L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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  • Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer 

    Vrede, S. W.; van Weelden, W. J.; Visser, N. C. M.; Bulten, Johan; van der Putten, Louis J. M.; van de Vijver, Koen; Santacana, M.; Colas, L.; Gil-Moreno, Antonio; Moiola, Cristian P.; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, M.; Hausnerova, J.; van der Wurff, Anneke A. M.; Matias-Guiu, Xavier; Amant, Frederic; ENITEC Consortium; Snijders, Marc P. L. M.; Küsters-Vandevelde, H. V. N; Reijnen, C.; Pijnenborg, Johanna M. A. (Elsevier, 2021)
    Objective Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ...
  • Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth 

    Gómez Vilarrubla, Ariadna; Mas Parés, Berta; Díaz, Marta; Xargay Torrent, Sílvia; Carreras Badosa, Gemma; Jové Font, Mariona; Martin Gari, Meritxell; Bonmatí Santané, Alexandra; Zegher, Francis de; Ibañez, Lourdes; López Bermejo, Abel; Bassols, Judit (Elsevier, 2021)
    Introduction: Fatty acids are essential nutrients for the fetus and are supplied by the mother through the placenta. Desaturase and elongase enzymes play an important role in modulating the fatty acid composition of body ...
  • Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease 

    Gorriz, Jose L.; Arroyo, David; D’Marco, Luis; Torra, Roser; Tomás, Patricia; Puchades, María Jesús; Panizo, Nayara; Pantoja, Jonay; Montomoli, Marco; Llisterri, José Luis; Pallares Carratalá, Vicente; Valdivielso Revilla, José Manuel (BMC, 2021)
    Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence ...
  • Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19 

    Buxeda, Anna; Arias Cabrales, Carlos; Pérez Sáez, María José; Cacho, Judit; Cabello Pelegrin, Sheila; Melilli, Edoardo; Aladrén, María José; Galeano, Cristina; Lorenzo, Inmaculada; Mazuecos, Auxiliadora; Saura, Isabel María; Franco, Antonio; Ruiz Fuentes, María del Carmen; Sánchez Cámara, Luis Alberto; Siverio, Orlando; Martín Conde, María Luisa; González García, Elena; López, Verónica; Martin Moreno, Paloma Leticia; Moina, Iñigo; Moral Berrio, Esperanza; Moreso, Francesc; Portolés, José María; Santana Estupiñán, Raquel; Zárraga, Sofía; Canal, Cristina; Sánchez Álvarez, Emilio; Pascual, Julio; Crespo, Marta (Elsevier, 2021)
    Introduction:Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time torecovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acutekidney injury have ...
  • Substrate-borne vibrational signals in mating communication of Macrolophus bugs 

    Gemeno Marín, César; Baldo, Giordana; Nieri, Rachele; Valls Marsal, Joan; Alomar, Òscar; Mazzoni, Valerio (Springer, 2015-07)
    The mirid bugs Macrolophus pygmaeus and M. costalis use substrate-borne vibrational signals during pair formation and in male-male interactions as determined by laser vibrometry. The vibrational communication of Macrolophus ...
  • Cuticular hydrocarbons discriminate cryptic Macrolophus species (Hemiptera: Miridae) 

    Gemeno Marín, César; Laserna,N.; Riba i Viladot, Magí; Valls Marsal, Joan; Castañé, C.; Alomar, Òscar (Cambridge University Press, 2012-12)
    Macrolophus pygmaeus is commercially employed in the biological control of greenhouse and field vegetable pests. It is morphologically undistinguishable from the cryptic species M. melanotoma, and this interferes with the ...
  • Effects of Acute Psychological and Physiological Stress on Rock Climbers 

    Villavicencio, Pamela; Bravo Navarro, Cristina; Ibarz, Antoni; Solé Cases, Silvia (MDPI, 2021-10-27)
    The aim of this study was to assess the effects that psychological and physiological stressors have on indoor rock climbers, as well as to identify sex differences. Methods: 14 intermediate rock climbers participated in ...
  • Toxicological Evaluations in Macrophages and Mice Acutely and Chronically Exposed to Halloysite Clay Nanotubes Functionalized with Polystyrene 

    Toledano Magaña, Yanis; Flores-Santos, Leticia; Montes de Oca, Georgina; González Montiel, Alfonso; García Ramos, Juan Carlos; Mora Giral, Concepció; Saavedra Ávila, Noemí Alejandra; Gudiño Zayas, Marco; González Ramírez, Luisa Carolina; Laclette, Juan P.; Carrero, Julio C. (American Chemical Society, 2021-10-27)
    Halloysite clay nanotubes (HNTs) have been proposed as highly biocompatible for several biomedical applications. Various polymers have been used to functionalize HNTs, but scarce information exists about polystyrene for ...
  • High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain 

    Dòria, Montserrat; Betriu i Bars, M. Àngels; Belart, Montserrat; Rosado, Verónica; Hernández, Marta; Sarró, Felipe; Real, Jordi; Castelblanco Echavarría, Esmeralda; Pacheco, Linda R.; Fernández i Giráldez, Elvira; Franch-Nadal, Josep; Gratacòs, Mònica; Mauricio Puente, Dídac (MDPI, 2021)
    Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without ...
  • Characterisation of the inflammatory response triggered by topical ingenol mebutate 0.05% gel in basal cell carcinoma 

