In vivo biotransformation of (poly)phenols and anthocyanins of red-fleshed apple and identification of intake biomarkers
| dc.contributor.author | Yuste, Silvia | |
| dc.contributor.author | Ludwig, Iziar A. | |
| dc.contributor.author | Rubió Piqué, Laura | |
| dc.contributor.author | Romero Fabregat, Mª Paz | |
| dc.contributor.author | Pedret, Anna | |
| dc.contributor.author | Valls, Rosa M. | |
| dc.contributor.author | Solà, Rosa | |
| dc.contributor.author | Motilva Casado, Mª José | |
| dc.contributor.author | Macià i Puig, Ma Alba | |
| dc.date.accessioned | 2019-02-12T10:17:38Z | |
| dc.date.available | 2020-04-01T22:11:06Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | The aim of this study was to investigate comprehensively the metabolic pathways and human bioavailability of anthocyanins and other phenolic compounds in apple matrix, and to elucidate potential intake biomarkers. After the acute intake of a red-fleshed apple snack, plasma and urine were collected and analyzed by UPLC-MS/MS. A total of 37 phase-II and microbial phenolic metabolites were detected in plasma and urine. Among these, phloretin glucuronide, cyanidin-3-O-galactoside (plasma and urine) and peonidin-3-O galactoside (urine) were the only metabolites detected in all the volunteers and not detected at basal conditions. The maximum urine excretion was detected at 2-4 h, and the main increase in plasma of phloretin glucuronide and cyanidin-3-O-galactoside was observed at 2h post-intake (61.0 6.82 and 10.3 1.50 nM, respectively). These metabolites could be selected as the best intake biomarkers of red-fleshed apple that might be useful in human intervention studies when studying the bioactivity of red-fleshed apple. | ca_ES |
| dc.description.sponsorship | This study was supported by the Spanish Ministry of Industry, Economy and Competitiveness through the AGL2016-76943-C2-1-R and AGL2016-76943-C2- 2-R projects (co-funded by the European Social Fund, European Union); I.A.L. enjoys a post-doctoral contract (2017PMF-POST2-19) from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV). S.Y. was supported by a grant from the University of Lleida. In addition, the authors are grateful to NUFRI SAT (Mollerussa, Lleida, Catalonia, Spain) for providing the red-fleshed apples. A.P. has Torres Quevedo contract (Subprograma Estatal de Incorporación, Plan Estatal de Investigación Científica y Técnica y de Innovación). NFOC-Salut group is a consolidated research group of Generalitat de Catalunya, Spain (2017 SGR522). | ca_ES |
| dc.identifier.doi | https://doi.org/10.1016/j.jff.2019.02.013 | |
| dc.identifier.idgrec | 028288 | |
| dc.identifier.issn | 1756-4646 | |
| dc.identifier.uri | http://hdl.handle.net/10459.1/65728 | |
| dc.language.iso | eng | ca_ES |
| dc.publisher | Elsevier | ca_ES |
| dc.relation | MINECO/PN2013-2016/AGL2016-76943-C2-1-R | ca_ES |
| dc.relation | MINECO/PN2013-2016/AGL2016-76943-C2-2-R | ca_ES |
| dc.relation.isformatof | Versió postprint del document publicat a https://doi.org/10.1016/j.jff.2019.02.013 | |
| dc.relation.ispartof | Journal of Functional Foods, 2019, vol. 55, p. 146-155 | ca_ES |
| dc.rights | cc-by-nc-nd (c) Elsevier, 2019 | ca_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | Anthocyanins | ca_ES |
| dc.subject | Metabolic pathways | ca_ES |
| dc.subject | Phenolic compounds | ca_ES |
| dc.subject | Red-fleshed apple | ca_ES |
| dc.subject | UPLC-MS/MS | ca_ES |
| dc.title | In vivo biotransformation of (poly)phenols and anthocyanins of red-fleshed apple and identification of intake biomarkers | ca_ES |
| dc.type | info:eu-repo/semantics/article | ca_ES |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | ca_ES |