Telomere length is a prognostic factor for overall survival in colorectal cancer

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dc.contributor.authorValls i Bautista, Cristina
dc.contributor.authorPiñol Felis, Carme
dc.contributor.authorReñé Espinet, Josep Maria
dc.contributor.authorBuenestado Garcia, Juan
dc.contributor.authorViñas Salas, Joan
dc.date.accessioned2016-06-01T09:49:14Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2011
dc.description.abstractAim The aim of this study was to determine whether telomere length is an independent prognostic factor for the prevention and survival of colorectal cancer. Method Terminal restriction fragment (TRF) length was determined by Southern blot in tumours and paired normal tissue samples from 147 patients with sporadic colorectal cancer who had undergone surgery. The TRF length ratio (TRFLR) was determined as the ratio between the length of the patient’s tumour and normal tissue.The classification and regression tree technique was used to determine optimal cut-off values (£ 1 or > 1). Results Mean TRF length was 6.79 Kbp (1.19–13.99) in tumour tissue and 7.81 Kbp (3.63–15.70) in normal mucosa (P < 0.001). Mean TRFLR was 0.88. Telomere length and telomere length ratio were not correlated with any clinicopathological factors. In univariate analysis, overall survival was related to N stage (lymph node + ⁄ ); P = 0.002), TNM classification (P = 0.019) and TRFLR (£ 1 or > 1; P = 0.014). In multivariate analysis, overall survival was significantly associated with TRFLR and N stage. Colorectal cancer patients with TRFLR £ 1 and negative lymph node involvement had a higher overall survival rate. Conclusion Telomere length ratio is an independent prognostic factor for survival in colorectal cancer patients, and the telomere lengths in the normal and tumour mucosa of the same patient present with parallel behaviour.ca_ES
dc.description.sponsorshipThe present work has been supported by grants from the Fondo de Investigaciones Sanitarias (Health Research Fund) (01 ⁄ 0620) and FEDER. C. Valls was supported by a predoctoral grant from the Generalitat de Catalunyaca_ES
dc.identifier.doihttps://doi.org/10.1111/j.1463-1318.2010.02433.x
dc.identifier.idgrec019771
dc.identifier.issn1462-8910
dc.identifier.urihttp://hdl.handle.net/10459.1/57144
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1111/j.1463-1318.2010.02433.xca_ES
dc.relation.ispartofColorectal Disease, 2011, vol. 13, núm.11ca_ES
dc.rights(c) Wiley, 2011ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.subjectTelomere lengthca_ES
dc.subjectColorectal cancerca_ES
dc.subjectPrognosisca_ES
dc.titleTelomere length is a prognostic factor for overall survival in colorectal cancerca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
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