Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study
dc.contributor.author | Fernández Castillejo, Sara | |
dc.contributor.author | Pedret, Anna | |
dc.contributor.author | Catalán Santos, Úrsula | |
dc.contributor.author | Valls, Rosa Maria | |
dc.contributor.author | Farràs, Marta | |
dc.contributor.author | Rubió Piqué, Laura | |
dc.contributor.author | Castañer, Olga | |
dc.contributor.author | Macià i Puig, Ma Alba | |
dc.contributor.author | Fitó, Montserrat | |
dc.contributor.author | Motilva Casado, Mª José | |
dc.contributor.author | Covas Planells, María Isabel | |
dc.contributor.author | Giera, Martin | |
dc.contributor.author | Remaley, Alan T. | |
dc.contributor.author | Solà, Rosa | |
dc.date.accessioned | 2021-11-17T09:19:31Z | |
dc.date.available | 2021-11-17T09:19:31Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Scope The lipidomic analysis of high-density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function. Methods and results A randomized, controlled, double-blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriched with its own phenolic compounds (FVOO), or VOO enriched with additional phenolic compounds from thyme (FVOOT) for 3 weeks. HDL lipidomic analyses are performed using the Lipidyzer platform. VOO and FVOO intake increase monounsaturated-fatty acids (FAs) and decrease saturated and polyunsaturated FAs in triacylglyceride (TAG) species, among others species. In contrast, FVOOT intake does not induce these FAs changes. The decrease in TAG52:3(FA16:0) after VOO intake and the decrease in TAG52:5(FA18:2) after FVOO intake are inversely associated with changes in HDL resistance to oxidation. After FVOO intake, the decrease in TAG54:6(FA18:2) in HDL is inversely associated with changes in HDL cholesterol efflux capacity. Conclusion VOO and FVOO consumption has an impact on the HDL lipidome, in particular TAG species. Although TAGs are minor components of HDL mass, the observed changes in TAG modulated HDL functionality towards a cardioprotective mode. The assessment of the HDL lipidome is a valuable approach to identify and characterize new biomarkers of HDL function. | ca_ES |
dc.description.sponsorship | The VOHF project (AGL2009-13517-457 C03-01) and the AppleCORProject (AGL2016-76943-C2) were made possible with the support of theMinisterio de Economía, Indústria y Competitividad, theAgencia Estatal de In-vestigación, and the European Regional Development Fund. U.C. has aPlaEstratègic de Recerca i Innovació en Salut(PERIS) postdoctoral grant (no.SLT002/16/00239; Catalunya, Spain) from theGeneralitat de Catalunya.A.P. has a Torres Quevedo postdoctoral grant with theSubprograma Es-tatal de Incorporación,Plan Estatal de Investigación Científica Técnica y deInnovación. M.F. has a Sara Borrell postdoctoral contract (CD17/00233 toM.F.-St.Pau). O.C. has a JR17/00022 contract fromInstituto de Salud CarlosIII.CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)is a project ofInstituto de Salud Carlos III(Madrid, Spain). The NFOC-Salutgroup is a consolidated research group of theGeneralitat de Catalunya,Spain (reference no. 2017 SGR 522) | ca_ES |
dc.identifier.doi | https://doi.org/10.1002/mnfr.202001192 | |
dc.identifier.idgrec | 031482 | |
dc.identifier.issn | 1613-4125 | |
dc.identifier.uri | http://hdl.handle.net/10459.1/72341 | |
dc.language.iso | eng | ca_ES |
dc.publisher | Wiley-VCH GmbH | ca_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN//AGL2009-13517-C03-01/ES/Aceite De Oliva Virgen Y Funcionalidad De La Hdl: Un Modelo De Preparacion Especializada De Un Alimento Funcional/ | ca_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO//AGL2016-76943-C2/ES/ | ca_ES |
dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.1002/mnfr.202001192 | ca_ES |
dc.relation.ispartof | Molecular Nutrition & Food Research, 2021, vol.65, núm. 9, 2001192 | ca_ES |
dc.rights | cc-by (c) Fernández-Castillejo et al., 2021 | ca_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cholesterol efflux | ca_ES |
dc.subject | HDL functionality | ca_ES |
dc.subject | Lipidomics | ca_ES |
dc.subject | Resistanceto oxidation | ca_ES |
dc.title | Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study | ca_ES |
dc.type | info:eu-repo/semantics/article | ca_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |