L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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  • Melanoma transplants in “green” mice: Fluorescent cells in tumors are not equivalent to host-derived cells 

    García-Olmo, Dolores C.; Picazo, María G.; García-Olmo, Damián (Elsevier, 2018)
    Background: To examine the usefulness of green fluorescent protein (GFP) mice for studying the interactions between normal cells and tumor cells in a host, we used a melanoma model in such “green” mice [C57BL/6-Tg(CAG-EGFP)1Osb ...
  • Diálisis peritoneal incremental: resultados clínicos y preservación de la función renal residual 

    Borràs, Mercè; Chacón, Andrea; Cerdá Vilaplana, Carla; Usón Nuño, Ana; Fernández i Giráldez, Elvira (Sociedad Española de NefrologíaElsevier, 2016)
    Introducción: En los últimos años el inicio de diálisis peritoneal (DP) con 3 recambios se ha convertido en una práctica habitual, aunque se dispone de pocos resultados clínicos publicados. Objetivo: Descripción de la ...
  • Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness 

    Cambray Carner, Serafí; Ibarz Escuer, Mercedes; Bermúdez López, Marcelino; Marti Antonio, Manuel; Bozić Stanojević, Milica; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (MDPI, 2020)
    Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with ...
  • Study design of Heart failure Events reduction withRemote Monitoring and eHealth Support (HERMeS) 

    Yun, Sergi; Enjuanes, Cristina; Calero, Esther; Hidalgo, Encarnación; Cobo, Marta; Llàcer, Pau; García Pinilla, José Manuel; González Franco, Álvaro; Núñez, Julio; Morales Rull, José Luis; Beltrán, Paola; Delso, Cristina; Freixa Pamias, Román; Moliner, Pedro; Corbella, Xavier; Comín Colet, Josep (Wiley Open Access, 2020)
    Aims. The role of non-invasive telemedicine (TM) combining telemonitoring and teleintervention by videoconference (VC) in patients recently admitted due to heart failure (HF) (‘vulnerable phase’ HF patients) is not well ...
  • Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation 

    Sarlabous Uranga, Leonardo; Aquino Esperanza, Jose; Magrans, Rudys; de Haro, Candelaria; López-Aguilar, Josefina; Subirà, Carles; Batlle, Montserrat; Rué i Monné, Montserrat; Gomà Fernández, Gemma; Ochagavía, Ana; Fernández, Rafael; Blanch, Lluís (Scientific Reports, 2020)
    Patient-ventilator asynchronies can be detected by close monitoring of ventilator screens by clinicians or through automated algorithms. However, detecting complex patient-ventilator interactions (CP-VI), consisting of ...
  • Multidisciplinary virtual management of pulmonary nodules 

    Polanco, Dinora; González, Jessica; Gracia-Lavedan, Esther; Pinilla, Lucía; Plana, R.; Molina, M.; Pardina Solano, Marina Asunción; Barbé Illa, Ferran (ElsevierSociedade Portuguesa de Pneumologia, 2022)
    Introduction and objectives: Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the ...
  • Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients 

    Molinero, Marta; Benítez, Iván; González, Jessica; Gort Paniello, Clara; Moncusí Moix, Anna; Rodríguez Jara, Fátima; García Hidalgo, María C.; Torres, Gerard; Vengoechea Aragoncillo, José Javier; Gómez Falguera, Silvia; Cabo Gambín, Ramón; Caballero, Jesús; Bermejo Martin, Jesús F.; Ceccato, Adrián; Fernández Barat, Laia; Ferrer, Ricard; García Gasulla, Dario; Menéndez, Rosario; Motos, Anna; Peñuelas, Oscar; Riera, Jordi; Torres, Antoni; Barbé Illa, Ferran; de Gonzalo Calvo, David (Frontiers Media, 2022)
    Background: The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile of bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients ...
  • Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing 

    Sánchez Peña, Enric; Sapiña Beltrán, Esther; Gavaldá, Ricard; Barbé Illa, Ferran; Torres, Gerard; Sauret, Ariadna; Dalmases, Mireia; López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Castro-Boqué, Eva; Farràs-Sallés, Cristina; Pamplona Gras, Reinald; Mauricio Puente, Dídac; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2022)
    Type 2 diabetes leads to severe nocturnal hypoxemia, with an increase in apnea events and daytime sleepiness. Hence, we assessed sleep breathing parameters in the prediabetes stage. A cross-sectional study conducted on 966 ...
  • ICU-Acquired Pneumonia Is Associated with Poor HealthPost-COVID-19 Syndrome 

