Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study

dc.contributor.authorAlcubierre Calvo, Núria
dc.contributor.authorNavarrete Muñoz, Eva María
dc.contributor.authorRubinat, Esther
dc.contributor.authorFalguera, Mireia
dc.contributor.authorValls Marsal, Joan
dc.contributor.authorTraveset Maeso, Alicia
dc.contributor.authorVilanova Fillat, María Belén
dc.contributor.authorMarsal Mora, Josep Ramon
dc.contributor.authorHernández García, Marta
dc.contributor.authorGranado Casas, Minerva
dc.contributor.authorMartínez González, María Dolores
dc.contributor.authorJurjo Campo, Carmen
dc.contributor.authorFranch-Nadal, Josep
dc.contributor.authorVioque, Jesus
dc.contributor.authorMauricio Puente, Dídac
dc.description.abstractBackground: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. Methods: In this case–control study, we included a total of 146 patients with DR and 148 without DR. The intake of macronutrient was evaluated using a validated food frequency questionnaire. We used logistic regression adjusted for sex, age, diabetes duration, energy intake, educational level, physical activity, waist circumference, systolic blood pressure, high-density lipoprotein cholesterol and diabetes treatment, to estimate odds ratio (ORs) of DR. Results: Patients with DR had significantly lower intake of fibre, monounsaturated fatty acids (MUFA), and palmitic and oleic acid. Inverse associations were observed between MUFA and oleic acid intake in DR. Subjects with intermediate and high MUFA intake were less likely to have DR than those with lower MUFA intake, with ORs of 0. 46 (95 % CI: 0.22–0.93) and 0.42 (95 % CI: 0.18–0.97), respectively. Similarly, intermediate and high oleic acid intake were associated with reduced DR frequency compared with low oleic acid intake, with OR values of 0.48 (95 % CI: 0. 23–0.97) and 0.37 (95 % CI: 0.16–0.85), respectively. These associations were stronger in patients with a longer diabetes duration. Conclusion: In type 2 diabetes mellitus, MUFA and oleic acid intake were inversely associated with DR.ca_ES
dc.description.sponsorshipThis study was supported by grant PS09/01035 from Instituto of Salud Carlos III. N.A holds a predoctoral fellowship from Instituto of Salud Carlos III FI11/ 0008. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative included in Plan Nacional de I + D + I and cofinanced by Instituto de Salud Carlos III Subdireccion General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER).ca_ES
dc.publisherBioMed Centralca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofNutrition and Metabolism, 2016, vol. 13, núm. 40ca_ES
dc.rightscc-by (c) Alcubierre et al., 2016ca_ES
dc.subjectDiabetic retinopathyca_ES
dc.subjectOleic acidca_ES
dc.subjectMonounsaturated fatty acidsca_ES
dc.subjectFatty acidsca_ES
dc.titleAssociation of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control studyca_ES
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