Institut de Recerca Biomèdica de Lleida (IRBLleida)
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L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].
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Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence
(Karger Publishers Open Access, 2018-11-18)Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship ... -
Non-invasive imaging techniques and assessment of carotid vasa vasorum neovascularization: promises and pitfalls
(Elsevier, 2018)Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization ... -
Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice
(Springer Verlag, 2018)Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ... -
Relationship between low levels of circulating TRAIL and atheromatosis progression in patients with chronic kidney disease.
(Public Library of Science, 2018-09-11)Background: Chronic kidney disease (CKD) patients experience a high risk of cardiovascular disease (CV); however, the factors involved in CV-related morbidity and mortality in these patients have not been fully defined. ... -
Influenza vaccine effectiveness in reducing severe outcomes over six influenza seasons, a case-case analysis, Spain, 2010/11 to 2015/16
(European Centre for Disease Prevention and Control, 2018) -
Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QOMadrid
(BioMed Central, 2014)[Background]: Severe Alpha-1 Antitrypsin (AAT) deficiency is a hereditary condition caused by mutations in the SERPINA1 gene, which predisposes to lung emphysema and liver disease. It is usually related to PI*Z alleles, ... -
Long lifespans have evolved with long and monounsaturated fatty acids in birds
(Society for the Study of EvolutionWiley, 2015)The evolution of lifespan is a central question in evolutionary biology, begging the question why there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of ageing. Here, we ... -
Location-dependent effects of trauma on oxidative stress in humans
(Public Library of Science, 2018)Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. ... -
Effect of Pseudomonas graminis strain CPA-7 on the ability of Listeria monocytogenes and Salmonella enterica subsp. enterica to colonize Caco-2 cells after pre-incubation on fresh-cut pear
(Elsevier, 2017)To further gain insight into the mechanism by which the biopreservative bacterium Pseudomonas graminis CPA-7 develops its antimicrobial activity, we have examined the effect that the prior interaction stablished by this ... -
Iron in Friedreich Ataxia: A Central Role in the Pathophysiology or an Epiphenomenon?
(MDPI, 2018)Friedreich ataxia is a neurodegenerative disease with an autosomal recessive inheritance. In most patients, the disease is caused by the presence of trinucleotide GAA expansions in the first intron of the frataxin gene. ... -
Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
(Wiley Open Access, 2018)Fibroblast growth factor 21 (FGF21) has been proposed to be an antiaging hormone on the basis of experimental studies in rodent models. However, circulating FGF21 levels are increased with aging in rodents and humans. ... -
L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial–mesenchymal transition
(Springer Verlag, 2018)Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial–mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAMis ... -
Social environment mediates cancer progression in Drosophila
(Springer Nature, 2018)The influence of oncogenic phenomena on the ecology and evolution of animal species is becoming an important research topic. Similar to host–pathogen interactions, cancer negatively affects host fitness, which should ... -
Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP)
(Public Library of Science, 2018)Objectives Obstructive sleep apnea (OSA) is among the least studied risk factors for erectile dysfunction (ED). We aimed to determine ED prevalence in newly-diagnosed OSA patients, describe their main characteristics ... -
Patient-Derived Xenograft Models for Endometrial Cancer Research
(MDPI, 2018)Endometrial cancer (EC) is the most common malignancy of the genital tract among women in developed countries. Recently, a molecular classification of EC has been performed providing a system that, in conjunction with ... -
Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs
(Springer Verlag, 2018)Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases ... -
Exacerbations of chronic obstructive pulmonary disease: An analysis of the care process in a regional hospital emergency department
(Wolters Kluwer Health, Inc, 2018)To describe the characteristics of patients visiting a Hospital Emergency Department (HED) due to chronic obstructive pulmonary disease (COPD) exacerbation (AECOPD) and to evaluate their management. A cross-sectional ... -
Lipidomics Reveals a Tissue-Specific Fingerprint
(Frontiers Media, 2018)In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ... -
Cytokeratin profile of basal cell carcinomas according to the degree of sun exposure and to the anatomical localization
(Wolters Kluwer Health, Inc.International Society of Dermatopathology (ISDP), 2018)Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development ...