Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study

dc.contributor.authorFernández Castillejo, Sara
dc.contributor.authorPedret, Anna
dc.contributor.authorCatalán Santos, Úrsula
dc.contributor.authorValls, Rosa Maria
dc.contributor.authorFarràs, Marta
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorCastañer, Olga
dc.contributor.authorMacià i Puig, Ma Alba
dc.contributor.authorFitó, Montserrat
dc.contributor.authorMotilva Casado, Mª José
dc.contributor.authorCovas Planells, María Isabel
dc.contributor.authorGiera, Martin
dc.contributor.authorRemaley, Alan T.
dc.contributor.authorSolà, Rosa
dc.date.accessioned2021-11-17T09:19:31Z
dc.date.available2021-11-17T09:19:31Z
dc.date.issued2021
dc.description.abstractScope The lipidomic analysis of high-density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function. Methods and results A randomized, controlled, double-blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriched with its own phenolic compounds (FVOO), or VOO enriched with additional phenolic compounds from thyme (FVOOT) for 3 weeks. HDL lipidomic analyses are performed using the Lipidyzer platform. VOO and FVOO intake increase monounsaturated-fatty acids (FAs) and decrease saturated and polyunsaturated FAs in triacylglyceride (TAG) species, among others species. In contrast, FVOOT intake does not induce these FAs changes. The decrease in TAG52:3(FA16:0) after VOO intake and the decrease in TAG52:5(FA18:2) after FVOO intake are inversely associated with changes in HDL resistance to oxidation. After FVOO intake, the decrease in TAG54:6(FA18:2) in HDL is inversely associated with changes in HDL cholesterol efflux capacity. Conclusion VOO and FVOO consumption has an impact on the HDL lipidome, in particular TAG species. Although TAGs are minor components of HDL mass, the observed changes in TAG modulated HDL functionality towards a cardioprotective mode. The assessment of the HDL lipidome is a valuable approach to identify and characterize new biomarkers of HDL function.ca_ES
dc.description.sponsorshipThe VOHF project (AGL2009-13517-457 C03-01) and the AppleCORProject (AGL2016-76943-C2) were made possible with the support of theMinisterio de Economía, Indústria y Competitividad, theAgencia Estatal de In-vestigación, and the European Regional Development Fund. U.C. has aPlaEstratègic de Recerca i Innovació en Salut(PERIS) postdoctoral grant (no.SLT002/16/00239; Catalunya, Spain) from theGeneralitat de Catalunya.A.P. has a Torres Quevedo postdoctoral grant with theSubprograma Es-tatal de Incorporación,Plan Estatal de Investigación Científica Técnica y deInnovación. M.F. has a Sara Borrell postdoctoral contract (CD17/00233 toM.F.-St.Pau). O.C. has a JR17/00022 contract fromInstituto de Salud CarlosIII.CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)is a project ofInstituto de Salud Carlos III(Madrid, Spain). The NFOC-Salutgroup is a consolidated research group of theGeneralitat de Catalunya,Spain (reference no. 2017 SGR 522)ca_ES
dc.identifier.doihttps://doi.org/10.1002/mnfr.202001192
dc.identifier.idgrec031482
dc.identifier.issn1613-4125
dc.identifier.urihttp://hdl.handle.net/10459.1/72341
dc.language.isoengca_ES
dc.publisherWiley-VCH GmbHca_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-01/ES/Aceite De Oliva Virgen Y Funcionalidad De La Hdl: Un Modelo De Preparacion Especializada De Un Alimento Funcional/ca_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO//AGL2016-76943-C2/ES/ca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/mnfr.202001192ca_ES
dc.relation.ispartofMolecular Nutrition & Food Research, 2021, vol.65, núm. 9, 2001192ca_ES
dc.rightscc-by (c) Fernández-Castillejo et al., 2021ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCholesterol effluxca_ES
dc.subjectHDL functionalityca_ES
dc.subjectLipidomicsca_ES
dc.subjectResistanceto oxidationca_ES
dc.titleVirgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Studyca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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