Articles publicats (Medicina Experimental)
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L'origen de l'home: Darwin i la psicologia
(Institut d'Estudis Catalans, 2021-09-13)The purpose of this article is to review the psychological evidence presented by Darwin in The Origin of Man and Selection in Relation to Sex, as well as the complex reciprocal relationships between evolutionism and ... -
Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity
(Springer, 2020-08-01)Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ... -
Up-Regulation of Specific Bioactive Lipids in Celiac Disease
(MDPI, 2021)Celiac disease (CD) is an autoimmune enteropathy linked to alterations of metabolism. Currently, limited untargeted metabolomic studies evaluating differences in the plasma metabolome of CD subjects have been documented. ... -
Spinal Muscular Atrophy autophagy profle is tissue-dependent: diferential regulation between muscle and motoneurons
(BioMed Central, 2021)Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and defcient levels cause spinal cord motoneurons (MNs) degeneration and muscle atrophy. ... -
Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype
(Nature Research, 2021)Senescent cells are capable of expressing a myriad of infammatory cytokines and this proinfammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ... -
Metabolic risk management, physical exercise and lifestyle counselling in low-active adults: controlled randomized trial (BELLUGAT)
(BMC, 2017)Background: The primary aim of this study is to evaluate the effectiveness of different doses (intensity) of supervised exercise training — concomitant with lifestyle counselling — as a primary care intervention tool for ... -
Papel del frijol negro Phaseolus vulgaris en el estado nutricional de la población guatemalteca
(Sociedad Latinoamericana de Nutrición, 2004)En Guatemala existe un fenómeno de superposición epidemiológica, en el que coexisten problemas de salud propios de países desarrollados con otros característicos de poblaciones en vías de desarrollo. Se observan ... -
In vitro cell migration, invasion, and adhesion assays: from cell imaging to data analysis
(Frontiers Media, 2019-06)Cell migration is a key procedure involved in many biological processes includingembryological development, tissue formation, immune defense or inflammation, andcancer progression. How physical, chemical, and molecularaspects ... -
Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study
(Public Library of Science, 2021)Background COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging. Objective To describe the rate of TEE ... -
Regulation of membrane unsaturation as antioxidant adaptive mechanism in long-lived animal species
(Phcog.Net, 2011)Oxidative stress resulting from biomolecular oxidative damage due to the imbalance between reactive species production and antioxidant response has become an universal constraint of life-history evolution in animals and ... -
Target of rapamycin activation predicts lifespan in fruit flies
(Taylor & Francis, 2015-09)Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or ... -
Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment
(Wiley, 2020-12)Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ... -
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
(BMJ Publishing GroupBritish Society of Gastroenterology, 2021-01)Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We ... -
Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort
(MDPI, 2021-03-23)Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. ... -
Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons
(Elsevier, 2021-04-13)Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder caused by loss of the Survival Motor Neuron 1 gene (SMN1). Due to this depletion of the survival motor neuron (SMN) protein, the disease is characterized by ... -
In vivo diabetogenic action of CD41+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18
(Wiley, 2011)CD4+ T lymphocytes are required to induce spontaneous autoimmune diabetes in the NOD (Non Obese Diabetic) mouse. Since pancreatic β cells upregulate Fas expression upon exposure to proinflammatory cytokines, we studied ... -
Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice
(Wiley, 2013)The cholera toxin B subunit (CTB) has been used as adjuvant to improve oral vaccine delivery in type 1 diabetes. The effect of CTB/peptide formulations on Ag-specific CD4+ T cells has remained largely unexplored. Here, ... -
High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition
(MDPI, 2021-02-03)Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed ... -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
(Taylor & Francis, 2021-02-08)In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ...