Vitamin D receptor levels in colorectal cancer. Possible role of BsmI polymorphism

dc.contributor.authorParisi Capdevila, Eva
dc.contributor.authorReñé Espinet, Josep Maria
dc.contributor.authorCardús i Figueras, Anna
dc.contributor.authorValcheva, Petya
dc.contributor.authorPiñol Felis, Carme
dc.contributor.authorValdivielso Revilla, José Manuel
dc.contributor.authorFernández i Giráldez, Elvira
dc.date.accessioned2016-06-06T11:01:37Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2008
dc.description.abstractA high expression of vitamin D receptor (VDR) in colorectal cancer (CRC) tumoral tissue has been related to a good prognosis and it has been proposed that it could be a good biological marker of CRC progression. Nevertheless, there are no previous studies that compare the VDR expression in tumoral towards normal tissue of the same CRC patient in relation to VDR BsmI genotype. We collected normal and tumoral tissue samples, as well as blood samples, from CRC patients (n = 170) and controls (n = 122). VDR genotyping was performed and BsmI homozygous patients were selected (CRC = 50, Cont = 32). VDR mRNA and protein levels were analyzed. We also measured 25-Hydroxyvitamin D serum levels. We found no differences in the polymorphism distribution in tumoral versus normal tissue (control: BB = 15.7%, bb = 41.3%, Bb = 43%; CRC: BB = 14.2%, bb = 41.9%, Bb = 43.9%). Furthermore, VDR levels decreased in colonic cancer tissue (mean: 3.03) versus normal mucosa (11.62) from the same patient (p < 0.001), but this decrease was similar in both genotypes. There were differences in 25-Hydroxyvitamin D3 levels between the CRC and the control group (CRC = 8.65 ng/ml, Cont = 18.15 ng/ml). In conclusion, we found a decrease in VDR levels in tumoral compared with normal mucosa from the same patient. This difference is independent of the BsmI polymorphism.ca_ES
dc.description.sponsorshipThis work was supported by Fundacio Dr Pifarré grants, FIS ´ PI07/0427, PI06/0010 and REDINREN (16/06).ca_ES
dc.identifier.doihttps://doi.org/10.1016/j.jsbmb.2008.05.001
dc.identifier.idgrec012524
dc.identifier.issn0960-0760
dc.identifier.urihttp://hdl.handle.net/10459.1/57167
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.jsbmb.2008.05.001ca_ES
dc.relation.ispartofJournal of Steroid Biochemistry & Molecular Biology, 2008, vol. 111, núm. 1-2, p. 87-90ca_ES
dc.rights(c) Elsevier, 2008ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.subjectVitamin Dca_ES
dc.subjectColon cancerca_ES
dc.subjectVDRca_ES
dc.subjectBsmlca_ES
dc.titleVitamin D receptor levels in colorectal cancer. Possible role of BsmI polymorphismca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
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