Factors associated to duration of hepatitis A outbreaks: implications for control

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dc.contributor.authorTorner Gràcia, Núria
dc.contributor.authorBroner, Sonia
dc.contributor.authorMartínez, Ana
dc.contributor.authorTortajada, Cecilia
dc.contributor.authorGarcia de Olalla, Patricia
dc.contributor.authorBarrabeig i Fabregat, Irene
dc.contributor.authorSala, Maria Rosa
dc.contributor.authorCamps, Neus
dc.contributor.authorMinguell, Sofia
dc.contributor.authorÁlvarez, Josep
dc.contributor.authorFerrús, Gloria
dc.contributor.authorTorra, Roser
dc.contributor.authorGodoy i García, Pere
dc.contributor.authorDomínguez García, Àngela
dc.date.accessioned2015-05-19T11:11:00Z
dc.date.available2015-05-19T11:11:00Z
dc.date.issued2012
dc.description.abstractEven though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as $2 epidemiologically-linked cases with $1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 105 persons-year) were reported. Factors associated with shorter duration were time to intervention (OR = 0.96; 95% CI: 0.94–0.98) and school setting (OR = 0.39; 95% CI: 0.16–0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (OR = 0.96; 95% CI: 0.95–0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration.ca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0031339
dc.identifier.idgrec017722
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/48240
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1371/journal.pone.0031339ca_ES
dc.relation.ispartofPLoS One, 2012, vol. 7, núm. 2, e31339ca_ES
dc.rightscc-by, (c) Torner et al., 2012ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleFactors associated to duration of hepatitis A outbreaks: implications for controlca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
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