    Martín Loeches, Ignacio; Motos, Anna; Menéndez, Rosario; Gabarrús, Albert; González, Jessica; Fernández Barat, Laia; Ceccato, Adrián; Pérez Arnal, Raquel; García Gasulla, Dario; Ferrer, Ricard; Riera, Jordi; Lorente, José Ángel; Peñuelas, Oscar; Bermejo Martin, Jesús F.; de Gonzalo Calvo, David; Rodríguez, Alejandro; Barbé Illa, Ferran; Aguilera, Luciano; Amaya Villar, Rosario; Barberà, Carme; Barberán, José; Blandino Ortiz, Aaron; Bustamante Munguira, Elena; Caballero, Jesús; Carbajales, Cristina; Carbonell, Nieves; Catalán González, Mercedes; Galbán, Cristóbal; Gumucio Sanguino, Víctor D.; de la Torre, Maria del Carmen; Díaz, Emili; Gallego, Elena; García Garmendia, José Luis; Garnacho Montero, José; Gómez, José Manuel; Jorge García, Ruth Noemí; Loza Vázquez, Ana; Marin Corral, Judith; Martínez de la Gándara, Amalia; Martínez Varela, Ignacio; López Messa, Juan; Albaiceta, Guillermo M.; Novo, Mariana Andrea; Peñasco, Yhivian; Ricart, Pilar; Urrelo Cerrón, Luis; Sánchez Miralles, Angel; Sancho Chinesta, Susana; Socias, Lorenzo; Solé Violan, Jordi; Tamayo Lomas, Luis; Vidal, Pablo; Torres, Antoni (MDPI, 2021)
    Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to ...
  • The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer's disease patients 

    Targa, Adriano; Benítez, Iván; Dakterzada, Farida; Fontenele Araujo, John; Minguez Roure, Olga; Zetterberg, Henrik; Blennow, Kaj; Barbé Illa, Ferran; Piñol Ripoll, Gerard (BMC, 2021)
    Background:Alterations in circadian rhythms are present in the presymptomatic stage of Alzheimer’s disease (AD),possibly contributing to its pathogenesis. However, it is unknown whether such alterations are associated ...
  • Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID‑19 

    Bermejo Martin, Jesús F.; González Rivera, Milagros; Almansa, Raquel; Micheloud, Dariela; Tedim, Ana P.; Domínguez Gil, Marta; Resino, Salvador; Martín Fernández, Marta; Murua, Pablo Ryan; Pérez García, Felipe; Tamayo Lomas, Luis; López Izquierdo, Raúl; Bustamante Munguira, Elena; Aldecoa, César; Gómez, José Manuel; Rico Feijoo, Jesús; Orduña, Antonio; Méndez, Raúl; Fernández Natal, Isabel; Megías, Gregoria; González Estecha, Montserrat; Carriedo, Demetrio; Doncel, Cristina; Jorge, Noelia; Ortega, Alicia; Fuente, Amanda de la; Campo, Félix del; Fernández Ratero, José Antonio; Trapiello, Wysali; González Jiménez, Paula; Ruiz, Guadalupe; Kelvin, Alyson A.; Toloue Ostadgavahi, Ali; Oneizat, Ruth; Ruiz, Luz María; Miguéns, Iria; Gargallo, Esther; Muñoz, Ioana; Pelegrin, Sara; Martín, Silvia; García Olivares, Pablo; Cedeño, Jamil Antonio; Ruiz Albi, Tomás; Puertas, Carolina; Berezo, Jose Ángel; Renedo, Gloria; Herrán, Rubén; Bustamante Munguira, Juan; Enríquez, Pedro; Cicuendez, Ramón; Blanco, Jesús; Abadia, Jesica; Gómez Barquero, Julia; Mamolar, Nuria; Blanca López, Natalia; Valdivia, Luis Jorge; Fernández Caso, Belén; Mantecón, María Ángeles; Motos, Anna; Fernandez Barat, Laia; Ferrer, Ricard; Barbé Illa, Ferran; Torres, Antoni; Menéndez, Rosario; Eiros, José María; Kelvin, David J. (BMC, 2020)
    Background. COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host ...
  • Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort 

