Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice

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dc.contributor.authorSandoval, Viviana
dc.contributor.authorFemenias, Antoni
dc.contributor.authorMartínez-Garza, Úrsula
dc.contributor.authorSanz-Lamora, Hèctor
dc.contributor.authorCastagnini, Juan Manuel
dc.contributor.authorQuifer Rada, Paola
dc.contributor.authorLamuela Raventós, Rosa Ma.
dc.contributor.authorMarrero González, Pedro F.
dc.contributor.authorHaro, Diego
dc.contributor.authorRelat, Joana
dc.date.accessioned2019-12-20T09:10:21Z
dc.date.available2019-12-20T09:10:21Z
dc.date.issued2019-09-01
dc.description.abstractMaqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A–stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.ca_ES
dc.description.sponsorshipThis study was supported by the Ministerio de Economía y Competitividad (grants AGL2017-82417-R to PFM and DH and AGL2016-75329-R to RML-R), by the Generalitat (grants 2017SGR683 and 2017SGR196), by the Associació Catalana de la Diabetis to JR (grant 600004—Ajut ACD a la recerca en diabetis 2017), Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (CIBEROBN—AEI/FEDER, UE). VS was supported by Conicyt’s fellowship from the Government of Chile. UM-G was supported by Conacyt’s fellowship from the Government of México. JMC was supported by BEC.AR fellowship from Ministerio de Educación, Cultura, Ciencia y Tecnología, Argentina. The APC was funded by the University of Barcelona.ca_ES
dc.identifier.doihttps://doi.org/10.3390/antiox8090360
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10459.1/67763
dc.language.isoengca_ES
dc.publisherMDPIca_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-82417-R/ES/INTERVENCIONES DIETETICAS SOBRE LA SEÑALIZACION DEL FGF21 PARA REDUCIR LA ESTEATOSIS HEPATICA/ca_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO//AGL2016-75329-R/ES/ca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/antiox8090360ca_ES
dc.relation.ispartofAntioxidants, 2019, vol. 8, núm. 9, article number 360ca_ES
dc.rightscc-by (c) Sandoval et al., 2019ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnthocyaninsca_ES
dc.subjectHigh-fat dietca_ES
dc.subjectMaqui berryca_ES
dc.subjectWhite adipose tissueca_ES
dc.titleLyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese miceca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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