L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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  • Effect of information about the benefits and harms of mammography on women's decision making: The InforMa randomised controlled trial 

    Pérez Lacasta, María José; Martínez Alonso, Montserrat; Garcia, Montse; Sala, Maria; Perestelo Pérez, Lilisbeth; Vidal, Carmen; Codern-Bové, Núria; Feijoo Cid, Maria; Toledo Chávarri, Ana; Cardona, Àngels; Pons, Anna; Carles Lavila, Misericordia; Rué i Monné, Montserrat (Public Library of Science, 2019-03-26)
    BACKGROUND: In Spain, women invited to breast screening are not usually informed about potential harms of screening. The objective of the InforMa study is to assess the effect of receiving information about the benefits ...
  • Evolutionary and developmental contributions for understanding the organization of the basal ganglia 

    Medina Hernández, Loreta Mª; Abellán Ródenas, Antonio; Vicario Andrade, Alba; Desfilis, Ester (Karger, 2014-04-24)
    Herein we take advantage of the evolutionary developmental biology approach in order to improve our understanding of both the functional organization and the evolution of the basal ganglia, with a particular focus on the ...
  • The influence of an educational internet-based intervention in the beliefs and attitudes of primary care professionals on non-specific chronic low back pain: study protocol of a mixed methods approach 

    García-Martínez, Ester; Soler González, Jorge; Rubí Carnacea, Francesc; García-Martínez, Beatriz; Climent-Sanz, Carolina; Blanco Blanco, Joan; Valenzuela Pascual, Francesc (BMC, 2019)
    Background: Personal convictions in referral to pain cause misbeliefs in health professionals, which can influence patients who suffer from non-specific chronic low back pain. Likewise, health professionals’ beliefs affect ...
  • Effects of Mediterranean Diet and Physical Activity on Pulmonary Function: A Cross-Sectional Analysis in the ILERVAS Project 

    Gutiérrez Carrasquilla, Liliana; Sánchez Peña, Enric; Hernández García, Marta; Polanco, Dinora; Salas-Salvadó, Jordi; Betriu i Bars, M. Àngels; Gaeta, Anna Michela; Carmona, Paola; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Farràs, Cristina; López Cano, Carolina; Fernández i Giráldez, Elvira; Lecube Torelló, Albert (MDPI, 2019)
    A few studies showed that both adherence to Mediterranean diet (MedDiet) and physical activity practice have a positive impact on pulmonary function in subjects with lung disease. These associations are not well studied ...
  • The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum 

    López Cano, Carolina; Rius, Ferran; Sánchez Peña, Enric; Gaeta, Anna Michela; Betriu i Bars, M. Àngels; Fernández i Giráldez, Elvira; Yeramian Hakim, Andree; Hernández García, Marta; Bueno Díez, Marta; Gutiérrez Carrasquilla, Liliana; Dalmases, Mireia; Lecube Torelló, Albert (Public Library of Science, 2019)
    Subjects with sleep apnea-hypopnea syndrome (SAHS) show an increased carotid intima-media thickness. However, no data exist about earlier markers of atheromatous disease, such as the proliferation and expansion of the ...
  • Nursing knowledge of and attitude in cardiopulmonary arrest: cross-sectional survey analysis 

    Tíscar González, Verónica; Blanco Blanco, Joan; Gea Sánchez, Montserrat; Rodriguez-Molinuevo, Ascensión; Moreno-Casbas, Maria Teresa (PeerJ, 2019)
    Background Nurses are often the first to activate the chain of survival when a cardiorespiratory arrest happens. That is why it is crucial that they keep their knowledge and skills up-to-date and their attitudes to ...
  • Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis 

    Marquez Exposito, Laura; Lavoz, Carolina; Rodrigues-Diez, Raul; Rayego Mateos, Sandra; Orejudo, Macarena; Cantero-Navarro, Elena; Ortiz, Alberto; Egido, Jesús; Selgas, Rafael; Mezzano, Sergio; Ruiz-Ortega, Marta (Frontiers Media, 2018)
    Chronic kidney disease (CKD) is emerging as an important health problem due to the increase number of CKD patients and the absence of an effective curative treatment. Gremlin has been proposed as a novel therapeutic target ...
  • Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment 

    Georgouli, Mirella; Herraiz, Cecilia; Crosas-Molist, Eva; Fanshawe, Bruce; Maiques Carlos, Oscar; Perdrix, Anna; Pandya, Pahini; Rodríguez Hernández, Irene; Ilieva, Kristina M.; Cantelli, Gaia; Karagiannis, Panagiotis; Mele, Silvia; Lam, Hoyin; Josephs, Debra H.; Matias-Guiu, Xavier; Martí Laborda, Rosa Ma.; Nestle, Frank O.; Orgaz, Jose L.; Malanchi, Ilaria; Fruhwirth, Gilbert O.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2019)
    ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant ...
  • Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study. 

