Institut de Recerca Biomèdica de Lleida (IRBLleida)
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L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].
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Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA
(Nature Research, 2018)Spinal muscular atrophy (SMA) is a severe motor neuron (MN) disease caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene, which results in reduced levels of the SMN protein and the selective ... -
¿Cómo mejorar la hidratación y la ingesta hídrica en las personas mayores institucionalizadas? Una revisión de la literatura científica
(Aula Médica Ediciones, 2018)Introducción: los residentes son vulnerables a sufrir deshidratación por los cambios fisiológicos y las limitaciones físicas y cognitivas que padecen. Objetivo: para manejar esta situación, se ha decidido evaluar las ... -
Prevalencia y características de la enfermedad pulmonar obstructiva crónica en no fumadores
(Elsevier, 2018)Objetivo Conocer el perfil y las características de los enfermos diagnosticados de enfermedad pulmonar obstructiva crónica (EPOC) y que nunca han sido fumadores. Diseño Estudio descriptivo transversal. Emplazamiento Área ... -
Treatment strategies after acute exacerbations of chronic obstructive pulmonary disease: Impact on mortality
(Public Library of Science, 2018)Introduction Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common reason for presentation to emergency departments (ED), but the management of these episodes is often heterogeneous regardless ... -
Quality of care indicators for a resuscitation unit: A descriptive study and proposal
(Lippincott, Williams & Wilkins, 2018)There are lack of indicators of quality of care in resuscitation units of emergency departments. With the aim of proposing a series of indicators to evaluate the quality of care delivered in hospital resuscitation areas, ... -
El alta voluntaria y la fuga en los servicios de urgencias: un reto con implicaciones éticas y médico-legales
(Sociedad Española de Medicina de Urgencias y Emergencias (SEMES), 2018) -
proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing
(BMC, 2018)Alzheimer disease (AD) is a complex pathology related to multiple causes including oxidative stress. Brain-derived neurotrophic factor (BDNF) is a neutrotrophic factor essential for the survival and differentiation of ... -
Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia
(Springer Verlag, 2018)Neonatal anoxia-ischemia (AI) particularly affects the central nervous system. Despite the many treatments that have been tested, none of them has proven to be completely successful. Palmitoylethanolamide (PEA) and ... -
Modeling General, Specific, and Method Variance in Personality Measures: Results for ZKA-PQ and NEO-PI-R
(Sage Publications, 2018)Contemporary models of personality assume a hierarchical structure in which broader traits contain narrower traits. Individual differences in response styles also constitute a source of score variance. In this study, the ... -
Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure
(Elsevier, 2018)Changes in endogenous cannabinoid homeostasis are associated with both ethanol-related neuroinflammation and memory decline. Extensive research is still required to unveil the role of endocannabinoid signaling activation ... -
Neuroticism is associated with reduced oxygenation levels in the lateral prefrontal cortex following exposure to unpleasant images
(Elsevier, 2019)The aim of this study was to explore the prefrontal cortex response to emotional salient stimuli in subjects with high scores in Neuroticism (and low in Sensation Seeking) or high scores in Sensation Seeking (and low in ... -
Laboratory sample stability. Is it possible to define a consensus stability function? An example of five blood magnitudes
(2018-05-05)Background: The stability limit of an analyte in a biological sample can be defined as the time required until a measured property acquires a bias higher than a defined specification. Many studies assessing stability and ... -
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence
(Karger Publishers Open Access, 2018-11-18)Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship ... -
Non-invasive imaging techniques and assessment of carotid vasa vasorum neovascularization: promises and pitfalls
(Elsevier, 2018)Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization ... -
Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice
(Springer Verlag, 2018)Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ... -
Relationship between low levels of circulating TRAIL and atheromatosis progression in patients with chronic kidney disease.
(Public Library of Science, 2018-09-11)Background: Chronic kidney disease (CKD) patients experience a high risk of cardiovascular disease (CV); however, the factors involved in CV-related morbidity and mortality in these patients have not been fully defined. ... -
Influenza vaccine effectiveness in reducing severe outcomes over six influenza seasons, a case-case analysis, Spain, 2010/11 to 2015/16
(European Centre for Disease Prevention and Control, 2018) -
Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QOMadrid
(BioMed Central, 2014)[Background]: Severe Alpha-1 Antitrypsin (AAT) deficiency is a hereditary condition caused by mutations in the SERPINA1 gene, which predisposes to lung emphysema and liver disease. It is usually related to PI*Z alleles, ... -
Long lifespans have evolved with long and monounsaturated fatty acids in birds
(Society for the Study of EvolutionWiley, 2015)The evolution of lifespan is a central question in evolutionary biology, begging the question why there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of ageing. Here, we ...