The effect of external stimulation on functional networks in the aging healthy human brain

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dc.contributor.authorEscrichs, Anira
dc.contributor.authorSanz Perl, Yonatan
dc.contributor.authorMartínez-Molina, Noelia
dc.contributor.authorBiarnés, Carles
dc.contributor.authorGarre Olmo, Josep
dc.contributor.authorFernández Real, José Manuel
dc.contributor.authorRamos, Rafel
dc.contributor.authorMartí, Ruth
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorBrugada, Ramon
dc.contributor.authorSerena, Joaquín
dc.contributor.authorRamió Torrentà, Lluís
dc.contributor.authorColl-De-Tuero, Gabriel
dc.contributor.authorGallart, Luís
dc.contributor.authorBarretina Ginesta, Jordi
dc.contributor.authorVilanova, Joan Carles
dc.contributor.authorMayneris Perxachs, Jordi
dc.contributor.authorSaba, Luca
dc.contributor.authorPedraza, Salvador
dc.contributor.authorKringelbach, Morten L.
dc.contributor.authorPuig, Josep
dc.contributor.authorDeco, Gustavo
dc.date.accessioned2023-11-14T13:03:35Z
dc.date.available2023-11-14T13:03:35Z
dc.date.issued2023
dc.description.abstractUnderstanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, <65 years) and older adults (N =310, ≥ 65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics.
dc.description.sponsorshipAE, YS and GD were supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship.
dc.identifier.doihttps://doi.org/10.1093/cercor/bhac064
dc.identifier.idgrec034180
dc.identifier.issn1460-2199
dc.identifier.urihttps://repositori.udl.cat/handle/10459.1/464515
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.isformatofVersió preprint del document publicat a https://doi.org/10.1093/cercor/bhac064
dc.relation.ispartofCerebral Cortex, 2023, vol. 33, núm. 1, p. 235-245
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/945539/EU/HBP SGA3
dc.rights(c) Oxford University Press, 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectAging
dc.subjectComputational modeling
dc.subjectResting-state fMRI
dc.subjectBrain states
dc.subjectIn silico perturbations
dc.titleThe effect of external stimulation on functional networks in the aging healthy human brain
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/submittedVersion
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