Llibres / Capítols de llibre (Ciències Mèdiques Bàsiques)

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    Signalling Oxidative Stress in Saccharomyces cerevisiae
    (IntechOpen, 2012) Torre Ruiz, M. A. de la; Serrano Endolz, Luis; Petkova, Mima Ivanova; Pujol Carrión, Núria
    Oxidative stress occurs in the natural environment with exposure to aerobic conditions and UV light. Reactive oxygen species (ROS) are also the consequence of normal cellular metabolism. Aerobic organisms sense redox perturbations and develop several different adaptive mechanisms in order to acquire survival capacity (Zheng & Storz, 2000). The mitochondrial respiratory chain is the major ROS source of reactive oxygen species. ROS can damage a wide range of molecules, including nucleic acids, proteins and lipids. The accumulation of oxidised proteins, DNA damage and the increased production of ROS, concomitant with a depletion of antioxidant defences, seem to be key factors in aging and cell death.
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    BP-EVs: A Novel Source of EVs in the Nanocarrier Field
    (IntechOpen, 2023) Lorca, Cristina; Fernández-Rhodes, María; Sánchez Milán, José Antonio; Mulet, Maria; Lisa, Julia; Gallart Palau, Xavier Ramon; Serra, Aida
    Extracellular vesicles (EVs) represent a complex mechanism of molecular exchange that has garnered significant attention in recent times. Nonetheless, identifying sustainable sources of biologically safe EVs remains challenging. This chapter delves into the utilization of fermented food industry by-products as a circular and secure reservoir of biocompatible EVs, dubbed as BP-EVs. BP-EVs demonstrate excellent oral bioavailability and biodistribution, with negligible cytotoxicity, and a preferential targeting capacity toward the central nervous system, liver, and skeletal tissues. The ease of editing BP-EVs is also depicted using the most common EV editing methods in this chapter. Globally, these groundbreaking findings are poised to unlock significant avenues for leveraging BP-EVs as an optimal source of biocompatible nanovesicles across a wide array of applications within the bioeconomy and biomedical fields. These applications primarily target molecule delivery into the central nervous system and skeletal tissue but are not limited to these two organism systems.