Maternal nutrient restriction in early pregnancy increases the risk of late embryo loss despite no effects on peri-implantation interferon-stimulated genes in suckler beef cattle

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dc.contributor.authorSerrano, Beatriz
dc.contributor.authorMolina Ureste, Ester
dc.contributor.authorNoya, Agustí
dc.contributor.authorLópez-Helguera, Irene
dc.contributor.authorCasasús Pueyo, Isabel
dc.contributor.authorSanz Pascua, Albina
dc.contributor.authorVillalba Mata, Daniel
dc.date.accessioned2020-05-12T16:04:17Z
dc.date.available2020-10-31T23:24:54Z
dc.date.issued2019-10-31
dc.date.updated2020-05-12T16:04:17Z
dc.description.abstractReducing feeding costs in suckler beef herds to improve economic returns could have detrimental impacts on fertility. This study sought to determine whether maternal nutrient restriction during early pregnancy affects interferon-stimulated gene (ISG) expression in peripheral blood mononuclear cells during the peri-implantation period in two beef cattle breeds. Relationships were also examined between subnutrition and pregnancy failure defined according to ISG fold changes on Days 18 and 21 and to plasma pregnancy specific protein B (PSPB) concentrations on Day 28 post-artificial insemination (AI). Pirenaica or Parda de Montaña dams were assigned to a control (n = 23) or subnutrition (n = 30) group, receiving 100% or 65% of their estimated nutritional requirements from Day 1 to 82 post-AI, respectively. Treatment did not affect ISG expression or fertility. According to ISG fold changes (chi-square P = .023) or PSPB levels (chi-square P = .04) recorded in the subnutrition group, late embryo loss was more likely than in controls. Positive correlation was detected between Day 28 PSPB concentrations and both Day 18 MX1, MX2 and ISG15 expression, and Day 21 OAS1 expression. OAS1 and MX1 fold changes were found to be the best variables to discriminate pregnancy status. Our findings indicate that maternal nutrient restriction during the first third of pregnancy does not impair embryo signalling yet may increase the risk of pregnancy failure.
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy and Business and the European Union Regional Development Funds (INIA RTA 2013-00059-C02-01/02, Grant Research Group Funds of the Government of Aragon (A14_17R) and INIA RZP 2015-001). A. Noya received a PhD grant from INIA-Government of Aragon.
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.rvsc.2019.10.023
dc.identifier.idgrec029274
dc.identifier.issn0034-5288
dc.identifier.urihttp://hdl.handle.net/10459.1/68792
dc.language.isoeng
dc.publisherElsevier
dc.publisherAssociation for Veterinary Teaching and Research Work
dc.relationinfo:eu-repo/grantAgreement/MINECO//RTA2013-00059-C02-01/ES/Efectos de la alimentación materna sobre el desarrollo embrionario y la descendencia: implicaciones en la eficiencia productiva de la vaca nodriza/
dc.relationinfo:eu-repo/grantAgreement/MINECO//RZP2015-001/ES/
dc.relationinfo:eu-repo/grantAgreement/MINECO//RTA2013-00059-C02-02/ES/Efectos de la alimentación materna sobre el desarrollo embrionario y la descendencia: implicaciones en la eficiencia productiva de la vaca nodriza/
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.rvsc.2019.10.023
dc.relation.ispartofResearch in Veterinary Science, 2020, vol. 128, p. 69-75
dc.rightscc-by-nc-nd (c) Association for Veterinary Teaching and Research Work, 2019
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.subjectBeef cattle
dc.subjectInterferon tau
dc.subjectUndernutrition
dc.subjectPregnancy loss
dc.titleMaternal nutrient restriction in early pregnancy increases the risk of late embryo loss despite no effects on peri-implantation interferon-stimulated genes in suckler beef cattle
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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