A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia
| dc.contributor.author | Faith Oyelere, Sunday | |
| dc.contributor.author | Hezekiah Ajayi, Oluwatobi | |
| dc.contributor.author | Eunice Ayoade, Titilayo | |
| dc.contributor.author | Santana Pereira, George | |
| dc.contributor.author | Dayo Owoyemi, Bolaji Charles | |
| dc.contributor.author | Olaoluwa Ilesanmi, Ajibola | |
| dc.contributor.author | Amos Akinyemi, Olalekan | |
| dc.date.accessioned | 2022-12-17T08:47:42Z | |
| dc.date.available | 2022-12-17T08:47:42Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million people globally, with an annual mortality of more than one million people. This high mortality rate highlights the need for in-depth study of anti-diabetic agents. This review explores the phytochemical contents and anti-diabetic mechanisms of M. charantia (cucurbitaceae). Studies show that M. charantia contains several phytochemicals that have hypoglycemic effects, thus, the plant may be effective in the treatment/management of diabetes mellitus. Also, the biochemical and physiological basis of M. charantia anti-diabetic actions is explained. M. charantia exhibits its anti-diabetic effects via the suppression of MAPKs and NF-κβin pancreatic cells, promoting glucose and fatty acids catabolism, stimulating fatty acids absorption, inducing insulin production, ameliorating insulin resistance, activating AMPK pathway, and inhibiting glucose metabolism enzymes (fructose-1,6-bisphosphate and glucose-6-phosphatase). Reviewed literature was obtained from credible sources such as PubMed, Scopus, and Web of Science. | ca_ES |
| dc.identifier.doi | https://doi.org/10.1016/j.heliyon.2022.e09253 | |
| dc.identifier.issn | 2405-8440 | |
| dc.identifier.uri | http://hdl.handle.net/10459.1/84759 | |
| dc.language.iso | eng | ca_ES |
| dc.publisher | Elsevier | ca_ES |
| dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.1016/j.heliyon.2022.e09253 | ca_ES |
| dc.relation.ispartof | Heliyon, 2022, vol. 8, núm. 4, art. 09253. | ca_ES |
| dc.rights | cc-by (c) Sunday Faith Oyelere et. al., 2022. | ca_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Momordica charantia | ca_ES |
| dc.subject | Diabetes mellitus | ca_ES |
| dc.subject | Anti-diabetic | ca_ES |
| dc.subject | Phytochemical | ca_ES |
| dc.subject | Cucurbitaceae | ca_ES |
| dc.subject | Hypoglycemic | ca_ES |
| dc.title | A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia | ca_ES |
| dc.type | info:eu-repo/semantics/article | ca_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |