Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development

Simple item page
dc.contributor.authorGarcía López, Margarita
dc.contributor.authorAbellán Ródenas, Antonio
dc.contributor.authorLegaz, Isabel
dc.contributor.authorRubenstein, John L.R.
dc.contributor.authorPuelles, Luis
dc.contributor.authorMedina Hernández, Loreta Mª
dc.date.accessioned2017-01-19T11:58:04Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2008
dc.description.abstractThe amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections are suggested to show a cortico-striato-pallidal organization similar to that of the basal ganglia (Swanson [2000] Brain Res 886:113–164). To test this model we investigated the embryological origin and molecular properties of the mouse centromedial and extended amygdalar subdivisions, which constitute major sources of descending projections. We analyzed the distribution of key regulatory genes that show restricted expression patterns within the subpallium (Dlx5, Nkx2.1, Lhx6, Lhx7/8, Lhx9, Shh, and Gbx1), as well as genes considered markers for specific subpallial neuronal subpopulations. Our results indicate that most of the centromedial and extended amygdala is formed by cells derived from multiple subpallial subdivisions. Contrary to a previous suggestion, only the central—but not the medial—amygdala derives from the lateral ganglionic eminence and has striatal-like features. The medial amygdala and a large part of the extended amygdala (including the bed nucleus of the stria terminalis) consist of subdivisions or cell groups that derive from subpallial, pallial (ventral pallium), or extratelencephalic progenitor domains. The subpallial part includes derivatives from the medial ganglionic eminence, the anterior peduncular area, and possibly a novel subdivision, called here commissural preoptic area, located at the base of the septum and related to the anterior commissure. Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala. J. Comp. Neurol. 506:46–74, 2008. © 2007 Wiley-Liss, Inc.ca_ES
dc.description.sponsorshipGrant sponsor: Spanish Ministry of Science and Technology (DGICYTFEDER); Grant numbers: BFI2003-06453-C02-02, BFU2006-14804-C02-02/ BFI (to L.M.); BFU2005-09378, C01-C02/BFI (to L.P.); Grant sponsor: Health Institute Carlos III-FEDER; Grant number: 01/0057-02 (to L.M.); Grant sponsor: Se´neca Foundation; Grant number: PB/50/FS/02 (to L.M.); Grant sponsor: Nina Ireland (to J.L.R.R.); Grant sponsor: National Institute of Mental Health (NIMH); Grant number: K05 MH065670 (to J.L.R.R.).ca_ES
dc.identifier.doihttps://doi.org/10.1002/cne.21524
dc.identifier.idgrec011378
dc.identifier.issn0021-9967
dc.identifier.urihttp://hdl.handle.net/10459.1/59043
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMICYT/PN2000-2003/BFI2003-06453-C02-02
dc.relationMIECI/PN2004-2007/BFU2006-14804-C02-02/ BFI
dc.relationMIECI/PN2004-2007/BFU2005-09378-C01/BFI
dc.relationMIECI/PN2004-2007/BFU2005-09378-C02/BFI
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/cne.21524ca_ES
dc.relation.ispartofThe Journal of Comparative Neurology, 2008, vol. 506, núm. 1, p. 46–74ca_ES
dc.rights(c) Wiley-Liss, Inc. 2007ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.subjectSubpallial amygdalaca_ES
dc.subjectVentral pallial amygdalaca_ES
dc.subjectBed nucleus of the stria terminalisca_ES
dc.subjectPreoptic regionca_ES
dc.titleHistogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during developmentca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Articles publicats (Medicina Experimental)
Articles publicats (IRBLleida)
Publicacions de projectes de recerca del Plan Nacional