L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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  • Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project 

    Sánchez Peña, Enric; Betriu i Bars, M. Àngels; López Cano, Carolina; Hernández García, Marta; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Bermúdez López, Marcelino; Farràs-Sallés, Cristina; Barril, Silvia; Pamplona Gras, Reinald; Rius, Ferran; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (BioMed Central, 2019-11-15)
    BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the ...
  • Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms 

    Bahhir, Diana; Yalgin, Cagri; Ots, Liina; Järvinen, Sampsa; George, Jack; Naudí i Farré, Alba; Krama, Tatjana; Krams, Indrikis; Tamm, Mairi; Andjelković, Ana; Dufour, Eric; González de Cosar, Jose M.; Gerards, Mike; Parhiala, Mikael; Pamplona Gras, Reinald; Jacobs, Howard T.; Jõers, Priit (Public Library of Science, 2019-10-04)
    Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ...
  • Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women 

    Pradas Barriga, Irene; Rovira-Llopis, Susana; Naudí i Farré, Alba; Bañuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Pamplona Gras, Reinald; Victor, Victor M.; Jové Font, Mariona (Nature Publishing Group, 2019-11-05)
    Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ...
  • Dissimilar impact of Mediterranean diet and physical activity on estimated body composition: A cross-sectional study from the ILERVAS project 

    Sánchez, Marta; Sánchez Peña, Enric; Hernández García, Marta; González, Jessica; Purroy Garcia, Francisco; Rius, Ferran; Pamplona Gras, Reinald; Farràs-Sallés, Cristina; Gutiérrez Carrasquilla, Liliana; Fernández i Giráldez, Elvira; Bermúdez López, Marcelino; Salvador, Javier; Salas-Salvadó, Jordi; Lecube Torelló, Albert (MDPI, 2019-06-17)
    There is a close relationship between lifestyle behaviors and excess adiposity. Althoughbody mass index (BMI) is the most used approach to estimate excess weight, other anthropometricindices have been developed to ...
  • Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis 

    Nogueras, L.; Gonzalo Benito, Hugo; Jové Font, Mariona; Sol, Joaquim; Gil-Sanchez, A.; Hervás, J.V.; Valcheva, P.; González Mingot, Cristina; Solana Moga, M. José; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Brieva Ruiz, Luis (Nature Publishing Group, 2019-08-05)
    Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The ...
  • Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia 

    Falguera, Mireia; Vilanova, María-Belén; Alcubierre Calvo, Núria; Granado Casas, Minerva; Marsal Mora, Josep Ramon; Miró, Neus; Cebrian, Cristina; Molló Inesta, Àngels; Franch-Nadal, Josep; Mata Cases, Manel; Castelblanco Echavarría, Esmeralda; Mauricio Puente, Dídac (BMJ, 2020-01-07)
    Objectives: To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to ...
  • Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus 

    Tapia, Olga; Narcís, Oriol J.; Riancho, Javier; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Elsevier, 2017)
    Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best ...
  • The Mediterranean Diet is Associated with an Improved Quality of Life in Adults with Type 1 Diabetes 

    Granado Casas, Minerva; Martín, Mariona; Martínez Alonso, Montserrat; Alcubierre Calvo, Núria; Hernández, Marta; Alonso, Núria; Castelblanco Echavarría, Esmeralda; Mauricio Puente, Dídac (MDPI, 2020-01-02)
    This study aimed to assess the potential association between dietary patterns (i.e., the Mediterranean Diet (MedDiet) and healthy eating) and patient-reported quality of life (QoL) and treatment satisfaction (TS) in adults ...
  • Glial activation and central synapse loss, but not motoneuron degeneration, are prevented by the sigma-1 receptor agonist PRE-084 in the Smn2B/- mouse model of spinal muscular atrophy 

    Cerveró Cebrià, Clàudia; Blasco Carmona, Alba; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Navarro, X. (Xavier); Esquerda Colell, Josep; Calderó i Pardo, Jordi (American Association of Neuropathologists, 2018)
    Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with concomitant muscle denervation. MN excitability and vulnerability to disease are particularly regulated by cholinergic synaptic afferents ...
  • Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair 

    Salvany, Sara; Casanovas i Llorens, Anna; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Hernández, Sara; Santafé Martínez, Manel; Soto-Bernardini, María Clara; Calderó i Pardo, Jordi; Schwab, Markus H.; Esquerda Colell, Josep (Federation of American Societies for Experimental Biology, 2019)
    C-type synaptic boutons (C-boutons) provide cholinergic afferent input to spinal cord motor neurons (MNs), which display an endoplasmic reticulum (ER)–related subsurface cistern (SSC) adjacent to their postsynaptic membrane. ...
  • A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma 