    García de la Fuente, María Reyes; Santacana Espasa, Maria; Verdaguer Autonell, Joan; Vilardell, Felip; Garí Marsol, Eloi; Casanova i Seuma, Josep M. (Josep Manel) (WileyAustralasian College of Dermatologists, 2020-01-16)
    Background/Objective Ingenol mebutate gel is approved for actinic keratosis field therapy, but little has been published as a treatment of basal cell carcinoma (BCC). Our objective is to characterise the histopathological ...
  • Evaluation of tumor interstitial fluid-extraction methods for proteome analysis: comparison of biopsy elution versus centrifugation 

    Matas Nadal, Clara; Bech Serra, Joan Josep; Guasch Vallés, Marta; Fernández Armenteros, José Manuel; Barceló Gómez, Carla; Casanova i Seuma, Josep M. (Josep Manel); de la Torre Gómez, Carolina; Aguayo Ortiz, Rafael; Garí Marsol, Eloi (American Chemical Society, 2020-01-01)
    The analysis of Tumor Interstitial Fluid (TIF) composition is a valuable procedure to identify anti-metastatic targets, and different laboratories have set up techniques for TIF isolation and proteomic analyses. However, ...
  • The Role of Predictive Biomarkers in Endocervical Adenocarcinoma: Recommendations From the International Society of Gynecological Pathologists 

    Bosse, Tjalling; Lax, Sigurd; Abu-Rustum, Nadeem R.; Matias-Guiu, Xavier (International Society of Gynecological Pathologists, 2021)
    To review the scientific evidence related to predictive biomarkers in cervical adenocarcinoma (ADC). The authors reviewed the literature regarding predictive biomarkers in cervical ADC. There were several limitations: (1) ...
  • Análisis de la deshidratación de adultos mayores en una residencia geriátrica de España: prevalencia y factores asociados 

    Botigué, Teresa; Miranda Iglesias, Jessica; Escobar Bravo, Miguel Ángel; Lavedán, Ana; Roca Llobet, Judith; Masot, Olga (Arán Ediciones, 2021)
    Introducción: la deshidratación en las personas mayores institucionalizadas es un problema poco explorado, no habiéndose encontrado evidencia al respecto en relación con las personas mayores del contexto residencial español. ...
  • An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation in Nuclear Respiratory Factor 1 (Nrf1) Altering the DNA Methylation State and Correct Embryonic Development 

    Sorolla Bardají, Maria Alba; Marqués, Marta; Parisi, Eva; Sorolla Bardají, Anabel (MDPI, 2021)
    We have established a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identify novel genes playing a role in epigenetic regulation in mammals. We hypothesize that the ENU mutagenesis screen will lead to the ...
  • Mediterranean Diet and Healthy Eating in Subjects with Prediabetes from the Mollerussa Prospective Observational Cohort Study 

    Falguera, Mireia; Catelblanco, Esmeralda; Rojo-López, Marina Idalia; Vilanova, María-Belén; Real, Jordi; Alcubierre Calvo, Núria; Miró, Neus; Molló Inesta, Àngels; Mata Cases, Manel; Franch-Nadal, Josep; Granado Casas, Minerva; Mauricio Puente, Dídac (MDPI, 2021)
    We aimed to assess differences in dietary patterns (i.e., Mediterranean diet and healthy eating indexes) between participants with prediabetes and those with normal glucose tolerance. Secondarily, we analyzed factors related ...
  • Preliminary Results of a Screening Programme for Chlamydia in an Asymptomatic Young Population in Spain 

    Yuguero Torres, Oriol; Fernández Armenteros, José Manuel; Vilela, Álvaro; Aramburu, Jesus; Laín, Raquel; Godoy i García, Pere (Frontiers Media, 2021)
    Introduction: Chlamydia trachomatis (CT) infection has increased in recent years, reaching 127 million cases in 2016. Possible complications, especially among women, require intervention for early detection of the ...
  • Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation 

    Eritja Sánchez, Núria; Navaridas Fernández de Bobadilla, Raúl; Ruiz Mitjana,Anna; Vidal Sabanés, Maria; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (MDPI, 2021-10-05)
    TGF-β has a dichotomous function, acting as tumor suppressor in premalignant cells but as a tumor promoter for cancerous cells. These contradictory functions of TGF-β are caused by different cellular contexts, including ...
  • Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea 

    Cambras, Trinitat; Romero, Odile; Díez Noguera, Antoni; Lecube Torelló, Albert; Sampol, Gabriel (MDPI, 2021)
    Sleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic ...
  • LINCE PLUS software for systematic observational studies in sports and health 

    Soto Fernández, Alberto; Camerino Foguet, Oleguer; Iglesias, Xavier; Anguera, M. Teresa; Castañer Balcells, Marta (Springer, 2021)
    This paper aims to offer a free software program, LINCE PLUS, suitable for systematic observational studies in sports and health, conducted in natural contexts such as training, education or psychology. Using one or several ...
  • PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia 

    Rodríguez-Pascau, Laura; Britti, Elena; Calap Quintana, Pablo; Na Dong, Yi; Vergara, Cristina; Delaspre, Fabien; Medina Carbonero, Marta; Tamarit Sumalla, Jordi; Pallardó, Federico V.; Gonzalez Cabo, Pilar; Ros, Joaquim; Lynch, David R.; Martinell, Marc; Pizcueta, Pilar (Elsevier, 2021)
    Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The ...

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