Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation
| dc.contributor.author | Cambray Carner, Serafí | |
| dc.contributor.author | Pedraza González, Neus | |
| dc.contributor.author | Rafel i Borrell, Marta | |
| dc.contributor.author | Garí Marsol, Eloi | |
| dc.contributor.author | Aldea, Martí | |
| dc.contributor.author | Gallego, Carme | |
| dc.date.accessioned | 2015-05-07T11:59:42Z | |
| dc.date.available | 2015-05-07T11:59:42Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of transcripts and spatially controlled translational derepression once properly localized. There is growing evidence that translation is locally modulated as a result of specific synaptic inputs. However, the underlying molecular mechanisms that regulate this translational process are just emerging. We show that KIS, a serine/threonine kinase functionally related to microtubule dynamics and axon development, interacts with three proteins found in RNA granules: KIF3A, NonO, and eEF1A. KIS localizes to RNA granules and colocalizes with the KIF3A kinesin and the β-actin mRNA in cultured cortical neurons. In addition, KIS is found associated with KIF3A and 10 RNP-transported mRNAs in brain extracts. The results of knockdown experiments indicate that KIS is required for normal neurite outgrowth. More important, the kinase activity of KIS stimulates 3' untranslated region-dependent local translation in neuritic projections. We propose that KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals. | ca_ES |
| dc.identifier.doi | https://doi.org/10.1128/MCB.01180-08 | |
| dc.identifier.idgrec | 013329 | |
| dc.identifier.issn | 0270-7306 | |
| dc.identifier.uri | http://hdl.handle.net/10459.1/48183 | |
| dc.language.iso | eng | ca_ES |
| dc.publisher | American Society for Microbiology | ca_ES |
| dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.1128/MCB.01180-08 | ca_ES |
| dc.relation.ispartof | Molecular and cellular biology, 2009, vol. 29, núm. 3, p. 726-735 | ca_ES |
| dc.rights | (c) American Society for Microbiology, 2009 | ca_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
| dc.title | Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation | ca_ES |
| dc.type | article | ca_ES |
| dc.type.version | publishedVersion | ca_ES |