Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort

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dc.contributor.authorZuil, María
dc.contributor.authorBenítez, Iván
dc.contributor.authorCabo Gambín, Ramón
dc.contributor.authorManzano Senra, Carlos
dc.contributor.authorMoncusí Moix, Anna
dc.contributor.authorGort Paniello, Clara
dc.contributor.authorde Gonzalo Calvo, David
dc.contributor.authorMolinero, Marta
dc.contributor.authorVengoechea Aragoncillo, José Javier
dc.contributor.authorComella, Thais
dc.contributor.authorBatlle Garcia, Jordi de
dc.contributor.authorTorres, Gerard
dc.contributor.authorTorres, Antoni
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorGonzález, Jessica
dc.date.accessioned2022-05-09T10:36:00Z
dc.date.available2022-05-09T10:36:00Z
dc.date.issued2021
dc.description.abstractThe objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (March-May 2020) and 233 in the second wave (July-December 2020). Clinical, epidemiological, prognostic and therapeutic data were compared. Patients of the first outbreak were older and more comorbid, presented worse PaO2/FiO2 ratio and an increased creatinine and D-dimer levels at hospital admission. The hospital stay was shorter (14.5[8;29] vs 8[6;14] days, p<0.001), ICU admissions (31.9% vs 13.3%, p<0.001) and the number of patients who required mechanical ventilation (OR = 0.12 [0.05–10.26]; p<0.001) were reduced. There were no significant differences in hospital and 30-day after discharge mortality (adjusted HR = 1.56; p = 0.1056) or hospital readmissions. New treatments and clinical strategies appear to improve hospital length, ICU admissions and the requirement for mechanical ventilation. However, we did not observe differences in mortality or readmissions.ca_ES
dc.description.sponsorshipSupported in part by ISCIII (CIBERESUCICOVID, COV20/00110), co-funded by ERDF, “Una manera de hacer Europa”. JdB acknowledges receiving financial support from Instituto de Salud Carlos III (Miguel Servet 2019: CP19/00108), co-funded by European Regional European Social Fund (ESF), “Investing in your future”. DdGC has received financial support from Instituto de Salud Carlos III (Miguel Servet 2020: CP20/00041), co-funded by the European Social Fund (ESF)/“Investing in your future”. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.ca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0258918
dc.identifier.idgrec031772
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/83247
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0258918ca_ES
dc.relation.ispartofPLoS One, 2021, vol. 16, núm. 10ca_ES
dc.rightscc-by (c) Authors, 2021ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleClinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohortca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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