Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

Simple item page
dc.contributor.authorPradas Barriga, Irene
dc.contributor.authorJové Font, Mariona
dc.contributor.authorHuynh, Karina
dc.contributor.authorPuig Farré, Josep
dc.contributor.authorInglés, Marta
dc.contributor.authorBorrás, Consuelo
dc.contributor.authorViña Ribes, José
dc.contributor.authorMeikle, Peter J.
dc.contributor.authorPamplona Gras, Reinald
dc.date.accessioned2019-03-11T08:45:02Z
dc.date.available2019-03-11T08:45:02Z
dc.date.issued2019
dc.description.abstractA lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state. This profile comprises higher level of alkyl forms derived from phosphatidylcholine with shorter number of carbon atoms and double bonds; and decreased content in alkenyl forms from phosphatidylethanolamine with longer chain length and higher double bonds. This compositional pattern suggests that ether lipids from centenarians are more resistant to lipid peroxidation, and that ether lipid signature expresses an optimized feature associated with exceptional human longevity. These results are in keeping with the free radical theory of aging.ca_ES
dc.description.sponsorshipWe acknowledge funding from the Spanish Ministry of Education and Science (ref. SAF2013–44663-R), and from the ‘Red Tematica de Investigación Cooperativa en Envejecimiento y Fragilidad’ (RETICEF) (ref. ISCIII2012-RED-43-029) to J.V.; and from the Spanish Ministry of Economy and Competitiveness/Institute of Health Carlos III (ref. PI14/00328), and the Autonomous Government of Catalonia, Department of Health (ref. SLT002/16/00250) and Department of Business and Knowledge (ref. 2017SGR696) to R.P. This study has been co-financed by FEDER funds from the European Union (“Una manera de hacer Europa”). I.P. was supported by a University of Lleida Predoctoral Fellowship. K.H. was supported by a Dementia Australia Research Foundation Scholarship.ca_ES
dc.identifier.doihttps://doi.org/10.1016/j.redox.2019.101127
dc.identifier.idgrec029429
dc.identifier.issn2213-2317
dc.identifier.urihttp://hdl.handle.net/10459.1/65924
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO//SAF2013-44663-R/ES/IDENTIFICACION DE BIOMARCADORES DE FRAGILIDAD Y DE ESTRATEGIAS PARA SU PREVENCION Y TRATAMIENTO. CENTENARIOS COMO UN MODELO DE ENVEJECIMIENTOSALUDABLE/
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.redox.2019.101127ca_ES
dc.relation.ispartofRedox Biology, 2019, vol. 21, núm. 101127, p. 1-9ca_ES
dc.rightscc- by-nc-nd (c) Elsevier, 2019ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlkenyl phospholipidsca_ES
dc.subjectAlkyl phospholipidsca_ES
dc.subjectCentenariansca_ES
dc.subjectFatty acid unsaturationca_ES
dc.titleExceptional human longevity is associated with a specific plasma phenotype of ether lipidsca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
redoxbiology_a2019v21n101127p1.pdf
Size:
2.28 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Articles publicats (Medicina Experimental)
Articles publicats (IRBLleida)
Publicacions de projectes de recerca del Plan Nacional