Avoid Postoperative Pain To Prevent Its Chronification: A Narrative Review

dc.contributor.authorMontero Matamala, Antonio
dc.contributor.authorHanna, Magdi
dc.contributor.authorPerrot, Serge
dc.contributor.authorVarrassi, Giustino
dc.date.accessioned2022-12-18T09:06:41Z
dc.date.available2022-12-18T09:06:41Z
dc.date.issued2022
dc.description.abstractAcute postoperative pain is a normal and expected part of the patient’s postsurgical trajectory, and its intensity, severity, and duration vary with surgery-related and patient factors. In a subset of patients, postoperative pain does not resolve as the tissue heals but instead transitions to chronic postoperative pain, a challenging condition to treat and one associated with decreased quality of life, sleep and mood disorders, and neuropathy. Promptly and adequately treating acute postoperative pain can reduce the risk that it will transition into chronic postoperative pain. Numerous agents are available that may help treat postoperative pain, including nonsteroidal anti-inflammatory drugs, opioids, antidepressants, anticonvulsants, and others. In this connection, it is also important to consider patient factors, such as mental health status and comorbidities, as well as the type and duration of surgery. A multimodal approach is recommended, which uses two or more agents with complementary mechanisms of action, working at different targets. Multimodal analgesia may also reduce adverse events and lessen opioid consumption after surgery. A particularly useful fixed-dose combination product is dexketoprofen/tramadol (DEX-TRA), which is safe and effective in numerous clinical trials. This review is based on a presentation from the Roma Pain Days scientific sessions of 2021.ca_ES
dc.identifier.doihttps://doi.org/10.7759/cureus.22243
dc.identifier.issn2168-8184
dc.identifier.urihttp://hdl.handle.net/10459.1/84885
dc.language.isoengca_ES
dc.publisherCureusca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.7759/cureus.22243ca_ES
dc.relation.ispartofCureus, 2022, vol. 14, núm. 2, art. 22243.ca_ES
dc.rightscc-by (c) Antonio Montero Matamala et. al., 2022.ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDexketoprofenca_ES
dc.subjectTramadolca_ES
dc.subjectDrugs fixed dose combination (fdc)ca_ES
dc.subjectMultimodal analgesiaca_ES
dc.subjectPain chronificationca_ES
dc.subjectAcute painca_ES
dc.titleAvoid Postoperative Pain To Prevent Its Chronification: A Narrative Reviewca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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