Neuropsychological profile in bipolar disorder: a preliminary study of monotherapy lithium-treated euthymic bipolar patients evaluated at a 2-year interval
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Date
2008
Authors
Mur, Maria
Portella, Maria J.
Martínez-Aran, A.
Pifarré Paredero, Josep
Vieta i Pascual, Eduard, 1963-
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Abstract
Objective: To investigate the cognitive impairment of a sample of
euthymic bipolar patients treated with lithium monotherapy at baseline
in a 2-year longitudinal study.
Method: Fifteen DSM-IV-TR bipolar out-patients and 15
healthy-matched controls were cognitively assessed twice over a 2-year
follow-up. All patients underwent lithium monotherapy on the first
evaluation, and they were euthymic in both evaluations. Cognitive
assessment was performed by means of a neuropsychological test
battery tapping into the main cognitive domains (executive function,
attention, processing speed, verbal memory and visual memory).
Results: Repeated measures multivariate analysis of variance showed
that the bipolar disorder group was cognitively impaired in the
executive domain, attention and processing speed, and such deficits
were maintained over time.
Conclusion: Our results showed that executive dysfunction is the main
long-term neuropsychological deficit of bipolar disorder. Also, the
persistence of these deficits did not seem to be influenced by any clinical
or pharmacological variables.
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Acta Psychiatrica Scandinavica, 2008, vol. 118, núm. 5, p. 373-381