Long-lived Humans Have a Unique Plasma Sphingolipidome

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dc.contributor.authorPradas Barriga, Irene
dc.contributor.authorJové Font, Mariona
dc.contributor.authorHuynh, Kevin
dc.contributor.authorInglés, Marta
dc.contributor.authorBorrás, Consuelo
dc.contributor.authorMota Martorell, Natàlia
dc.contributor.authorGalo-Licona, José Daniel
dc.contributor.authorPuig, Josep
dc.contributor.authorViña Ribes, José
dc.contributor.authorMeikle, Peter J.
dc.contributor.authorPamplona Gras, Reinald
dc.date.accessioned2022-07-15T12:28:59Z
dc.date.available2022-07-15T12:28:59Z
dc.date.issued2022
dc.description.abstractA species-specific lipidome profile is an inherent feature linked to longevity in the animal kingdom. However, there is a lack of lipidomic studies on human longevity. Here, we use mass spectrometry-based lipidomics to detect and quantify 151 sphingolipid molecular species and use these to define a phenotype of healthy humans with exceptional life span. Our results demonstrate that this profile specifically comprises a higher content of complex glycosphingolipids (hexosylceramides and gangliosides), and lower levels of ceramide species from the de novo pathway, sphingomyelin and sulfatide; while for ceramide-derived signaling compounds, their content remains unchanged. Our findings suggest that structural glycosphingolipids may be more relevant to achieve the centenarian condition than signaling sphingolipids.ca_ES
dc.description.sponsorshipWe acknowledge funding from the Spanish Ministry of Science, Innovation and Universities (RTI2018-099200-B-I00) and the Generalitat of Catalonia, Agency for management of University and Research Grants (2017SGR696) and Department of Health (SLT002/16/00250) to R.P., and Spanish Ministry of Education and Science (SAF2013-44663-R) and the ‘Red Tematica de Investigación Cooperativa en Envejecimiento y Fragilidad’ (RETICEF) (ISCIII2012-RED-43-029) to J.V. This study has been co-financed by FEDER funds from the European Union (“A way to build Europe”). I.P. was supported by a University of Lleida Predoctoral Fellowship. K.H. was supported by a Dementia Australia Research Foundation Scholarship.
dc.identifier.doihttps://doi.org/10.1093/gerona/glab360
dc.identifier.idgrec033113
dc.identifier.idgrec033113
dc.identifier.issn1758-535X
dc.identifier.issn1079-5006
dc.identifier.urihttp://hdl.handle.net/10459.1/83646
dc.language.isoengca_ES
dc.publisherOxford University Pressca_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099200-B-I00/ES/NEUROLIPIDOMICA DEL ENVEJECIMIENTO CEREBRAL HUMANO/
dc.relationinfo:eu-repo/grantAgreement/MINECO//SAF2013-44663-R/ES/IDENTIFICACION DE BIOMARCADORES DE FRAGILIDAD Y DE ESTRATEGIAS PARA SU PREVENCION Y TRATAMIENTO. CENTENARIOS COMO UN MODELO DE ENVEJECIMIENTOSALUDABLE/
dc.relation.ispartofThe Journals of Gerontology Series A, 2022, , vol. 77, núm. 4, p. 728–735ca_ES
dc.rightscc-by (c) The Author(s), 2021ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAgingca_ES
dc.subjectCentenariansca_ES
dc.subjectCeramidesca_ES
dc.subjectGlycosphingolipidsca_ES
dc.subjectMass spectrometryca_ES
dc.titleLong-lived Humans Have a Unique Plasma Sphingolipidomeca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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