Institut de Recerca Biomèdica de Lleida (IRBLleida)
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L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].
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Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer
(MDPI, 2022)Metabolomic profiling analysis has the potential to highlight new molecules and cellular pathways that may serve as potential therapeutic targets for disease treatment. In this study, we used an LC-MS/MS platform to define, ... -
Enhancing Night and Day Circadian Contrast through Sleep Education in Prediabetes and Type 2 Diabetes Mellitus: A Randomized Controlled Trial
(MDPI, 2022)Background: Evidence supports a causal relationship between circadian disturbance and impaired glucose homeostasis. Methods: To determine the effect of an educational intervention delivered by primary care nurses to ... -
Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice
(MDPI, 2022)The sliding clamp PCNA is a multifunctional homotrimer mainly linked to DNA replication. During this process, cells must ensure an accurate and complete genome replication when constantly challenged by the presence of DNA ... -
Psychometric properties of the Spanish version of the Psychopathy Checklist: Youth Version
(Springer Nature, 2022)The current study examined the psychometric properties (factor structure, reliability and validity) of the Psychopathy Checklist: Youth Version (PCL:YV; Forth et al., 2003) in Spanish samples of male justice-involved youths ... -
Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
(Springer Nature, 2022)Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly ... -
Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial
(BMC, 2022)Background: Delaying the transition from minimal cognitive impairment to Alzheimer’s dementia is a major concern in Alzheimer’s disease (AD) therapeutics. Pathological signs of AD occur years before the onset of clinical ... -
Evolution of an Iron-Detoxifying Protein: Eukaryotic and Rickettsia Frataxins Contain a Conserved Site Which Is Not Present in Their Bacterial Homologues
(MDPI, 2022)Friedreich’s ataxia is a neurodegenerative disease caused by mutations in the frataxin gene. Frataxin homologues, including bacterial CyaY proteins, can be found in most species and play a fundamental role in mitochondrial ... -
Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy
(MDPI, 2022)This study aimed to assess whether the advanced characteristics of serum lipoprotein subclasses could better predict the risk of developing diabetic retinopathy (DR) and its severity compared to other established risk ... -
Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus
(BMC, 2022)Background Compelling evidence suggests that the fbroblast growth factor 23 (FGF23) / α-klotho axis is impaired in subjects with diabetes mellitus. We examined the relationship between parameters related to calcium/phosphate ... -
A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
(The Company of Biologists, 2022)To evaluate senescence mechanisms, including senescence associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase ... -
Factor structure of the Maslach Burnout Inventory Human Services Survey in Spanish urgency healthcare personnel: a cross-sectional study
(Springer Nature, 2022)Background: The Maslach Burnout Inventory (MBI) is an instrument commonly used to evaluate burnout syndrome. The goal of the present study was to assess the internal reliability and the performance of the items and the ... -
Peripheral venous catheter-related phlebitis: A meta-analysis of topical treatment
(Wiley, 2022-10-12)Aim To systematically evaluate the efficacy of different topical treatments for PVC-related phlebitis in hospital in-patients. Design A systematic review and meta-analysis. Methods A selection was made of experimental and ... -
High-Intensity Interval Training (HIIT) on Biological and Body Composition Variables in Patients with Musculoskeletal Disorders: A Systematic Review and Meta-Analysis
(MDPI, 2022-11-24)In order to assess the impact of high-intensity interval training (HIIT) on biological and body composition variables in patients with musculoskeletal disorders (MSKD), a systematic search on PubMed (Medline), CENTRAL, ... -
Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea
(BMC, 2022)Background: Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-infammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, ... -
Percepción de la atención sanitaria en la primera experiencia de maternidad y paternidad
(Elsevier, 2022)Objetivo: Conocer las percepciones de madres y padres primerizas/os sobre la atención sanitaria recibidadurante la transición hacia la maternidad y la paternidad.Método: Estudio cualitativo basado en 12 entrevistas ... -
Proteomic profiling of lung diffusion impairment in therecovery stage of SARS-CoV-2–induced ARDS
(John Wiley & Sons, Ltd, 2022) -
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS
(Taylor and Francis Group, 2022)There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function ... -
Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view
(European Respiratory Society, 2022)Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA), defined as the inability to stay awake during the day. Its clinical descriptors remain elusive, and the pathogenesis is complex, ... -
Molecular Mechanisms of Kidney Injury and Repair
(MDPI, 2022)Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus emphasizing the need to better understand the molecular mechanisms of damage and regeneration in the kidney. CKD predisposes to acute ... -
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection
(Frontiers Media, 2022)Introduction: Bronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making. Aim: To identify the proteomic determinants associated ...