    Zuil, María; Benítez, Iván; Cabo Gambín, Ramón; Manzano Senra, Carlos; Moncusí Moix, Anna; Gort Paniello, Clara; de Gonzalo Calvo, David; Molinero, Marta; Vengoechea Aragoncillo, José Javier; Comella, Thais; Batlle Garcia, Jordi de; Torres, Gerard; Torres, Antoni; Barbé Illa, Ferran; González, Jessica (Public Library of Science, 2021)
    The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total ...
  • Identification and validation of endogenous control miRNAs in plasma samples for normalization of qPCR data for Alzheimer's disease 

    Dakterzada, Farida; Targa, Adriano; Benítez, Iván; Romero El Khayat, Leila; de Gonzalo Calvo, David; Torres, Gerard; Moncusí Moix, Anna; Huerto Vilas, Raquel; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Piñol Ripoll, Gerard (BCM, 2020)
    Background. MicroRNAs (miRNAs) are noncoding RNAs that are highly relevant as disease biomarkers. Several studies that explored the role of miRNAs in Alzheimer’s disease (AD) demonstrated their usefulness in clinical ...
  • Gut epithelial barrier markers in patients with obstructive sleep apnea 

    Barceló Bennasar, Antònia; Esquinas López, Cristina; Robles, Juan; Piérola, Javier; Peña, Mónica de la; Aguilar, Irene; Morell Garcia, Daniel; Alonso, Alberto; Toledo Pons, Nuria; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Elsevier, 2016)
    Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest ...
  • Effect of CPAP on blood pressure in patients with minimally symptomatic obstructive sleep apnoea: a meta-analysis using individual patient data from four randomised controlled trials 

    Bratton, Daniel J.; Stradling, John R.; Barbé Illa, Ferran; Kohler, Malcolm (BMJ Publishing Group, 2014)
    Background. CPAP reduces blood pressure (BP) in patients with symptomatic obstructive sleep apnoea (OSA). Whether the same benefit is present in patients with minimally symptomatic OSA is unclear, thus a meta-analysis of ...
  • Non-occupational protein contact dermatitis induced by mango fruit 

    Pesqué, David; Canal Garcia, Elena; Rozas-Muñoz, Eduardo; Pujol Vallverdú, Ramon M.; Giménez Arnau, Ana M. (John Wiley & Sons Ltd, 2021-06)
    Immediate contact skin reactions are considered a subset of the contact urticaria syndrome, which includes contact urticaria and protein contact dermatitis (PCD). These entities clinically manifest as development of wheals, ...
  • Locating the Dark Triad in a MultidimensionalPersonality Space 

    Naor-Ziv, Revital; Glicksohn, Joseph; Aluja Fabregat, Antón (Cambridge University Press, 2022)
    The Dark Triad traits of Psychopathy, Machiavellianism, and Narcissism should be clearly recognizable within a multidimensional personality space. Two such personality spaces were investigated in this study: HEXACO ...
  • Precise Mapping of Otp Expressing Cells Across Different Pallial Regions Throughout Ontogenesis Using Otp-Specific Reporter Transgenic Mice 

    Morales, Lorena; González Alonso, Alba; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media, 2022)
    Taking advantage of two Otp-specific reporter lines of transgenic mice (Otp-eGFP and Otp-Cre; Rpl22-HA), we identify and describe different Otp cell populations across various pallial regions, including the pallial amygdala, ...
  • Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study 

    Sánchez Peña, Enric; Kerkeni, M.; Hernández García, Marta; Gavaldá, Ricard; Rius, Ferran; Sauret, Ariadna; Torres, Gerard; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Castro-Boqué, Eva; Purroy Garcia, Francisco; Mauricio Puente, Dídac; Farràs-Sallés, Cristina; Buti, Miquel; Godoy i García, Pere; Pamplona Gras, Reinald; Lecube Torelló, Albert (MDPI, 2022)
    A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation ...
  • Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children 

    Altet, Neus; Latorre, Irene; Jiménez-Fuentes, María Ángeles; Soriano Arandes, Antoni; Villar-Hernández, Raquel; Milà, Celia; Rodríguez Fernández, Pablo; Muriel Moreno, Beatriz; Comella-Del-Barrio, Patricia; Godoy i García, Pere; Millet, Joan Pau; de Souza-Galvão, Maria Luiza; Jiménez-Ruiz, Carlos A.; Domínguez, Jose (MDPI, 2022)
    Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing ...

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