Institut de Recerca Biomèdica de Lleida (IRBLleida)
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L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].
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Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project
(BioMed Central, 2019-11-15)BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the ... -
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms
(Public Library of Science, 2019-10-04)Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ... -
Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women
(Nature Publishing Group, 2019-11-05)Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ... -
Dissimilar impact of Mediterranean diet and physical activity on estimated body composition: A cross-sectional study from the ILERVAS project
(MDPI, 2019-06-17)There is a close relationship between lifestyle behaviors and excess adiposity. Althoughbody mass index (BMI) is the most used approach to estimate excess weight, other anthropometricindices have been developed to ... -
Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis
(Nature Publishing Group, 2019-08-05)Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The ... -
Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia
(BMJ, 2020-01-07)Objectives: To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to ... -
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus
(Elsevier, 2017)Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best ... -
The Mediterranean Diet is Associated with an Improved Quality of Life in Adults with Type 1 Diabetes
(MDPI, 2020-01-02)This study aimed to assess the potential association between dietary patterns (i.e., the Mediterranean Diet (MedDiet) and healthy eating) and patient-reported quality of life (QoL) and treatment satisfaction (TS) in adults ... -
Glial activation and central synapse loss, but not motoneuron degeneration, are prevented by the sigma-1 receptor agonist PRE-084 in the Smn2B/- mouse model of spinal muscular atrophy
(American Association of Neuropathologists, 2018)Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with concomitant muscle denervation. MN excitability and vulnerability to disease are particularly regulated by cholinergic synaptic afferents ... -
Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair
(Federation of American Societies for Experimental Biology, 2019)C-type synaptic boutons (C-boutons) provide cholinergic afferent input to spinal cord motor neurons (MNs), which display an endoplasmic reticulum (ER)–related subsurface cistern (SSC) adjacent to their postsynaptic membrane. ... -
A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma
(BMC (part of Springer Nature), 2019-05-22)Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ... -
Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects
(MDPI, 2019-05)The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 ... -
Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity
(Elsevier, 2019-06)Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. ... -
Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study
(Springer Verlag, 2019-05)X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ... -
Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential
(Wiley online library, 2019-05)Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in ... -
Impact of sleep health on self-perceived health status
(Nature Publishing Group, 2019-05)Although sleep habits have long been recognized as a promoter of health, the World Health Organization 2014 report on non-communicable diseases (NCDs) only listed smoking, alcohol intake, diet and physical activity (PA) ... -
Identification and validation of circulating miRNAs as endogenous controls in obstructive sleep apnea
(Public Library of Science, 2019-03-13)microRNAs (miRNAs) are non-coding RNAs highly relevant as biomarkers for disease. A seminal study that explored the role of miRNAs in obstructive sleep apnea syndrome (OSA) demonstrated their usefulness in clinical management. ... -
Migrated t lymphocytes into malignant pleural effusions: an indicator of good prognosis in lung adenocarcinoma patients
(Nature Publishing Group, 2019)The presence of leukocyte subpopulations in malignant pleural effusions (MPEs) can have a different impact on tumor cell proliferation and vascular leakiness, their analysis can help to understand the metastatic microenvironment. ... -
Empathy and big five personality model inmedical students and its relationship togender and specialty preference: a cross-sectional study
(BioMed Central, 2019)Background:Given the influence that personality can have on empathy, this study explores the relationshipbetween empathy and personality, using three different measures of empathy, and taking into account gender andspecialty ... -
Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
(Nature Publishing Group, 2019-08-22)Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium ...