type 2 diabetes mellitus (n = 30). All patients were 30 to 70 years old at disease onset. The duration of diabetes in all groups ranged from 6 months to 10 years. The recruitment strategy was predefined to include at least 10 subjects in the following 3 disease onset categories for each group: 6 to 18 months, 19 months to 5 years and 5 to 10 years. Results: At all time-points of the mixed-meal tolerance test, patients with LADA had a lower stimulated C-peptide response than the type 2 diabetes group and a higher response than the type 1 diabetes group. The same results were found when the peak or area under the C-peptide curve was measured. When the results were stratified by time since disease onset, a similar pattern of residual insulin secretory capacity was observed. Conclusions: The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus.
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http://hdl.handle.net/10459.1/48693
DOI
https://doi.org/10.1186/1472-6823-15-1
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BMC Endocrine Disorders, 2015, núm. 15, p. 1-6
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cc-by, (c) Hernández García, Marta et al., 2015
Except where otherwise noted, this item's license is described as cc-by, (c) Hernández García, Marta et al., 2015