Alzheimer’s disease mutant mice exhibit reduced brain tissue stiffness compared to wild-type mice in both normoxia and following intermittent hypoxia mimicking sleep apnea

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dc.contributor.authorMenal Castellote, Maria José
dc.contributor.authorJorba, Ignasi
dc.contributor.authorTorres, Marta
dc.contributor.authorMontserrat i Capdevila, Josep
dc.contributor.authorGozal, David
dc.contributor.authorColell, Anna
dc.contributor.authorPiñol Ripoll, Gerard
dc.contributor.authorNavajas, Daniel
dc.contributor.authorAlmendros, Isaac
dc.contributor.authorFarré, Ramon
dc.date.accessioned2018-02-19T11:50:14Z
dc.date.available2018-02-19T11:50:14Z
dc.date.issued2018
dc.description.abstractBackground: Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer’s disease (AD) and that AD is associated with reduced brain tissue stiffness. Aim: To investigate whether intermittent hypoxia (IH) alters brain cortex tissue stiffness in AD mutant mice exposed to IH mimicking OSA. Methods: Six-eight month old (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) AD mutant mice and wild-type (WT) littermates were subjected to IH (21% O2 40 s to 5% O2 20 s; 6 h/day) or normoxia for 8 weeks. After euthanasia, the stiffness (E) of 200-μm brain cortex slices was measured by atomic force microscopy. Results: Two-way ANOVA indicated significant cortical softening and weight increase in AD mice compared to WT littermates, but no significant effects of IH on cortical stiffness and weight were detected. In addition, reduced myelin was apparent in AD (vs. WT), but no significant differences emerged in the cortex extracellular matrix components laminin and glycosaminoglycans when comparing baseline AD and WT mice. Conclusion: AD mutant mice exhibit reduced brain tissue stiffness following both normoxia and IH mimicking sleep apnea, and such differences are commensurate with increased edema and demyelination in AD.ca_ES
dc.description.sponsorshipThis work was supported in part by Fundació Marató TV3 (20143231), the Spanish Ministry of Economy and Competitiveness—Instituto de Salud Carlos III (FIS-PI14/00004, FIS-PI14/00280) and SEPAR (139/2015). This work was partially funded by the CERCA Programme of Generalitat de Catalunya.ca_ES
dc.identifier.doihttps://doi.org/10.3389/fneur.2018.00001
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/10459.1/62678
dc.language.isoengca_ES
dc.publisherFrontiers Mediaca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.3389/fneur.2018.00001ca_ES
dc.relation.ispartofFrontiers in Neurology, 2018, vol. 9, núm. 1, p. 1-8ca_ES
dc.rightscc-by (c) Menal et al., 2018ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAlzheimer’s disease mutant mice exhibit reduced brain tissue stiffness compared to wild-type mice in both normoxia and following intermittent hypoxia mimicking sleep apneaca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
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