Novel and efficient biotechnological approach to produce 2,5-diformylfuran from biomass-derived 5-hydroxymethylfurfural

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dc.contributor.authorMillán Acosta, Alberto
dc.contributor.authorCuesta Turull, Clara
dc.contributor.authorCosovanu, Diana Gabriela
dc.contributor.authorSala i Martí, Núria
dc.contributor.authorCanela i Garayoa, Ramon
dc.date.accessioned2021-12-03T12:28:26Z
dc.date.available2021-12-03T12:28:26Z
dc.date.issued2021
dc.description.abstractThe preparation of compounds of interest from biomass-derived 5-hydroxymethylfurfural (HMF) has attracted considerable attention. One such compound is 2,5-diformylfuran (DFF), obtained through oxidation of the hydroxyl group of HMF. Herein, we describe for the first time the whole-cell oxidation of HMF to DFF by Fusarium culmorum EAN 51. Although the chemocatalytic transformation of HMF into DFF has been widely studied, biocatalytic processes have been scarcely reported and are limited to enzymatic synthesis using the combination of several enzymes. The whole-cell transformation of HMF into DFF is preferable thanks to the inherent presence of the different enzymes, significantly reducing the cost of the process. F. culmorum showed a high capability to reduce to 2,5-di(hydroxymethyl)furan (DHMF) and oxidize to DFF the substrate with high yields depending on the nitrogen source and the concentration of peptone and glucose in the media, which highly affected the redox capability of this strain. After careful optimization of the concentration of both nutrients through response surface methodology, 50 mM HMF were transformed into DFF with a high yield (92%) and selectivity (94%). These results open a new line of investigation in the sustainable production of DFF from renewable biobased resources.ca_ES
dc.description.sponsorshipThis work was partially supported by the Spanish Government (PID2019-110735RB-C21, MICIN/FEDER) and the Catalan Government (FI_B1_00135).ca_ES
dc.format.extent9 p.ca_ES
dc.identifier.doihttps://doi.org/10.1021/acssuschemeng.1c05308
dc.identifier.idgrec032245
dc.identifier.issn14550–14558
dc.identifier.urihttp://hdl.handle.net/10459.1/72486
dc.language.isoengca_ES
dc.publisherAmerican Chemical Societyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1021/acssuschemeng.1c05308ca_ES
dc.relation.ispartofACS Sustainable Chemistry & Engineering, 2021, vol. 9, núm. 43, p. 1-9ca_ES
dc.rightscc-by (c) Acosta et al., 2021ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDFFca_ES
dc.subjectHMFca_ES
dc.subjectBiocatalysisca_ES
dc.subjectFusarium culmorumca_ES
dc.subjectRSMca_ES
dc.subjectBiotransformationca_ES
dc.subject.otherBiotecnologiaca_ES
dc.subject.otherBiomassaca_ES
dc.titleNovel and efficient biotechnological approach to produce 2,5-diformylfuran from biomass-derived 5-hydroxymethylfurfuralca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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