Association of BST-2 Gene Variants With HIV Disease Progression Underscores the Role of BST-2 in HIV Type 1 Infection

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dc.contributor.authorLaplana Lafaja, Marina
dc.contributor.authorCaruz, Antonio
dc.contributor.authorPineda, Juan Antonio
dc.contributor.authorPuig, Teresa
dc.contributor.authorFibla Palazón, Joan
dc.date.accessioned2020-02-12T10:06:56Z
dc.date.available2020-02-12T10:06:56Z
dc.date.issued2013-02-01
dc.date.updated2020-02-12T10:06:56Z
dc.description.abstractWe tested bone marrow stromal cell antigen 2 (BST-2) gene variants rs3217318, a 19-base-pair insertion/deletion polymorphism in the promoter region, and rs10415893, a tag single-nucleotide polymorphism in the 3′ untranslated region, for their association with human immunodeficiency virus type 1 (HIV-1) infection and disease progression. The study included 356 subjects exposed to HIV-1 (185 with and 171 without infection) and 188 controls. The first decrease in the CD4+ T-cell count to <200 cells/µL was used as the primary outcome, whereas the primary outcome plus initiation of any antiretroviral treatment was used as a secondary composite outcome. Association with progression was found for both rs3217318 and rs10415893, following an overdominant model. Diplotype analysis revealed faster progression to both outcomes for subjects carrying the Δ19_G/i19_A diplotype. Luciferase assay showed that a promoter sequence containing the i19 allele had the lowest expression levels, suggesting that i19 allele carriers could have less BST-2 expression, reducing their capability to retain viral particles. These results point to the relevance of BST-2 as a host genetic factor modifying HIV-1 disease progression.
dc.description.sponsorshipThis work was supported by Fondo de Investigaciones Sanitarias (references PI021476 and PI051778 to J. F. and reference PI021205 to A. C.), Fundació Marató TV3 (reference 020730 to J. F. and reference 020732 to A. C.), Fundación Progreso y Salud of the Consejería de Salud (Junta de Andalucía; reference AI-0021 [intensification grant] to J. A. P.), and the University of Lleida (fellowship to M. L.).
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jis685
dc.identifier.idgrec020781
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/10459.1/68001
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1093/infdis/jis685
dc.relation.ispartofJournal of Infectious Diseases, 2013, vol. 207, num. 3, p. 411-419
dc.rights(c) Laplana Lafaja, Marina et al., 2013
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectSNP
dc.subjectHIV/sida
dc.subjectHIV infection
dc.subjectGenética humana
dc.titleAssociation of BST-2 Gene Variants With HIV Disease Progression Underscores the Role of BST-2 in HIV Type 1 Infection
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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