Recent Submissions

  • Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective 

    Bauer, Kylynda C.; Littlejohn, Paula T.; Ayala Jové, Ma. Victoria (Maria Victoria); Creus Cuadros, Anna; Finlay, Barton Brett (AGA InstituteElsevier, 2022)
    Nonalcoholic fatty liver disease (NAFLD) is a chronic con dition affecting one quarter of the global population. Although primarily linked to obesity and metabolic syn drome, undernutrition and the altered (dysbiotic) gut ...
  • The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology 

    Jové Font, Mariona; Mota Martorell, Natàlia; Torres Cabestany, Pascual; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (MDPI, 2021)
    Current shreds of evidence point to the entorhinal cortex (EC) as the origin of the Alzheimer’s disease (AD) pathology in the cerebrum. Compared with other cortical areas, the neurons from this brain region possess an ...
  • Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment 

    Rossi, Chiara; Fernàndez, Anna; Torres Cabestany, Pascual; Ramírez Núñez, Omar; Granado-Serrano, Ana Belén; Fontdevila, Laia; Povedano, Mònica; Pamplona Gras, Reinald; Ferrer, Isidre; Portero Otín, Manuel (MDPI, 2021)
    Previous evidence links the formation of extranuclear inclusions of transcription factors, such as ERK, Jun, TDP-43, and REST, with oxidative, endoplasmic-reticulum, proteasomal, and osmotic stress. To further characterize ...
  • Redox proteomic profiling of neuroketal-adducted proteins in human brain: regional vulnerability at middle age increases in the elderly 

    Domínguez, Mayelín; de Oliveira, Eliandre; Odena, María Antonia; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (2016)
    Protein lipoxidation was assessed in the parietal cortex (PC), frontal cortex (FC), and cingulate gyrus (CG) in middle-aged and old-aged individuals with no clinical manifestations of cognitive impairment, in order to ...
  • Molecular and structural antioxidant defenses against oxidative stressin animals 

    Pamplona Gras, Reinald; Costantini, David (American Physiological Society, 2011)
    In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural ...
  • Proteins in human brain cortex are modified by oxidation, glycoxidation and lipoxidation: effects of Alzheimer's disease and identification of lipoxidation targets. 

    Pamplona Gras, Reinald; Dalfó, Esther; Ayala Jové, Ma. Victoria (Maria Victoria); Bellmunt, Maria Josep; Prat Corominas, Joan; Ferrer, Isidre; Portero Otín, Manuel (American Society for Biochemistry and Molecular BiologyElsevier, 2005)
    Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the amount of structurally characterized probes ...
  • Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals 

    Pamplona Gras, Reinald; Portero Otín, Manuel; Riba, David; Ruiz, Cristina; Prat Corominas, Joan; Bellmunt, Maria Josep; Barja, Gustavo (Elsevier, 1998)
    The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. ...
  • Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness 

    Cambray Carner, Serafí; Ibarz Escuer, Mercedes; Bermúdez López, Marcelino; Marti Antonio, Manuel; Bozić Stanojević, Milica; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (MDPI, 2020)
    Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with ...
  • Precise Mapping of Otp Expressing Cells Across Different Pallial Regions Throughout Ontogenesis Using Otp-Specific Reporter Transgenic Mice 

    Morales, Lorena; González Alonso, Alba; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media, 2022)
    Taking advantage of two Otp-specific reporter lines of transgenic mice (Otp-eGFP and Otp-Cre; Rpl22-HA), we identify and describe different Otp cell populations across various pallial regions, including the pallial amygdala, ...
  • Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study 

    Sánchez Peña, Enric; Kerkeni, M.; Hernández García, Marta; Gavaldá, Ricard; Rius, Ferran; Sauret, Ariadna; Torres, Gerard; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Castro-Boqué, Eva; Purroy Garcia, Francisco; Mauricio Puente, Dídac; Farràs-Sallés, Cristina; Buti, Miquel; Godoy i García, Pere; Pamplona Gras, Reinald; Lecube Torelló, Albert (MDPI, 2022)
    A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation ...
  • Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia 

    Granado-Serrano, Ana Belén; Martín Garí, Meritxell; Sánchez, Virginia; Riart Solans, Marissa; Lafarga Giribets, Antonia; Berdún Hernández, Rebeca; Vilaprinyo Terré, Ester; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (MDPI, 2022)
    This study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that included three different ...
  • Elovl2-Ablation Leads to Mitochondrial Membrane Fatty Acid Remodeling and Reduced Efficiency in Mouse Liver Mitochondria 

    Gómez Rodríguez, Alexia; Talamonti, Emanuela; Naudí i Farré, Alba; Kalinovich, Anastasia V.; Pauter, Anna M.; Barja, Gustavo; Bengtsson, Tore; Jacobsson, Anders; Pamplona Gras, Reinald; Shabalina, Irina G. (MDPI, 2022)
    The fatty acid elongase elongation of very long-chain fatty acids protein 2 (ELOVL2)controls the elongation of polyunsaturated fatty acids (PUFA) producing precursors for omega-3,docosahexaenoic acid (DHA), and omega-6, ...
  • Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling 

