Dynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during development

Simple item page
dc.contributor.authorDávila, José Carlos
dc.contributor.authorOlmos, Luis
dc.contributor.authorLegaz, Isabel
dc.contributor.authorMedina Hernández, Loreta Mª
dc.contributor.authorGuirado, Salvador
dc.contributor.authorReal, M. Ángeles
dc.date.accessioned2017-01-20T09:20:26Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2008
dc.description.abstractCalbindin cells represent a major interneuron subtype of the cortical/pallial regions, such as the basolateral amygdala, which are often analyzed in studies of tangential migration of interneurons from the subpallial ganglionic eminences to the pallium/cortex. However, previous evidence suggests that during development the calbindin cells may include more than one of the interneuron subtypes found in the adult pallium/cortex. Furthermore, in the adult basolateral amygdala, calbindin cells include a subpopulation of non-GABAergic (non-interneuron) cells. To better characterize these cells throughout development, in the present study we investigated the colocalization of calbindin, parvalbumin and GABA in cells of the mouse basolateral amygdala during late embryonic (E16.5) and several postnatal ages from birth until 4 weeks after birth (P0, P10 and P28). Our results indicate that CB, PV and GABA show a dynamic pattern of colocalization in cells of the mouse basolateral amygdalar nucleus throughout development. From E16.5 through P28, the majority of CB+ neurons and virtually all PV+ neurons are GABAergic. However, after P10, the percentage of GABAergic CB+ cells decline from 96% to 70%. Furthermore, while only 9% of CB+ neurons are PV+ at P10, this percentage raises to 42% at P28. At all postnatal ages studied, the majority of the PV+ cells are CB+, suggesting that PV+ interneurons develop postnatally mainly as a subpopulation within the CB+ cells of the basolateral amygdalar nucleus. These results are important for interpreting data from interneuron migration.ca_ES
dc.description.sponsorshipThis work was supported by Spanish BFU2006-14804-C02- 01/BFI and BFU2006-14804-C02-02/BFI.ca_ES
dc.identifier.doihttps://doi.org/10.1016/j.jchemneu.2007.06.003
dc.identifier.idgrec011380
dc.identifier.issn0891-0618
dc.identifier.urihttp://hdl.handle.net/10459.1/59049
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationinfo:eu-repo/grantAgreement/MEC//BFU2006-14804-C02-01/ES/COMPARTIMENTACION HISTOGENETICA Y MADURACION FUNCIONAL DE LA AMIGDALA/
dc.relationinfo:eu-repo/grantAgreement/MEC//BFU2006-14804-C02-02/ES/COMPARTIMENTACION HISTOGENETICA Y MADURACION FUNCIONAL DE LA AMIGDALA/
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.jchemneu.2007.06.003ca_ES
dc.relation.ispartofJournal of Chemical Neuroanatomy, 2008, vol. 35, núm. 1, p. 67–76ca_ES
dc.rights(c) Elsevier B.V., 2007ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.subjectInterneuronsca_ES
dc.subjectCalcium binding proteinsca_ES
dc.subjectPallial amygdalaca_ES
dc.subjectNeuroanatomyca_ES
dc.subjectImmunohistochemistryca_ES
dc.titleDynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during developmentca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Articles publicats (Medicina Experimental)
Articles publicats (IRBLleida)
Publicacions de projectes de recerca del Plan Nacional