Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort

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dc.contributor.authorAgier, Lydiane
dc.contributor.authorBasagaña Flores, Xavier
dc.contributor.authorMaitre, Lea
dc.contributor.authorGranum, Berit
dc.contributor.authorBird, Philippa K.
dc.contributor.authorCasas Sanahuja, Maribel
dc.contributor.authorOftedal, Bente
dc.contributor.authorWright, John
dc.contributor.authorAndrusaityte, Sandra
dc.contributor.authorde Castro, Montserrat
dc.contributor.authorCequier Manciñeiras, Enrique
dc.contributor.authorChatzi, Leda
dc.contributor.authorDonaire Gonzalez, David
dc.contributor.authorGrazuleviciene, Regina
dc.contributor.authorHaug, Line S.
dc.contributor.authorSakhi, Amrit Kaur
dc.contributor.authorLeventakou, Vasiliki
dc.contributor.authorMcEachan, Rosemary
dc.contributor.authorNieuwenhuijsen, Mark J.
dc.contributor.authorPetraviciene, Inga
dc.contributor.authorRobinson, Oliver
dc.contributor.authorRoumeliotaki, Theano
dc.contributor.authorSunyer, Jordi
dc.contributor.authorTamayo-Uria, Ibon
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorUrquiza, José
dc.contributor.authorValentín, Antònia
dc.contributor.authorSlama, Rémy
dc.contributor.authorVrijheid, Martine
dc.contributor.authorSiroux, Valérie
dc.date.accessioned2020-04-24T09:48:54Z
dc.date.available2020-04-24T09:48:54Z
dc.date.issued2019-02-06
dc.description.abstractBackground: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children. Methods: In this analysis, we used data from 1033 mother–child pairs from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing longitudinal birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK of children born between 2003 and 2009) for whom a valid spirometry test was recorded for the child. 85 prenatal and 125 postnatal exposures relating to outdoor, indoor, chemical, and lifestyle factors were assessed, and lung function was measured by spirometry in children at age 6–12 years. Two agnostic linear regression methods, a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering exposures independently, were applied to test the association with forced expiratory volume in 1 s percent predicted values (FEV1%). We tested for two-way interaction between exposures and corrected for confounding by co-exposures. Findings: In the 1033 children (median age 8·1 years, IQR 6·5–9·0), mean FEV1% was 98·8% (SD 13·2). In the ExWAS, prenatal perfluorononanoate (p=0·034) and perfluorooctanoate (p=0·030) exposures were associated with lower FEV1%, and inverse distance to nearest road during pregnancy (p=0·030) was associated with higher FEV1%. Nine postnatal exposures were associated with lower FEV1%: copper (p=0·041), ethyl-paraben (p=0·029), five phthalate metabolites (mono-2-ethyl 5-carboxypentyl phthalate [p=0·016], mono-2-ethyl-5-hydroxyhexyl phthalate [p=0·023], mono-2-ethyl-5-oxohexyl phthalate [p=0·0085], mono-4-methyl-7-oxooctyl phthalate [p=0·040], and the sum of di-ethylhexyl phthalate metabolites [p=0·014]), house crowding (p=0·015), and facility density around schools (p=0·027). However, no exposure passed the significance threshold when corrected for multiple testing in ExWAS, and none was selected with the DSA algorithm, including when testing for exposure interactions. Interpretation: Our systematic exposome approach identified several environmental exposures, mainly chemicals, that might be associated with lung function. Reducing exposure to these ubiquitous chemicals could help to prevent the development of chronic respiratory disease.ca_ES
dc.description.sponsorshipEuropean Community's Seventh Framework Programme (HELIX project).ca_ES
dc.identifier.doihttps://doi.org/10.1016/S2542-5196(19)30010-5
dc.identifier.idgrec028396
dc.identifier.issn2542-5196
dc.identifier.urihttp://hdl.handle.net/10459.1/68496
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/S2542-5196(19)30010-5ca_ES
dc.relation.ispartofThe Lancet Planetary Health, 2019, vol. 3, núm. 2, p. e81-e92ca_ES
dc.rightscc-by-nc-nd (c) Agier, Lydiane et al., 2019ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleEarly-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohortca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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