    Visa Pretel, Anna; Alza, Lía; Cantí Nicolás, Carles; Herreros Danés, Judit (Elsevier, 2022-04-04)
    Mibefradil and NNC-55-0396, tetralol derivatives with a proven ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth ...
  • Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study 

    de Rojas, Itziar; Hernández, Isabel; Montrreal, Laura; Quintela, Inés; Calero, Miguel; Royo, Jose Luís; Huerto Vilas, Raquel; González Pérez, Antonio; Franco Macías, Emilio; Macías, Juan; Menéndez González, Manuel; Frank García, Ana; Diez Fairen, Mónica; Lage, Carmen; García Madrona, Sebastián; Aguilera, Nuria; García González, Pablo; Puerta, Raquel; Sotolongo Grau, Oscar; Alonso Lana, Silvia; Rábano, Alberto; Arias Pastor, Alfonso; Pastor, Ana Belén; Corma Gómez, Anaïs; Martín Montes, Ángel; Martínez Rodríguez, Carmen; Buiza Rueda, Dolores; Rodríguez Rodríguez, Eloy; Álvarez, Ignacio; Rosas Allende, Irene; Pineda, Juan A.; Bernal Sánchez-Arjona, María; Fernández Fuertes, Marta; Mendoza, Silvia; Del Ser, Teodoro; García Ribas, Guillermo; Sánchez Juan, Pascual; Pastor, Pau; Bullido, María J.; Álvarez, Victoria; Real, Luis M; Mir, Pablo; Piñol Ripoll, Gerard; García Alberca, Jose María; Medina, Miguel; Orellana, Adelina; Butler, Chris R.; Marquié, Marta; Sáez, María Eugenia; Carracedo, Angel; Tárraga, Lluís; Boada, Mercè; Ruiz, Agustín (MDPI, 2021)
    Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study ...
  • Gut microbes shape microglia and cognitive function during malnutrition 

    Bauer, Kylynda C.; York, Elisa M.; Cirstea, Mihai; Radisavljevic, Nina; Petersen, Charisse; Huus, Kelsey E.; Brown, Eric M.; Bozorgmehr, Tahereh; Berdún Hernández, Rebeca; Bernier, Louis-Philippe; Lee, Amy H.Y.; Woodward, Sarah E.; Krekhno, Zakhar; Han, Jun; Hancock, Robert E.W.; Ayala Jové, Ma. Victoria (Maria Victoria); MacVicar, Brian A.; Finlay, Barton Brett (Wiley Periodicals, 2022)
    Fecal-oral contamination promotes malnutrition pathology. Lasting consequences of early life malnutrition include cognitive impairment, but the underlying pathology and influence of gut microbes remain largely unknown. ...
  • Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease 

    Castelblanco Echavarría, Esmeralda; Sarrias, Maria-Rosa; Betriu i Bars, M. Àngels; Soldevila, Berta; Barranco Altirriba, María; Franch-Nadal, Josep; Valdivielso Revilla, José Manuel; Bermúdez López, Marcelino; Groop, Per-Henrik; Fernández i Giráldez, Elvira; Alonso, Núria; Mauricio Puente, Dídac (Impact Journals, 2021)
    This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD. We evaluated the association of CD5L and sCD36 with a ...
  • Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients 

    Bermúdez López, Marcelino; Perpiñán, Hèctor; Amigó, Núria; Castro-Boqué, Eva; Alonso, Núria; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (European Renal Association - European Dialysis and Transplant Association (ERA-EDTA)Oxford University Press, 2021)
    Background: Chronic kidney disease (CKD) patients have a high burden of atheromatous cardiovascular disease (ASCVD) not fully explained by traditional lipid parameters. Lipoprotein composition and subclass particle number ...
  • ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma 

    Megino-Luque, Cristina; Sisó, Pol; Mota Martorell, Natàlia; Navaridas Fernández de Bobadilla, Raúl; de la Rosa, Inés; Urdanibia, Izaskun; Albertí Valls, Manel; Santacana Espasa, Maria; Pinyol, Miquel; Bonifaci, Núria; Macià Armengol, Anna; Llobet Navàs, David; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Eritja Sánchez, Núria (Federation of European Biochemical SocietiesJohn Wiley & Sons, 2022)
    AT-rich interactive domain-containing protein 1A (ARID1A) loss-of-function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms ...
  • Differential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classification 

    Moreno, Sara; Maiques Carlos, Oscar; Barceló Gómez, Carla; Romero, Marta; Santacana Espasa, Maria; Gómez, Ignacio; Cuevas Sánchez, Dolors; Velasco Sánchez, Ana; Veà Jódar, Àlvar; Macià Armengol, Anna; Boix, Ramon; Valls Marsal, Joan; Gatius Calderó, Sònia; Cantí Nicolás, Carles; Matias-Guiu, Xavier; Soria, Xavier; Martí Laborda, Rosa Ma. (Society for Publication of Acta Dermato-Venereologica, 2021)
    BRAF/V600E mutation and other cell growth/growth-control mechanisms are involved in naevogenesis and melanomagenesis. Immunoexpression of BRAF/V600E and other molecules (p16, phosphatase and tensin homologue (PTEN), Ki67, ...
  • PEG-Interferon-α ribavirin-induced HCV viral clearance: a pharmacogenetic multicenter Spanish study 

    Milara, Javier; Outeda Macias, María; Aumente Rubio, Mª Dolores; Más Serrano, Patricio; Aldaz, Azucena; Calvo, Mª Victoria; García Simón, Mª Sergia; Martín Barbero, Marisa; SEFH-PkGen research group (Sociedad Española de Farmacia Hospitalaria, 2015)
    Objective: Dual PEGylated interferon-α (PEG-IFN) and ribavirin therapy has been the main hepatitis C virus (HCV) treatment of the last decade. Current direct-acting antiviral agents have improved the outcome of therapy but ...

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