    Servià Goixart, Lluís; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (BMC (part of Springer Nature), 2019-05-22)
    Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ...
  • Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects 

    Castelblanco Echavarría, Esmeralda; Sanjurjo, Lucía; Falguera, Mireia; Hernández García, Marta; Fernandez-Real, Jose Manuel; Sarrias, Maria-Rosa; Alonso, Núria; Mauricio Puente, Dídac (MDPI, 2019-05)
    The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 ...
  • Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity 

    Vall-llaura Espinosa, Núria; Mir, Noèlia; Garrido, Lourdes; Vived Maza, Celia; Cabiscol Català, Elisa (Elsevier, 2019-06)
    Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. ...
  • Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study 

    Casasnovas, Carlos; Ruiz, Montserrat; Schlüter, Agatha; Naudí i Farré, Alba; Fourcade, Stéphane; Veciana, Misericordia; Castañer, Sara; Albertí, Antonia; Bargalló, Nuria; Johnson, Maria; Raymond, Gerald V.; Fatemi, Ali; Moser, Ann B.; Villarroya, Francesc; Portero Otín, Manuel; Artuch, Rafael; Pamplona Gras, Reinald; Pujol, Aurora (Springer Verlag, 2019-05)
    X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...
  • Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential 

    Serrano Casasola, José Carlos Enrique; Baena-Fustegueras, Juan A; Martín Garí, Meritxell; Rassendren, Helene; Cassanyé, Anna; Naudí i Farré, Alba; López Cano, Carolina; Sánchez Peña, Enric; Fuente Juárez, Mari Cruz de la; Herrería González, Fernando; Olsina Kissler, Jorge Juan; Lecube Torelló, Albert; Portero Otín, Manuel (Wiley online library, 2019-05)
    Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in ...
  • Impact of sleep health on self-perceived health status 

    Dalmases, Mireia; Benítez, Ivan D.; Sapiña-Beltran, Esther; Garcia-Codina, Oriol; Medina-Bustos, Antonia; Escarrabill, Joan; Saltó, Esteve; Buysse, Daniel J.; Plana, Rosa E.; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Batlle Garcia, Jordi de (Nature Publishing Group, 2019-05)
    Although sleep habits have long been recognized as a promoter of health, the World Health Organization 2014 report on non-communicable diseases (NCDs) only listed smoking, alcohol intake, diet and physical activity (PA) ...
  • Identification and validation of circulating miRNAs as endogenous controls in obstructive sleep apnea 

    Santamaría Martos, Fernando; Benítez, Ivan D.; Zapater, Andrea; Girón, Cristina; Pinilla, Lucía; Fernandez-Real, Jose Manuel; Barbé Illa, Ferran; Ortega, Francisco J.; Sánchez de la Torre, Manuel (Public Library of Science, 2019-03-13)
    microRNAs (miRNAs) are non-coding RNAs highly relevant as biomarkers for disease. A seminal study that explored the role of miRNAs in obstructive sleep apnea syndrome (OSA) demonstrated their usefulness in clinical management. ...
  • Migrated t lymphocytes into malignant pleural effusions: an indicator of good prognosis in lung adenocarcinoma patients 

    Nieto, Juan C.; Zamora, Carlos; Porcel Pérez, José Manuel; Mulet, Maria; Pajares, Virginia; Muñoz-Fernandez, Ana M.; Calvo, Nuria; Espinosa, Iñigo; Pascual-García, Mónica; Bielsa Martín, Silvia; Vidal, Silvia (Nature Publishing Group, 2019)
    The presence of leukocyte subpopulations in malignant pleural effusions (MPEs) can have a different impact on tumor cell proliferation and vascular leakiness, their analysis can help to understand the metastatic microenvironment. ...
  • Empathy and big five personality model inmedical students and its relationship togender and specialty preference: a cross-sectional study 

    Guilera Lladós, Teresa; Batalla, Iolanda; Forné, Carles; Soler González, Jorge (BioMed Central, 2019)
    Background:Given the influence that personality can have on empathy, this study explores the relationshipbetween empathy and personality, using three different measures of empathy, and taking into account gender andspecialty ...
  • Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1 

    García-Morales, Victoria; Rodríguez-Bey, Guillermo; Gómez-Pérez, Laura; Domínguez-Vías, Germán; González-Forero, David; Portillo, Federico; Campos-Caro, Antonio; Gento-Caro, Ángela; Issaoui, Noura; Soler i Tatché, Rosa Ma.; Garcera, Ana; Moreno-López, Bernardo (Nature Publishing Group, 2019-08-22)
    Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium ...

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