Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
| dc.contributor.author | Altet, Neus | |
| dc.contributor.author | Latorre, Irene | |
| dc.contributor.author | Jiménez-Fuentes, María Ángeles | |
| dc.contributor.author | Soriano Arandes, Antoni | |
| dc.contributor.author | Villar-Hernández, Raquel | |
| dc.contributor.author | Milà, Celia | |
| dc.contributor.author | Rodríguez Fernández, Pablo | |
| dc.contributor.author | Muriel Moreno, Beatriz | |
| dc.contributor.author | Comella-Del-Barrio, Patricia | |
| dc.contributor.author | Godoy i García, Pere | |
| dc.contributor.author | Millet, Joan Pau | |
| dc.contributor.author | de Souza-Galvão, Maria Luiza | |
| dc.contributor.author | Jiménez-Ruiz, Carlos A. | |
| dc.contributor.author | Domínguez, Jose | |
| dc.date.accessioned | 2022-05-05T10:15:33Z | |
| dc.date.available | 2022-05-05T10:15:33Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9-12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79-11.94)] and active TB [aOR (95% CI): 3.40 (1.45-7.98)]. Moreover, IGRAs' sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response. | ca_ES |
| dc.description.sponsorship | This research was supported by: (i) a grant from the Instituto de Salud Carlos III (PI13/01546, PI16/01912, and PI18/00411), integrated in the Plan Nacional I+D+I and co-funded by the ISCIII Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER) and CERCA Programme/Generalitat de Catalunya; and (ii) a grant from the Sociedad Española de Neumología y Cirugía Torácica (SEPAR; Barcelona, Spain) (Smoking Integrated Research Programme Call) | ca_ES |
| dc.identifier.doi | https://doi.org/10.3390/jcm11072000 | |
| dc.identifier.issn | 2077-0383 | |
| dc.identifier.uri | http://hdl.handle.net/10459.1/83222 | |
| dc.language.iso | eng | ca_ES |
| dc.publisher | MDPI | ca_ES |
| dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm11072000 | ca_ES |
| dc.relation.ispartof | Journal of Clinical Medicine, 2022, vol. 11, núm. 7 | ca_ES |
| dc.rights | cc-by (c) Authors, 2022 | ca_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Mycobacterium tuberculosis | ca_ES |
| dc.subject | Child | ca_ES |
| dc.subject | Cigarette smoking | ca_ES |
| dc.subject | Immunology | ca_ES |
| dc.subject | Passive smoking | ca_ES |
| dc.title | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children | ca_ES |
| dc.type | info:eu-repo/semantics/article | ca_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |