Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study

dc.contributor.authorMacià i Puig, Ma Alba
dc.contributor.authorRomero Fabregat, Mª Paz
dc.contributor.authorYuste, Silvia
dc.contributor.authorLudwig, Iziar A.
dc.contributor.authorPedret, Anna
dc.contributor.authorValls, Rosa Maria
dc.contributor.authorSalamanca, Patricia
dc.contributor.authorSolà, Rosa
dc.contributor.authorMotilva Casado, Mª José
dc.contributor.authorRubió Piqué, Laura
dc.date.accessioned2022-04-05T11:01:22Z
dc.date.available2022-04-05T11:01:22Z
dc.date.issued2022
dc.description.abstractThe present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-week) interventions were combined in a randomized, controlled and parallel study with 121 hypercholesterolemic subjects. Another arm consuming ACN-rich infusion from aronia fruit (ARO) provided matched content and profile of ACN. Plasma, urine and faeces samples were analyzed using UPLC-MS/MS. Results showed higher bioavailability of ACN after ARO compared to RFA, showing a clear apple matrix effect. The dihydrochalcone phloretin-2′-O-glucuronide was the most discriminant intake biomarker of both apples. The urinary peonidin-3-O-galactoside was a good biomarker after both ARO and RFA intakes, whereas peonidin-O-arabinoside was reported to be specific from ARO. The elucidation of the phenolic metabolism and the selection of intake biomarkers is a promising approach to relate phenolic compounds and human healthca_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Industry, Economy and Competitiveness through the AGL2016-76943-C2-1-R and AGL2016-76943-C2-2-R projects (co-funded by the European Social Fund, European Union); M.J. Motilva thanks to Consejo Superior de Investigaciones Científicas-CSIC for partial funding throught the “Ayudas incorporación a escalas científicas CSIC, 2018” (Reference 201870I129). L.R. was Sara Borrell postdoctoral contract and she is a Serra Húnter Fellow. I.A.L. enjoys a post-doctoral contract (2017PMF-POST2-19) from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV). S.Y. was supported by a pre-doctoral grant from the University of Lleida.ca_ES
dc.identifier.doihttps://doi.org/10.1016/j.foodchem.2022.132612
dc.identifier.idgrec032985
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10459.1/73521
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76943-C2-1-R/ES/ca_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76943-C2-2-R/ES/ca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.foodchem.2022.132612ca_ES
dc.relation.ispartofFood Chemistry, 2022, vol. 384, núm. 1, p. 1-12ca_ES
dc.rightscc by-nc-nd (c) Macià et al., 2022ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnthocyaninsca_ES
dc.subjectIntake biomarkersca_ES
dc.subjectMetabolismca_ES
dc.subjectRed-fleshed appleca_ES
dc.subjectUPLC-MS/MSca_ES
dc.subject.otherPomesca_ES
dc.subject.otherMetabolismeca_ES
dc.titlePhenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR studyca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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