ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status
dc.contributor.author | Barés Junqué, Gisel | |
dc.contributor.author | Beà Tàrrega, Aida | |
dc.contributor.author | Hernández, Luís | |
dc.contributor.author | Navaridas Fernández de Bobadilla, Raúl | |
dc.contributor.author | Felip Nogués, Isidre | |
dc.contributor.author | Megino-Luque, Cristina | |
dc.contributor.author | Blasco Angulo, Natividad | |
dc.contributor.author | Nadeu, Ferran | |
dc.contributor.author | Campo, Elías | |
dc.contributor.author | Llovera i Tomàs, Marta | |
dc.contributor.author | Dolcet Roca, Xavier | |
dc.contributor.author | Sanchis, Daniel | |
dc.date.accessioned | 2021-09-03T10:40:12Z | |
dc.date.available | 2021-09-03T10:40:12Z | |
dc.date.issued | 2021 | |
dc.description.abstract | EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG deficiency reduced proliferation of endometrial tumor cells expressing low PTEN/high p-AKT levels, and Endog deletion blunted the growth of PTEN-deficient 3D endometrial cultures. Furthermore, ENDOG silencing reduced proliferation of follicular thyroid carcinoma and glioblastoma cell lines with high p-AKT expression. High ENDOG expression was associated with a short time to treatment in a cohort of patients with chronic lymphocytic leukemia (CLL), a B-cell lymphoid neoplasm with activation of PI3K/AKT. This clinical impact was observed in the less aggressive CLL subtype with mutated IGHV in which high ENDOG and low PTEN levels were associated with worse outcome. In summary, our results show that reducing ENDOG expression hinders growth of some tumors characterized by low PTEN activity and high p-AKT expression and that ENDOG has prognostic value for some cancer types. | ca_ES |
dc.description.sponsorship | This research was funded by Ministerio de Ciencia, Innovación y Universidades, Gobierno de España, grant numbers SAF2013-44942-R and PID2019-104509RB-I00 to D.S.; grant numbers SAF2016-80157-R and PID2019-104734RB-I00 to X.D.; Fundació La Marató TV3, grant number 20153810 to D.S. G.B. holds a contract from the University of Lleida; A.B. holds a contract from Fundació La Marató TV3 and IRBLleida/Diputació de Lleida; The Spanish Ministry of Science and Innovation (MICINN) through the Instituto de Salud Carlos III (ISCIII) International Cancer Genome Consortium for Chronic Lymphocytic Leukemia (ICGC-CLL Genome Project) to E.C.. Fundació La Marato de TV3 (201920-30) to L.H. Support Groups de Recerca AGAUR 2014-SGR-795 of the Generalitat de Catalunya to E.C. | ca_ES |
dc.identifier.doi | https://doi.org/10.3390/cancers13153803 | |
dc.identifier.idgrec | 031810 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | http://hdl.handle.net/10459.1/71796 | |
dc.language.iso | eng | ca_ES |
dc.publisher | MDPI | ca_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO//SAF2013-44942-R/ES/VIAS DE SEÑALIZACION PARA DESARROLLO Y MUERTE CELULAR EN EL MIOCARDIO: ESTUDIO INTEGRATIVO PARA SU COMPRENSION E IDENTIFICACION DE DIANAS TERAPEUTICAS/ | ca_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104509RB-I00/ES/MECANISMOS IMPLICADOS EN EL PAPEL DE ENDOG EN EL DESARROLLO Y EL METABOLISMO DEL CORAZON. RELACION DE ENDOG Y OTROS GENES APOPTOTICOS CON LA PATOFISIOPATOLOGIA CARDIACA/ | ca_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO//SAF2016-80157-R/ES/ | ca_ES |
dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.3390/cancers13153803 | ca_ES |
dc.relation.ispartof | Cancers, 2021, vol. 13, núm. 15, 3803 | ca_ES |
dc.rights | cc-by (c) Barés et al., 2021 | ca_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | ENDOG | ca_ES |
dc.subject | PTEN | ca_ES |
dc.subject | AKT | ca_ES |
dc.subject | Endometrial carcinoma | ca_ES |
dc.subject | Glioblastom | ca_ES |
dc.subject | Chronic lymphocytic leukemia | ca_ES |
dc.title | ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status | ca_ES |
dc.type | info:eu-repo/semantics/article | ca_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |