Differential expression of LIM-Homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds

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dc.contributor.authorAbellán Ródenas, Antonio
dc.contributor.authorMenuet, Arnaud
dc.contributor.authorDehay, Colette
dc.contributor.authorMedina Hernández, Loreta Mª
dc.contributor.authorRétaux, Sylvie
dc.date.accessioned2017-01-19T10:46:13Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2010
dc.description.abstractReelin-expressing Cajal-Retzius (CR) cells are among the earliest generated cells in the mammalian cerebral cortex and are believed to be crucial for both the development and the evolution of a laminated pattern in the pallial wall of the telencephalon. LIMhomeodomain (LIM-hd) transcription factors are expressed during brain development in a highly restricted and combinatorial manner, and they specify regional and cellular identity. We have investigated the expression of the LIM-hd members Lhx1/Lhx2/Lhx5/ Lhx6/Lhx9 in the reelin-expressing cells, the pallium, and the regions of origin of CR cells including the cortical hem of 3 amniote species: the mouse, the chick, and the macaque monkey. We found major differences in the combinatorial LIM-hd expression in the marginal zone as well as in the hem. 1) Lhx5 is a ‘‘preferential LIMhd’’ for CR cells in mammals but not expressed by these cells in chicks. 2) Lhx2 is expressed in the hem of the chick, whereas it is excluded from this region in mouse. 3) Whereas mouse CR cells express Lhx5/Lhx1, their monkey counterparts express 4 of these factors: Lhx1/Lhx2/Lhx5/Lhx9. We discuss our findings in evolutionary terms for the specification of the midline hem and CR cell type and the emergence of the cortical lamination pattern.ca_ES
dc.description.sponsorshipThis work was supported by Centre National de la Recherche Scientifique (CNRS), Agence Nationale pour la Recherche (ANR-Neuro [MIDLINE]) to S.R.; Agence Nationale pour la Recherche (ANR [06-NEUR-010-01]), SECO (EU FP7-216593) to C.D.; Spanish Ministry of Education and Science and FEDER (DGICYT-FEDER grant no. BFU2006-14804-C02-02/BFI) to L.M. A.M. was a postdoctoral fellow supported by CNRS.ca_ES
dc.identifier.doihttps://doi.org/10.1093/cercor/bhp242
dc.identifier.idgrec015563
dc.identifier.issn1047-3211
dc.identifier.urihttp://hdl.handle.net/10459.1/59035
dc.language.isoengca_ES
dc.publisherOxford Journalsca_ES
dc.relationMIECI/PN2004-2007/BFU2006-14804-C02-02/BFI
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1093/cercor/bhp242ca_ES
dc.relation.ispartofCerebral Cortex, 2010, vol. 20, núm. 8, p. 1788-1798ca_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/216593
dc.rights(c) Oxford Journals, 2009ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.subjectCortexca_ES
dc.subjectEvolutionca_ES
dc.subjectLIM codeca_ES
dc.subjectPalliumca_ES
dc.titleDifferential expression of LIM-Homeodomain factors in Cajal-Retzius cells of primates, rodents, and birdsca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
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