Molecular and structural antioxidant defenses against oxidative stressin animals

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dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorCostantini, David
dc.date.accessioned2022-05-16T12:26:37Z
dc.date.available2022-05-16T12:26:37Z
dc.date.issued2011
dc.description.abstractIn this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural and functional factors affecting the "whole" organism, 3) to incorporate, when supportable by evidence, mechanisms into models of life-history trade-offs and maternal/epigenetic inheritance, 4) to highlight the importance of studying the biochemical integration of redox systems, and 5) to discuss the link between maximum life span and antioxidant defenses. The traditional concept of antioxidant defenses emphasizes the importance of the chemical nature of molecules with antioxidant properties. Research in the past 20 years shows that animals have also evolved a high diversity in structural defenses that should be incorporated in research on antioxidant responses to reactive species. Although there is a high diversity in antioxidant defenses, many of them are evolutionary conserved across animal taxa. In particular, enzymatic defenses and heat shock response mediated by proteins show a low degree of variation. Importantly, activation of an antioxidant response may be also energetically and nutrient demanding. So knowledge of antioxidant mechanisms could allow us to identify and to quantify any underlying costs, which can help explain life-history trade-offs. Moreover, the study of inheritance mechanisms of antioxidant mechanisms has clear potential to evaluate the contribution of epigenetic mechanisms to stress response phenotype variation.ca_ES
dc.description.sponsorshipDuring manuscript preparation, Reinald Pamplona was supported, in part,by I+D grants from the Spanish Ministry of Science and Innovation(BFU2009-11879/BFI), and the Generalitat of Catalonia (2009SGR735); Da-vid Costantini was supported by a postdoctoral NERC research fellowship(NE/G013888/1)
dc.identifier.doihttps://doi.org/10.1152/ajpregu.00034.2011
dc.identifier.idgrec017862
dc.identifier.issn0363-6119
dc.identifier.issn1522-1490
dc.identifier.urihttp://hdl.handle.net/10459.1/83299
dc.language.isoengca_ES
dc.publisherAmerican Physiological Societyca_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN//BFU2009-11879/ES/Efecto Del Envejecimiento Y De La Restriccion De Metionina Sobre La Vulnerabilidad Neuronal Al Estres Oxidativo En Diferentes Regiones Del Sistema Nervioso Central/
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1152/ajpregu.00034.2011ca_ES
dc.relation.ispartofAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2011, vol. 301, núm. 4, p. R843-R863ca_ES
dc.rights(c) American Physiological Society, 2011ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.subjectAntioxidant Defencesca_ES
dc.subjectFree Radicalsca_ES
dc.subjectMaximum Life Spanca_ES
dc.subjectMitochondriaca_ES
dc.subjectMolecular Evolutionca_ES
dc.subjectOxidative Damageca_ES
dc.subjectRedox Reactionsca_ES
dc.subjectRedox Signalingca_ES
dc.titleMolecular and structural antioxidant defenses against oxidative stressin animalsca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionca_ES
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