Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study
dc.contributor.author | Gutiérrez Carrasquilla, Liliana | |
dc.contributor.author | López Cano, Carolina | |
dc.contributor.author | Sánchez Peña, Enric | |
dc.contributor.author | Barbé Illa, Ferran | |
dc.contributor.author | Dalmases, Mireia | |
dc.contributor.author | Hernández García, Marta | |
dc.contributor.author | Campos, Angela | |
dc.contributor.author | Gaeta, Anna Michela | |
dc.contributor.author | Carmona, Paola | |
dc.contributor.author | Hernández, Cristina | |
dc.contributor.author | Simó, Rafael | |
dc.contributor.author | Lecube Torelló, Albert | |
dc.date.accessioned | 2020-10-01T10:16:22Z | |
dc.date.available | 2020-10-01T10:16:22Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Type 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 diabetes and obstructive sleep apnea (OSA) to explore this. At home, sleep breathing parameters were assessed at baseline and after a 4-month period in which antidiabetic therapy was intensified. Patients who decreased their body mass index ≥2kg/m2 were excluded. Those with an HbA1c reduction ≥0.5% were considered good responders (n = 24). After the follow-up, good responders exhibited an improvement in the apnea–hypopnea index (AHI: 26-1 (95% IC: 8.6–95.0) vs. 20.0 (4.0–62.4) events/hour, p = 0.002) and in time with oxygen saturation below 90% (CT90: 13.3 (0.4–69.0) vs. 8.1 (0.4–71.2) %, p = 0.002). No changes were observed in the group of non–responders (p = 0.722 and p = 0.138, respectively). The percentage of moderate and severe OSA decreased among good responders (p = 0.040). In the wider population, the change in HbA1c correlated positively to decreases in AHI (r = 0.358, p = 0.035) and negatively to increases in the minimum arterial oxygen saturation (r = −0.386, p = 0.039). Stepwise multivariate regression analysis showed that baseline AHI and the absolute change in HbA1c independently predicted decreased AHI (R2 = 0.496). The improvement of glycemic control exerts beneficial effects on sleep breathing parameters in type 2 diabetes, which cannot be attributed merely to weight loss. | ca_ES |
dc.description.sponsorship | This study was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria, PI 12/00803, PI 15/00260 and PI18/00964), the European Union, the European Regional Development Fund (Fondo Europeo de Desarrollo Regional, FEDER, “Una manera de hacer Europa”), Fundación Sociedad Española de Endocrinología y Nutrición (SEEN), and Menarini Spain S.A. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and CIBER de Enfermedades Respiratorias (CIBERES) are initiatives of the Instituto Carlos III. | ca_ES |
dc.identifier.doi | https://doi.org/10.3390/jcm9041022 | |
dc.identifier.idgrec | 029936 | |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | http://hdl.handle.net/10459.1/69586 | |
dc.language.iso | eng | ca_ES |
dc.publisher | MDPI | ca_ES |
dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.3390/jcm9041022 | ca_ES |
dc.relation.ispartof | Journal of Clinical Medicine, 2020, vol. 9, núm. 4, p. 1022 | ca_ES |
dc.rights | cc-by (c) Gutiérrez Carrasquilla, Liliana et al., 2020 | ca_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Diabetes | ca_ES |
dc.subject | Apnea | ca_ES |
dc.subject | Hypoxia | ca_ES |
dc.subject | Glycated hemoglobin | ca_ES |
dc.title | Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study | ca_ES |
dc.type | info:eu-repo/semantics/article | ca_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |