Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice

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dc.contributor.authorJové Font, Mariona
dc.contributor.authorNaudí i Farré, Alba
dc.contributor.authorRamírez-Núñez, Omar
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorSelman, Colin
dc.contributor.authorWithers, Dominic J.
dc.contributor.authorPamplona Gras, Reinald
dc.date.accessioned2015-09-23T09:59:09Z
dc.date.available2015-09-23T09:59:09Z
dc.date.issued2014-10-01
dc.date.updated2015-09-23T09:59:09Z
dc.description.abstractLipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles. In this study, we employ a liquid chromatography quadrupole time-of-flight-based methodology to demonstrate that CR in the liver of male C57BL/6 mice: (i) induces marked changes in the cellular lipidome, (ii) specifically reduces levels of a phospholipid peroxidation product, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphatidylcholine, (iii) alters cellular phosphoethanolamine and triglyceride distributional profiles, (iv) affects mitochondrial electron transport chain complexes, increasing complex II and decreasing complex III and (v) is associated with specific changes in liver metabolic pathways. These data demonstrate that CR induces a specific lipidome and metabolome reprogramming event in mouse liver which is associated with lower protein oxidative damage, as assessed by mass spectrometry-based measurements. Such changes may be critical to the increased lifespan and healthspan observed in C57BL/6 mice following CR.
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/acel.12241
dc.identifier.idgrec021864
dc.identifier.issn1474-9718
dc.identifier.urihttp://hdl.handle.net/10459.1/48741
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisherAnatomical Society
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1111/acel.12241
dc.relation.ispartofAging Cell, 2014, vol. 13, num. 5, p. 828-837
dc.rightscc-by (c) Jové Font, Mariona et al., 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.subject.classificationMetabolisme dels lípids
dc.subject.classificationMalalties del fetge
dc.subject.otherLipid metabolism
dc.subject.otherLiver diseases
dc.titleCaloric restriction reveals a lipidomic and metabolomic signature in liver of male mice
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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