Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients

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dc.contributor.authorBermúdez López, Marcelino
dc.contributor.authorPerpiñán, Hèctor
dc.contributor.authorAmigó, Núria
dc.contributor.authorCastro-Boqué, Eva
dc.contributor.authorAlonso, Núria
dc.contributor.authorMauricio Puente, Dídac
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorValdivielso Revilla, José Manuel
dc.date.accessioned2022-03-17T10:52:49Z
dc.date.available2022-03-17T10:52:49Z
dc.date.issued2021
dc.description.abstractBackground: Chronic kidney disease (CKD) patients have a high burden of atheromatous cardiovascular disease (ASCVD) not fully explained by traditional lipid parameters. Lipoprotein composition and subclass particle number information could improve ASCVD risk assessment. The objective of this study is to investigate the association of advanced lipoprotein parameters with the risk of atheromatosis in a subpopulation of the NEFRONA study. Methods: This was a cross-sectional study in 395 non-diabetic individuals (209 CKD and 186 non-diabetic and non-CKD) without statin therapy. Vascular ultrasound examination assessing 10 territories was combined with advanced lipoprotein testing performed by nuclear magnetic resonance spectroscopy. Logistic regression was used to estimate adjusted odds ratios (ORs) per 1 standard deviation increment. Results: Atheromatosis was more prevalent in CKD patients (33.9% versus 64.6%). After adjusting for age, gender, smoking habit and CKD stage, the amount of triglycerides (TGs) within low-density lipoprotein (LDL) lipoproteins was independently and positively associated with atheromatosis [OR 1.33; 95% confidence interval (CI) 1.03–1.74; P = 0.03]. Similarly, total and medium LDL particles (LDL-Ps) showed a positive association (OR 1.29; 95% CI 1.00–1.68; P = 0.05 and OR 1.34; 95% CI 1.04–1.75; P = 0.03, respectively). TG-loaded medium LDL-Ps were higher in CKD patients compared with controls and showed an adjusted OR of 1.40 (95% CI 1.09–1.82; P = 0.01) in non-diabetic patients (CKD and non-CKD individuals). In contrast, non-diabetic CKD patients showed a similar coefficient but the significance was lost (OR 1.2; 95% CI 0.8–1.7; P = 0.359). Conclusions: Non-diabetic CKD patients showed a higher amount of TG-loaded medium LDL-Ps compared with controls. These particles were independently associated with atheromatosis in non-diabetic patients.ca_ES
dc.description.sponsorshipThis work was supported by the intramural program of the IRB Lleida, the Instituto de Salud Carlos III [RETIC RD16/0009/0011, FIS PI18/00610], the Ministerio de Ciencia, Innovación y Universidades [IJC2018-037792-I] and the FEDER funds.ca_ES
dc.identifier.issn2048-8505
dc.identifier.issn2048-8513
dc.identifier.urihttp://hdl.handle.net/10459.1/73302
dc.language.isoengca_ES
dc.publisherEuropean Renal Association - European Dialysis and Transplant Association (ERA-EDTA)ca_ES
dc.publisherOxford University Pressca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1093/ckj/sfab113ca_ES
dc.relation.ispartofClinical Kidney Journal, 2021, vol. 14, núm. 12, 2591-2599ca_ES
dc.rightscc-by-nc (c)Authors, 2021ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAtherosclerosisca_ES
dc.subjectChronic kidney diseaseca_ES
dc.subjectDyslipidemiaca_ES
dc.subjectLDL cholesterolca_ES
dc.subjectLipoprotein subfractionsca_ES
dc.subjectTriglyceridesca_ES
dc.titleAdvanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patientsca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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