    Fernández Armenteros, José Manuel; Gómez Arbonés, Javier; Buti-Soler, M.; Betriu i Bars, M. Àngels; Sanmartín Novell, Verònica; Ortega Bravo, Marta; Martínez Alonso, Montserrat; Garí Marsol, Eloi; Portero Otín, Manuel; Santamaria-Babi, L.; Casanova i Seuma, Josep M. (Josep Manel) (Wiley, 2019)
    Abstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and ...
  • Exceptional human longevity is associated with a specific plasma phenotype of ether lipids 

    Pradas Barriga, Irene; Jové Font, Mariona; Huynh, Karina; Puig Farré, Josep; Inglés, Marta; Borràs, Consuelo; Viña Ribes, José; Meikle, Peter J.; Pamplona Gras, Reinald (Elsevier, 2019)
    A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to ...
  • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

    Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
    β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
  • Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology 

    Morgado-Pascual, José L.; Marchant, Vanessa; Dolade, Nuria; Rodrigues-Diez, Raul; Suarez-Alvarez, Beatriz; Kerr, Bredford; Valdivielso Revilla, José Manuel; Ruiz-Ortega, Marta; Rayego Mateos, Sandra (Hindawi Publishing Corporation, 2018)
    The growing incidence of obesity, hypertension, and diabetes, coupled with the aging of the population, is increasing the prevalence of renal diseases in our society. Chronic kidney disease (CKD) is characterized by ...
  • Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium 

    Chang, Alex R.; Grams, Morgan E.; Ballew, Shoshana H.; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M.; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J.; Li, Yuanying; Navaneethan, Sankar D.; Roderick, Paul J; Valdivielso Revilla, José Manuel; Visseren, Frank L. J.; Zhang, Luxia; Gansevoort, Ron T.; Hallan, Stein I.; Levey, Andrew S.; Matsushita, Kunihiro; Shalev, Varda; Woodward, Mark (BMJ Publishing Group, 2019)
    OBJECTIVE To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality. DESIGN ...
  • The Spanish Society of Nephrology (SENEFRO) commentary to the Spain GBD 2016 report: Keeping chronic kidney disease out of sight of health authorities will only magnify the problem 

    Ortiz, Alberto; Sanchez-Niño, Maria-Dolores; Crespo-Barrio, Marta; De-Sequera-Ortiz, Patricia; Fernández i Giráldez, Elvira; García-Maset, Rafael; Macía-Heras, Manuel; Pérez Fontán, Miguel; Rodríguez, Mariano; Salgueira-Lazo, Mercedes; Sánchez Alvarez, Emilio; Santamaría-Olmo, Rafael; Simal-Blanco, Fernando; Pino, María Dolores del (Elsevier, 2019)
    The Global Burden of Disease (GBD) study measures the health of populations worldwide and by country on an annual basis and aims at helping guide public policy on health issues. The GBD estimates for Spain in 2016 and ...
  • Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target 

    Jové Font, Mariona; Pradas Barriga, Irene; Dominguez Gonzalez, Mayelin; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2018)
    The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...
  • Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage 

    Rayego Mateos, Sandra; Rodrigues-Diez, Raul; Morgado-Pascual, José L.; Valentijn, Floris; Valdivielso Revilla, José Manuel; Goldschmeding, Roel; Ruiz-Ortega, Marta (Hindawi Publishing Corporation, 2018)
    Chronickidneydisease (CKD)ischaracterized bypersistent inflammationandprogressive fibrosis,ultimatelyleadingto end-stage renal disease. Although many studies have investigated the factors involved in the progressive deterioration ...
  • The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells 

    Enguita, Mónica; Razquin, Nerea; Pamplona Gras, Reinald; Quiroga, Jorge; Prieto, Jesús; Fortes, Puri (Nature Research, 2019)
    Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive ...
  • Effectiveness of a telephone-based intervention for smoking cessation in patients with severe mental disorders: study protocol for a randomized controlled trial 

    Ballbè, Montse; Martínez Martínez, Cristina; Feliu, Ariadna; Torres, Núria; Nieva, Gemma; Pinet, Cristina; Raich, Antònia; Mondon, Sílvia; Barrio, Pablo; Hernández-Ribas, Rosa; Vicens, Jordi; Costa, Sílvia; Vilaplana, Jordi; Alaustre, Laura; Vilalta, Eva; Blanch, Roser; Subirà, Susana; Bruguera, Eugeni; Suelves, Josep Maria; Guydish, Joseph; Fernandez, Esteve (BMC, 2019)
    Background Up to 75% of inpatients with mental disorders smoke, and their life expectancy is decreased by up to 25 years compared to the general population. Hospitalized patients without monitoring after discharge quickly ...
  • Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS 

    Rando, Amaya; Torre, Miriam de la; Martinez-Muriana, Anna; Zaragoza, Pilar; Musaro, Antonio; Hernández i Estanyol, Sara; Navarro, Xavier; Toivonen, Janne M.; Osta, Rosario (Public Library of Science, 2019)
    Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ...
  • Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum 

    Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Wang, Hongyin; Aldea, Martí; Garí Marsol, Eloi (American Society for Biochemistry and Molecular Biology, 2008)
    Whi3 is an RNA-binding protein associated with the endoplasmic reticulum (ER) that binds the CLN3 mRNA and plays a key role in the efficient retention of cyclin Cln3 at the ER. In the present work, we have identified new ...

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