Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth

dc.contributor.authorGómez Vilarrubla, Ariadna
dc.contributor.authorMas Parés, Berta
dc.contributor.authorDíaz, Marta
dc.contributor.authorXargay Torrent, Sílvia
dc.contributor.authorCarreras Badosa, Gemma
dc.contributor.authorJové Font, Mariona
dc.contributor.authorMartín Garí, Meritxell
dc.contributor.authorBonmatí Santané, Alexandra
dc.contributor.authorZegher, Francis de
dc.contributor.authorIbáñez, Lourdes
dc.contributor.authorLópez Bermejo, Abel
dc.contributor.authorBassols, Judit
dc.date.accessioned2021-11-24T12:36:29Z
dc.date.available2021-11-24T12:36:29Z
dc.date.issued2021
dc.description.abstractIntroduction: Fatty acids are essential nutrients for the fetus and are supplied by the mother through the placenta. Desaturase and elongase enzymes play an important role in modulating the fatty acid composition of body tissues. We aimed to compare the fatty acid profile and the estimated desaturase and elongase activities in the placenta of appropriate (AGA) versus small-for-gestational-age (SGA), and to determine their relationship with the offspring size at birth. Methods: The placental fatty acid profile was analyzed by gas chromatography in 84 infants (45 AGA and 30 SGA) from a prenatal cohort study. The estimated desaturase and elongase activities were calculated from productprecursor fatty acid ratios. Results were associated with maternal (age, body mass index and weight gain during gestation) and neonatal (gestational age, sex, birth weight and birth length) parameters. Results: Differences in placental fatty acid composition between AGA and SGA infants rather than correlations thereof with neonatal parameters were observed. Placentas from SGA infants contained lower levels of omega-3 (ALA, EPA, DPA, and DHA) and high omega-6/omega-3 ratios (AA/DHA and LA/ALA), as well as low elongase (Elovl5) and high desaturase (D9Dn7 and D5Dn6) activity as compared to AGA infants (all p < 0.0001). Discussion: Placentas of AGA and SGA infants differed in fatty acids profile as well as in estimated desaturase and elongase activities. A striking feature of SGA placentas was the low availability of omega-3. Hence, omega-3 fatty acid status deserves further attention, as a potential target of prenatal interventions.ca_ES
dc.description.sponsorshipThis study was supported by grants from the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (ISCIII), Madrid, Spain (PI17/ 00557 and PI19/00451 to JB), projects co-funded by FEDER (Fondo Europeo de Desarrollo Regional).ca_ES
dc.identifier.doihttps://doi.org/10.1016/j.placenta.2021.04.009
dc.identifier.idgrec031979
dc.identifier.issn0143-4004
dc.identifier.urihttp://hdl.handle.net/10459.1/72405
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.placenta.2021.04.009ca_ES
dc.relation.ispartofPlacenta, 2021, vol. 109, p. 4-10ca_ES
dc.rightscc-by-nc-nd (c) Gómez et al., 2021ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPlacentaca_ES
dc.subjectFatty acidsca_ES
dc.subjectSGAca_ES
dc.subjectDesaturase and elongaseca_ES
dc.titleFatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birthca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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