Evaluation of plasma-free endocannabinoids and their congeners in abstinent cocaine addicts seeking outpatient treatment: impact of psychiatric co-morbidity

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dc.contributor.authorPavón, Francisco Javier
dc.contributor.authorAraos, Pedro
dc.contributor.authorPastor, Antoni
dc.contributor.authorCalado, Montserrat
dc.contributor.authorPedraz, María
dc.contributor.authorCampos Cloute, Rafael
dc.contributor.authorRuiz, Juan Jesús
dc.contributor.authorSerrano, Antonia
dc.contributor.authorBlanco Calvo, Eduardo
dc.contributor.authorRivera, Patricia
dc.contributor.authorSuárez, Juan
dc.contributor.authorRomero-Cuevas, Miguel
dc.contributor.authorPujadas, Mitona
dc.contributor.authorVergara-Moragues, Esperanza
dc.contributor.authorGornemann, Isolde
dc.contributor.authorTorrens, Marta
dc.contributor.authorDe la Torre, Rafael
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.date.accessioned2015-02-12T14:33:27Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2013-11-14
dc.date.updated2015-02-12T14:33:27Z
dc.description.abstractCocaine is associated with serious health problems including psychiatric co-morbidity. There is a need for the identification of biomarkers for the stratification of cocaine-addicted subjects. Several studies have evaluated circulating endocannabinoid-related lipids as biomarkers of inflammatory, metabolic and mental disorders. However, little is known in substance use disorders. This study characterizes both free N-acyl-ethanolamines (NAEs) and 2-acyl-glycerols in abstinent cocaine addicts from outpatient treatment programs who were diagnosed with cocaine use disorder (CUD; n=88), and age-/gender-/body mass-matched healthy control volunteers (n=46). Substance and mental disorders that commonly occur with substance abuse were assessed by the semi-structured interview Psychiatric Research Interview for Substance and Mental Diseases' according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision' (DSM-IV-TR) and plasma-free acyl derivatives were quantified by a liquid chromatography-tandem mass spectrometry system. The results indicate that plasma acyl derivatives are altered in abstinent cocaine-addicted subjects with CUD (CUD subjects). While NAEs were found to be increased, 2-acyl-glycerols were decreased in CUD subjects compared with controls. Multivariate predictive models based on these lipids as explanatory variables were developed to distinguish CUD subjects from controls providing high discriminatory power. However, these alterations were not influenced by the DSM-IV-TR criteria for cocaine abuse and dependence as cocaine trait severity measure. In contrast, we observed that some free acyl derivatives in CUD subjects were found to be affected by the diagnosis of some co-morbid psychiatric disorders. Thus, we found that the monounsaturated NAEs were significantly elevated in CUD subjects diagnosed with mood [N-oleoyl-ethanolamine and N-palmitoleoyl-ethanolamine (POEA)] and anxiety (POEA) disorders compared with non-co-morbid CUD subjects. Interestingly, the coexistence of alcohol use disorders did not influence the circulating levels of these free acyl derivatives. In summary, we have identified plasma-free acyl derivatives that might serve as reliable biomarkers for CUD. Furthermore, we found that monounsaturated NAE levels are also enhanced by co-morbid mood and anxiety disorders in cocaine addicts. These findings open the way for the development of new strategies for cocaine addiction diagnosis and treatment.
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/adb.12107
dc.identifier.idgrec020235
dc.identifier.issn1355-6215
dc.identifier.urihttp://hdl.handle.net/10459.1/47961
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.isformatofReproducció del document publicat a : https://doi.org/10.1111/adb.12107
dc.relation.ispartofAddiction Biology, 2013, vol. 18, num. 6, p. 955-969
dc.rights(c) John Wiley & Sons, 2013
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAbuse
dc.subjectCocaine
dc.subjectDependence
dc.subjectDSM-IV-TR
dc.subjectEndocannabinoid
dc.subjectPsychiatric co-morbidity
dc.subject.classificationCocaïna
dc.subject.otherCocaine
dc.titleEvaluation of plasma-free endocannabinoids and their congeners in abstinent cocaine addicts seeking outpatient treatment: impact of psychiatric co-morbidity
dc.typeinfo:eu-repo/semantics/article
dc.type.versionPublishedVersion
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