Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

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dc.contributor.authorCirer-Sastre, Rafel
dc.contributor.authorLegaz Arrese, Alejandro
dc.contributor.authorCorbi Soler, Francesc
dc.contributor.authorGeorge, Keith
dc.contributor.authorNie, Jinlei
dc.contributor.authorCarranza García, Luis E.
dc.contributor.authorReverter Masià, Joaquín
dc.date.accessioned2019-03-19T09:42:23Z
dc.date.available2019-03-19T09:42:23Z
dc.date.issued2019
dc.description.abstractThe authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay. Method: Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed. Results: From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3, P < .001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9, P = .003). Conclusion: Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.ca_ES
dc.identifier.doihttps://doi.org/10.1123/pes.2018-0058
dc.identifier.idgrec030271
dc.identifier.issn0899-8493
dc.identifier.urihttp://hdl.handle.net/10459.1/65968
dc.language.isoengca_ES
dc.publisherHuman Kineticsca_ES
dc.relation.isformatofVersió postprint del document publicat a https://doi.org/10.1123/pes.2018-0058ca_ES
dc.relation.ispartofPediatric Exercise Science, 2019, vol.31, núm. 1, p. 28-36ca_ES
dc.rights(c) Human Kinetics, 2019ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.subjectSport medicineca_ES
dc.subjectcTnTca_ES
dc.subjectcTnIca_ES
dc.subjectNT-proBNPca_ES
dc.titleCardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysisca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionca_ES
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