African swine fever virus infection in Classical swine fever subclinically infected wild boars
dc.contributor.author | Cabezón Ponsoda, Óscar | |
dc.contributor.author | Muñoz González, Sara | |
dc.contributor.author | Colom-Cadena, Andreu | |
dc.contributor.author | Rosell, Rosa | |
dc.contributor.author | Lavín González, Santiago | |
dc.contributor.author | Marco, Ignasi | |
dc.contributor.author | Fraile Sauce, Lorenzo José | |
dc.contributor.author | Martínez de la Riva, Paloma | |
dc.contributor.author | Rodríguez, Fernando | |
dc.contributor.author | Domínguez, Javier | |
dc.contributor.author | Ganges, Llilianne | |
dc.date.accessioned | 2017-10-17T08:47:18Z | |
dc.date.available | 2017-10-17T08:47:18Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. These animals also showed a type I interferon blockade in the absence of clinical signs. In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV). The wild boars were divided in two groups and were infected with ASFV. Group A comprised boars who were CSFV PI in a subclinical form and Group B comprised pestivirus-free wild boars. Some relevant parameters related to CSFV replication and the immune response of CSFV PI animals were studied. Additionally, serum soluble factors such as IFN-α, TNF-α, IL-6, IL-10, IFN-γ and sCD163 were analysed before and after ASFV infection to assess their role in disease progression. | ca_ES |
dc.description.sponsorship | This research was supported by grants AGL2013–48998 and AGL2015–66907 from the Spanish government. S.M and A.C had | ca_ES |
dc.identifier.doi | https://doi.org/10.1186/s12917-017-1150-0 | |
dc.identifier.idgrec | 025865 | |
dc.identifier.issn | 1746-6148 | |
dc.identifier.uri | http://hdl.handle.net/10459.1/60302 | |
dc.language.iso | eng | ca_ES |
dc.publisher | BioMed Central | ca_ES |
dc.relation | MINECO/PN2013-2016/AGL2013-48998 | |
dc.relation | MINECO/PN2013-2016/AGL2015-66907 | |
dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.1186/s12917-017-1150-0 | ca_ES |
dc.relation.ispartof | BMC Veterinary Research, 2017, vol. 13, p. 227 | ca_ES |
dc.rights | cc-by (c) Cabezón et al., 2017 | ca_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | CSFV | ca_ES |
dc.subject | CSF postnatal persistent infection | ca_ES |
dc.subject | Subclinical CSF | ca_ES |
dc.subject | ASFV | ca_ES |
dc.title | African swine fever virus infection in Classical swine fever subclinically infected wild boars | ca_ES |
dc.type | article | ca_ES |
dc.type.version | publishedVersion | ca_ES |