Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography
| dc.contributor.author | Sivo, Alessandra | |
| dc.contributor.author | Kim, Tae Keun | |
| dc.contributor.author | Ruta, Vincenzo | |
| dc.contributor.author | Luisi, Renzo | |
| dc.contributor.author | Osorio-Tejada, José | |
| dc.contributor.author | Escribà i Gelonch, Marc | |
| dc.contributor.author | Hessel, Volker | |
| dc.contributor.author | Sponchioni, Mattia | |
| dc.contributor.author | Vile, Gianvito | |
| dc.date.accessioned | 2022-11-16T12:58:03Z | |
| dc.date.available | 2022-11-16T12:58:03Z | |
| dc.date.issued | 2022-09 | |
| dc.description.abstract | We report an improved approach for the integration of flow synthesis and continuous chromatography, for applications in the end-to-end preparation of pharmaceutically-relevant small molecules. It involves the combination of sequential microreactors and twin-column counter-current chromatography based on the often-used C18 columns. The column loading method ensures that the product breaking through a fully loaded first column is loaded onto the second one, avoiding waste of precious material and technological complexity associated with the use of four-to-six columns typical of simulated moving bed chromatography. The system was applied to synthesize biphenyl via Suzuki–Miyaura reaction, and was also demonstrated for other structurally-different compounds. Compared to the discontinuous and other traditional approaches, our method leads to higher isolated yields (ca. +60%), higher productivity (ca. +30%), and reduced solvent consumption (ca. −80%). A circularity and life-cycle analysis was also conducted to demonstrate the environmental benefits of the flow process. | ca_ES |
| dc.description.sponsorship | Funding from the European Commission (GV, grant agreement 101031710), Bracco Imaging (AS, VR, and GV), Fondazione Bracco (GV), and YMC Japan (TKK and MS) is gratefully acknowledged. | ca_ES |
| dc.identifier.doi | https://doi.org/10.1039/D2RE00242F | |
| dc.identifier.issn | 2058-9883 | |
| dc.identifier.uri | http://hdl.handle.net/10459.1/84236 | |
| dc.language.iso | eng | ca_ES |
| dc.publisher | Royal Society of Chemistry | ca_ES |
| dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.1039/D2RE00242F | ca_ES |
| dc.relation.ispartof | Reaction Chemistry & Engineering, 2022 | ca_ES |
| dc.rights | cc-by-nc (c) Sivo, Alessandra et al., 2022 | ca_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject | Flow synthesis | ca_ES |
| dc.subject | Small molecules | ca_ES |
| dc.subject | Chromatography | ca_ES |
| dc.title | Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography | ca_ES |
| dc.type | info:eu-repo/semantics/article | ca_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |