L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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  • A genome-wide transcriptional study reveals that iron deficiency inhibits the yeast TORC1 pathway 

    Romero, Antonia María; Ramos-Alonso, Lucía; Montellá-Manuel, Sandra; García-Martínez, José; Torre Ruiz, M. A. de la; Pérez-Ortín, José E.; Martínez-Pastor, María Teresa; Puig, Sergi (Elsevier, 2019-09)
    Iron is an essential micronutrient that participates as a cofactor in a broad range of metabolic processes including mitochondrial respiration, DNA replication, protein translation and lipid biosynthesis. Adaptation to ...
  • Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes? 

    López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Barbé Illa, Ferran; Sánchez Peña, Enric; Hernández García, Marta; Martí, Raquel; Ceperuelo-Mallafre, Vicky; Dalmases, Mireia; Fernández-Veledo, Sonia; Vendrell, Joan; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2020)
    Limited reports exist on the relationships between regulation of oxygen homeostasis and circadian clock genes in type 2 diabetes. We examined whether the expression of Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α ...
  • Advanced lipoprotein profle disturbances in type 1 diabetes mellitus: a focus on LDL particles 

    Amor, Antonio J.; Castelblanco Echavarría, Esmeralda; Hernández, Marta; Gimenez, Marga; Granado Casas, Minerva; Blanco, Jesús; Soldevila, Berta; Esmatjes, Enric; Conget, Ignacio; Alonso, Núria; Ortega, Emilio; Mauricio Puente, Dídac (BioMed Central, 2020)
    Background: Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profle in T1DM individuals, and analysed ...
  • Adaptation and Validation of the Diabetic Foot Ulcer Scale-Short Form in Spanish Subjects 

    Martínez González, María Dolores; Dòria, Montserrat; Martínez Alonso, Montserrat; Alcubierre Calvo, Núria; Valls, Joan; Verdú-Soriano, José; Granado Casas, Minerva; Mauricio Puente, Dídac (MDPI, 2020)
    Diabetic foot ulcer (DFU) is a chronic complication that negatively affects the quality of life (QoL) of diabetic patients. In Spain, there is no specifically designed and validated instrument to assess the QoL of patients ...
  • Obesity attenuates the efect of sleep apnea on active TGF‑ß1 levels and tumor aggressiveness in patients with melanoma 

    Cubillos‑Zapata, Carolina; Martínez‑García, Miguel Ángel; Díaz‑García, Elena; Jaureguizar, Ana; Campos‑Rodríguez, Francisco; Sánchez de la Torre, Manuel; Nagore, Eduardo; Martorell‑Calatayud, Antonio; Hernández Blasco, Luis; Pastor, Esther; Abad-Capa, Jorge; Montserrat, Josep Maria; Cabriada‑Nuño, Valentín; Cano‑Pumarega, Irene; Corral-Peñafiel, Jaime; Arias, Eva; Mediano, Olga; Somoza, María; Dalmau-Arias, Joan; Almendros, Isaac; Farré, Ramon; López‑Collazo, Eduardo; Gozal, David; García Río, Francisco (Nature Research, 2020)
    Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases ...
  • Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity 

    Ballester, Maria; Quintanilla, Raquel; Ortega, Francisco J.; Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Rodríguez-Palmero, Maria; Moreno-Muñoz, José A.; Portero Otín, Manuel; Tibau, Joan (Nature Research, 2020)
    Global prevalence of obesity has increased to epidemic proportions over the past 40 years, with childhood obesity reaching alarming rates. In this study, we determined changes in liver and adipose tissue transcriptomes of ...
  • New Metrics to Assess Type 2 Diabetes after Bariatric Surgery: The “Time-Within-Remission Range” 

    de Hollanda, Ana; Lecube Torelló, Albert; Rubio, Miguel Ángel; Sánchez Peña, Enric; Vilarrasa, Núria; Gregorio Oliva, José; Fernández-Soto, María Luisa; Salas-Salvadó, Jordi; Ballesteros-Pomar, María D.; Ciudin, Andreea; Torres, Ferran; Vidal, Concepción; Morales, María José; Valdés, Sergio; Pellitero, Silvia; Miñambres, Inka; Masmiquel, Lluís; Goday, Albert; Suarez, Lorena; Flores, Liliam; Bueno Díez, Marta; Caixàs, Assumpta; Bretón, Irene; Cámara, Rosa; Olbeyra, Romina; Penso, Rona; de la Cruz, María José; Simó-Servat, Andreu; Pereyra-García, Francisca María; López-Mezquita, Elena Teresa; Gils, Anna; Fidilio, Enzamaria; Bandrés, Orosia; Martínez, Ángel; Abuín, Jose; Marques-Pamies, Montserrat; Tuneu, Laura; Arteaga, Magdalena; Castañer, Olga; Goñi, Fernando; Arrizabalaga, Cristina; Botana, Manuel Antonio; Calañas, Alfonso (MDPI, 2020)
    Almost one third of patients do not achieve type 2 diabetes remission after bariatric surgery or are unable to sustain this effect long term. Our objective was to delve further into the dynamic responses of diabetes after ...
  • Factors Accounting for Obesity and Its Perception among the Adult Spanish Population: Data from 1,000 Computer-Assisted Telephone Interviews 

    Lecube Torelló, Albert; Sánchez Peña, Enric; Monereo, Susana; Medina-Gómez, Gema; Bellido, Diego; García-Almeida, José Manuel; Martínez de Icaya, Purificación; Malagón, Maria Mar; Goday, Albert; Tinahones, Francisco José (Karger Publishers, 2020)
    Objective: Our aim was to go deeper in the self-perception of weight and health status among the Spanish population, together with the connections of familiar relationships, physical activity practice, nutritional habits, ...
  • Induced neuroprotection by remote ischemic perconditioning as a new paradigm in ischemic stroke at the acute phase, a systematic review 

