The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies

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dc.contributor.authorMarín Sillué, Sònia
dc.contributor.authorCano Sancho, German
dc.contributor.authorSanchís Almenar, Vicente
dc.contributor.authorRamos Girona, Antonio J.
dc.date.accessioned2018-11-05T11:36:10Z
dc.date.available2019-09-21T22:16:27Z
dc.date.issued2018-09-19
dc.date.updated2018-11-05T11:36:11Z
dc.description.abstractMycotoxins are secondary metabolites produced by fungi that may contaminate different foods intended for human consumption, resulting in a widespread exposure worldwide. The novel exposome paradigm has the ambition to decipher the different environmental insults threating human health throughout the entire lifespan. Given the large potential impact of mycotoxins in terms of human exposure and related health effects, the ambition of this review is to present this group of chemical compounds and the high interest to be included in exposome projects. Furthermore, we also attempt to approach the novel exposome paradigm to more traditional disciplines such as mycotoxin exposure assessment and mycotoxicology, introducing the new methodological challenges and translational needs. Hence, we provide an overview of major biomarkers currently developed, biological matrices where these may be found, an overview of internal exposure levels and potential co-occurrence with environmental chemicals and finally an overview of major health effects with the illustrative example of the potent xenoestrogen zearalenol. Conversely, these new approaches may be an excellent opportunity to fill many research gaps on mycotoxins research as the identification of associations with human health, elucidation of join effect with other environmental exposures or the decipher of underlying molecular mechanisms by using advanced OMICs technologies.
dc.description.sponsorshipThe authors are grateful to the Spanish Ministry of Science, Innovation and Universities (Project AGL2017- 87755-R) for funding this work.
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.fct.2018.09.039
dc.identifier.idgrec027432
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10459.1/65026
dc.language.isoeng
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-87755-R/ES/TECNICAS DE SELECCION Y PROCESADO DE CEREALES, Y SU IMPACTO EN LA CONTAMINACION POR DEOXINIVALENOL EN ALIMENTOS INFANTILES/
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.fct.2018.09.039
dc.relation.ispartofFood and Chemical Toxicology, 2018, vol. 121, p. 504-518
dc.rightscc-by-nc-nd, (c) Elsevier, 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.subjectMycotoxins
dc.subjectExposome
dc.subjectBiomarkers
dc.subjectEnvironmental health
dc.titleThe role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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