MultitaskProtDB: a database of multitasking proteins
Perez-Pons, Josep Antoni
MetadataShow full item record
We have compiled MultitaskProtDB, available online at http://wallace.uab.es/multitask, to provide a repository where the many multitasking proteins found in the literature can be stored. Multitasking or moonlighting is the capability of some proteins to execute two or more biological functions. Usually, multitasking proteins are experimentally revealed by serendipity. This ability of proteins to perform multitasking functions helps us to understand one of the ways used by cells to perform many complex functions with a limited number of genes. Even so, the study of this phenomenon is complex because, among other things, there is no database of moonlighting proteins. The existence of such a tool facilitates the collection and dissemination of these important data. This work reports the database, MultitaskProtDB, which is designed as a friendly user web page containing >288 multitasking proteins with their NCBI and UniProt accession numbers, canonical and additional biological functions, monomeric/oligomeric states, PDB codes when available and bibliographic references. This database also serves to gain insight into some characteristics of multitasking proteins such as frequencies of the different pairs of functions, phylogenetic conservation and so forth.
Is part ofNucleic Acids Research, 2014, vol. 42, p. 517-520
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Franco-Serrano, Luis; Huerta, Mario; Hernández, Sergio; Cedano, Juan; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Amela, Isaac; Querol, Enrique (Springer Verlag, 2018)Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases ...
Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients Almendros, Isaac; Martínez-García, Miguel Angel; Campos-Rodríguez, Francisco; Riveiro-Falkenbach, Erica; Rodríguez-Peralto, José L.; Nagore, Eduardo; Martorell-Calatayud, Antonio; Hernández Blasco, Luis; Bañuls Roca, Jose; Chiner, Eusebi; Sánchez de la Torre, Alicia; Abad-Capa, Jorge; Montserrat, Josep Maria; Pérez-Gil, Amalia; Cabriada, Valentín; Cano-Pumarega, Irene; Corral-Peñafiel, Jaime; Diaz-Cambriles, Trinidad; Mediano, Olga; Dalmau-Arias, Joan; Farré, Ramon; Gozal, David; Spanish Sleep Network (Frontiers Media, 2018)Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced ...
Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique (Public Library of Science, 2014)The propensity of many proteins to oligomerize and associate to form complex structures from their constituent monomers, is analyzed in terms of their hydrophobic (H), and electric pseudo-dipole (D) moment vectors. In ...