Toll Like Receptor 2 promoter -196 to -174 deletion affects CD4 levels along HIV infection progression

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dc.contributor.authorLaplana Lafaja, Marina
dc.contributor.authorBravo, M. J.
dc.contributor.authorFernández-Fuertes, M.
dc.contributor.authorRuiz-García, C.
dc.contributor.authorAlarcón-Martin, Emilio
dc.contributor.authorColmenero, J. D.
dc.contributor.authorCaruz, Antonio
dc.contributor.authorFibla Palazón, Joan
dc.contributor.authorReal, Luis M.
dc.contributor.authorRoyo Sánchez-Palencia, José Luis
dc.date.accessioned2020-06-29T09:35:36Z
dc.date.available2021-06-09T22:32:43Z
dc.date.issued2020-06-09
dc.date.updated2020-06-29T09:35:36Z
dc.description.abstractTLR2 plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter Insertion/Deletion polymorphism with contradictory data about its role in HIV-1 infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4+<200cells/μL outcome for Deletion allele carriers (Cox regression analysis: Hazard Ratio=2.4; 95%CI:1.4-4, P=0.001). When naïve patients with CD4+<200cells/μL start antiretroviral treatment, rs111200466-Deletion carriers showed a trend towards a slower, recovery rate (time required to reach CD4+>350cells/μL, Cox P=0.36). Our data suggests rs111200466 as a prognosis factor for HIV-1 disease progression.
dc.description.sponsorshipThis work was supported by grant SAF2016-80125-R (Ministerio de Economía, Industria y Competitividad, Spain) to AC., grant PI-0001-2017 (Consejería de salud, Spain) to L.M. Real and by grant SAS111229 supported by the Junta de Andalucía to M.J. Bravo.
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jiaa327
dc.identifier.idgrec030102
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/10459.1/69138
dc.language.isoeng
dc.publisherInfectious Diseases Society of America
dc.publisherOxford University Press
dc.relationinfo:eu-repo/grantAgreement/MINECO//SAF2016-80125-R/ES/
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1093/infdis/jiaa327
dc.relation.ispartofThe Journal of Infectious Diseases, 2020, vol. 222, núm. 12, p. 2007–2011
dc.rights(c) Laplana Lafaja, Marina et al., 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectPolymorphism
dc.subjectHIV infection
dc.subjectHIV progression
dc.titleToll Like Receptor 2 promoter -196 to -174 deletion affects CD4 levels along HIV infection progression
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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