Resilience effects of SGK1 and TAP1 DNA markers during PRRSV outbreaks in reproductive sows

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dc.contributor.authorLaplana Lafaja, Marina
dc.contributor.authorEstany Illa, Joan
dc.contributor.authorFraile Sauce, Lorenzo José
dc.contributor.authorPena i Subirà, Ramona Natacha
dc.date.accessioned2020-05-25T08:52:33Z
dc.date.available2020-05-25T08:52:33Z
dc.date.issued2020-05-22
dc.date.updated2020-05-25T08:52:33Z
dc.description.abstractThe porcine reproductive and respiratory syndrome virus (PRRSV) is a major infectious stressor that causes serious health problems and productivity drops. Based on previous genome-wide analyses, we selected SGK1 and TAP1 as candidate genes for resilience, and genotyped three mutations, including a 3′UTR variant SGK1_rs338508371 and two synonymous variants TAP1_rs1109026889 and TAP1_rs80928141 in 305 Landrace × Large White sows. All polymorphisms affected the reproductive performance in the outbreak, but not during the endemic phase, thereby indicating a potential use of these markers for resilience. Moreover, some genotypes were associated with a stable performance across PRRSV phases. Thus, in the outbreak, the SGK1_rs338508371 AA sows had less piglets born alive (p < 0.0001) and more stillborns (p < 0.05) while other sows were able to keep their productivity. During the outbreak, TAP1_rs80928141 GG sows had less piglets born alive (p < 0.05) and both TAP1 polymorphisms influenced the number of mummies in an additive manner (p < 0.05). Remarkably, TAP1_rs80928141 AA sows had around one mummy more than GG sows (p < 0.01). Resilience to PRRSV could be improved by including the SGK1 and TAP1 markers in crossbreeding and/or selection schemes, as they contribute to maintaining a stable number of piglets born alive and lost, particularly mummies, despite the outbreak.
dc.description.sponsorshipThis research and the APC were partially funded by FEDER projects COMRDI16-1-0035-03 and RTI2018-097700-B-I00 from the Spanish Ministry of Science, Innovation, and Universities. M.L. received a postdoctoral grant from UdL-Impuls programme.
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/ani10050902
dc.identifier.idgrec029992
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10459.1/68832
dc.language.isoeng
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097700-B-I00/ES/RELACION ENTRE MARCADORES MOLECULARES PARA RESILIENCIA A INFECCIONES Y LOS CARACTERES DE PRODUCCION Y CALIDAD DE CARNE EN CERDOS/
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/ani10050902
dc.relation.ispartofAnimals, 2020, vol. 10, num. 5, p. 902
dc.rightscc-by (c) Laplana Lafaja et al., 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPRRSV
dc.subjectSow
dc.subjectPigs
dc.subjectResilience
dc.subjectDNA markers
dc.subjectReproductive traits
dc.subjectMummies
dc.titleResilience effects of SGK1 and TAP1 DNA markers during PRRSV outbreaks in reproductive sows
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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