Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
dc.contributor.author | Ribas i Fortuny, Judit | |
dc.contributor.author | Gómez Arbonés, Javier | |
dc.contributor.author | Boix Torras, Jacint | |
dc.date.accessioned | 2015-03-26T18:10:38Z | |
dc.date.available | 2015-03-26T18:10:38Z | |
dc.date.issued | 2005 | |
dc.date.updated | 2015-03-26T18:10:38Z | |
dc.description.abstract | Olomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma cell line, SH-SY5Y. The characterization of this process had suggested the involvement of an extrinsic pathway [Ribas, J., Boix, J., 2004. Cell differentiation, Caspase inhibition, and macromolecular synthesis blockage, but not Bcl-2 or Bcl-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. Exp. Cell Res. 295 9<br>24.], which depends on either Caspase 8 or Caspase 10 activation. However, neither Caspase 8 nor Caspase 10 is expressed in SH- SY5Y cells because of gene silencing. Upon Olomoucine or Roscovitine treatment, no re-expression of Caspase 8 or Caspase 10 was found. Therefore, in SH-SY5Y cells, this type of drugs is not triggering a canonical, Caspase 8/10-mediated, extrinsic apoptotic pathway. © 2005 Elsevier B.V. All rights reserved. | |
dc.format.mimetype | application/pdf | |
dc.identifier.doi | https://doi.org/10.1016/j.ejphar.2005.09.021 | |
dc.identifier.idgrec | 007155 | |
dc.identifier.issn | 0014-2999 | |
dc.identifier.uri | http://hdl.handle.net/10459.1/48115 | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejphar.2005.09.021 | |
dc.relation.ispartof | European Journal of Pharmacology, 2005, vol. 524, num. 1-3, p. 49-52 | |
dc.rights | (c) Elsevier, 2005 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.subject | Apoptosis | |
dc.subject | Cell Cycle | |
dc.subject | Caspases | |
dc.subject | Roscovitine | |
dc.subject | Olomoucine | |
dc.subject.classification | Apoptosi | |
dc.subject.classification | Cicle cel·lular | |
dc.subject.other | Apoptosis | |
dc.subject.other | Cell cycle | |
dc.title | Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs | |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | info:eu-repo/semantics/acceptedVersion |