    Purroy Garcia, Francisco; García, Cristina; Mauri-Capdevila, Gerard; Pereira, Cristina; Torres, Coral; Vazquez-Justes, Daniel; Vicente-Pascual, Mikel; Vena Martínez, Ana Belén; Arque, Gloria (BMC, 2020)
    Background: Remote ischemic conditioning during cerebral ischemia (remote ischemic perconditioning, RIPerC) refers to the application of several cycles of brief ischemia and reperfusion (I/R) commonly to a limb, and it ...
  • Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study 

    Gutiérrez Carrasquilla, Liliana; López Cano, Carolina; Sánchez Peña, Enric; Barbé Illa, Ferran; Dalmases, Mireia; Hernández García, Marta; Campos, Angela; Gaeta, Anna Michela; Carmona, Paola; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2020)
    Type 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 ...
  • Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study 

    Sánchez Peña, Enric; Mizab, Chadia; Sauret, Ariadna; Barbé Illa, Ferran; Martí, Raquel; López Cano, Carolina; Hernández García, Marta; Gutiérrez Carrasquilla, Liliana; Carmona, Paola; González, Jessica; Dalmases, Mireia; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2020)
    In order to compare spirometric maneuvers in adults according to the presence of type 1 diabetes, a case-control study including 75 patients with type 1 diabetes and 75 controls matched by sex, age, and body mass index ...
  • Hospital-acquired influenza infections detected by a surveillance system over six seasons, from 2010/2011 to 2015/2016 

    Godoy i García, Pere; Torner Gràcia, Núria; Soldevila, Núria; Rius, C.; Jane, M.; Martínez, Ana; Caylà, Joan A.; Domínguez García, Àngela (BioMed Central, 2020)
    Background: In addition to outbreaks of nosocomial influenza, sporadic nosocomial influenza infections also occur but are generally not reported in the literature. This study aimed to determine the epidemiologic ...
  • Are Obesity Indices Useful for Detecting Subclinical Atheromatosis in a Middle-Aged Population? 

    Sánchez Peña, Enric; Sánchez, Marta; Betriu i Bars, M. Àngels; Rius, Ferran; Torres, Gerard; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Ortega, Marta; López Cano, Carolina; Hernández García, Marta; Bueno Díez, Marta; Fernández i Giráldez, Elvira; Salvador, Javier; Lecube Torelló, Albert; ILERVAS project collaborators (Karger Publishers, 2020)
    Objective: There is a close relationship between excess adiposity and cardiovascular disease. Although body mass index (BMI) is the most used approach to estimate excess weight, other anthropometric indices have been ...
  • Dynamics of Anthropometric Indices in a Large Paired Cohort With 10 Years of Follow-Up: Paving the Way to Sarcopenic Obesity 

    Santos, Maria-Dolores; Buti, Miquel; López Cano, Carolina; Sánchez Peña, Enric; Vidal, Antonieta; Hernández García, Marta; Lafarga, Antonia; Gutiérrez Carrasquilla, Liliana; Rius, Ferran; Bueno Díez, Marta; Lecube Torelló, Albert (Frontiers Media, 2020)
    Introduction: Paired cohort investigations assessing the evolution of anthropometric indices are scarce. Here we assessed the 10-year evolution of BMI, total body fat, and lean body mass in 50,019 participants aged 18–90 ...
  • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

    Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (2020)
    Background: The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods: We performed a survey addressed ...
  • The rise of T-type channels in melanoma progression and chemotherapeutic resistance 

    Alza, Lía; Visa Pretel, Anna; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2020-04-07)
    Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the B-Raf and NRas genes. MAPK inhibitors are effective only shortterm, and recurrence occurs ...
  • Witnessed resuscitation of adult and paediatric hospital patients: An umbrella review of the evidence 

    Tíscar González, Verónica; Gea Sánchez, Montserrat; Blanco Blanco, Joan; Pastells-Peiró, Roland; De Ríos-Briz, Nuria; Moreno-Casbas, Maria Teresa (Elsevier, 2020-08-07)
    Objective To examine the research evidence about whether families were allowed to witness cardiopulmonary resuscitation on hospitalised adult and paediatric patients; and the views of patients, families and health ...
  • Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors 

    Campbell,Kyra; Rossi,Fabrizio; Adams, Jamie; Pitsidianaki, Ioanna; Barriga, Francisco M.; Garcia-Gerique, Laura; Batlle, Eduard; Casanova, Jordi; Casali, Andreu (Nature Research, 2019-05-24)
    Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to the lack of models in vivo. Here we show that expression of the EMT master inducer Snail in primary adult Drosophila ...
  • Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model 

    Berciano, Maria T.; Puente-Bedia, Alba; Medina‑Samamé, Almundena; Rodriguez-Rey, José C.; Calderó i Pardo, Jordi; Lafarga, Miguel; Tapia, Olga (Nature Publishing Group, 2020)
    Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease characterized by degeneration of spinal cord alpha motor neurons (αMNs). SMA is caused by the homozygous deletion or mutation of the ...
  • Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models 

    Fuente Ruiz, Sandra de la; Sansa Zaragoza, Alba; Hidalgo, Iván; Vivancos, Nuria; Romero-Guevara, Ricardo; Garcera, Ana; Soler i Tatché, Rosa Ma. (Springer Nature, 2020-06-25)
    Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by loss of the survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration of spinal cord motoneurons (MNs), progressive skeletal ...

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